Thrilled to share the latest review I had the incredible pleasure to write together with @amustoe.bsky.social, out today in #COSB, about probing #RNA structural ensembles, non-equilibrium intermediates and isoforms. Check it out: www.sciencedirect.com/science/arti...

📢 #Postdoc job: I am looking for a #bioinformatician to join my lab for investigating #XchromosomeInactivation and #chromatin-mediated #epigenetic mechanisms underlying #sexbias in #MultipleSclerosis. Please RT

Excited to share our PNAS paper with @jorg-vogel-lab.bsky.social and @westermannlab.bsky.social! We identify SAILR, a human-specific lncRNA that binds 14-3-3β to support macrophage viability—its loss during infection strengthens antimicrobial defense. #RNA www.pnas.org/doi/10.1073/...

🚀 We're hiring! Join the founding Digital Twin Team at the SCALE Cluster of Excellence @goetheuni.bsky.social Apply by: 31 August 2026 For more information: scale-frankfurt.org/wp-content/u... Full position description: scale-frankfurt.org/wp-content/u... Descriptions below 🧵:

♨️Hot off the press, new study from our group: 🧬🤖 DNA language model for predicting mutation risk trained on massive genomic data sets A mutation seen again and again across cancer genomes looks like a causal change. But sometimes the DNA site is simply very easy to mutate & so generates a hotspot🔥

#RNA Framework 2.9.7 is out! Several additions, important fixes and improvements. Please update! Check it out: github.com/dincarnato/R... & see the CHANGELOG (buff.ly/4gtJ67u) for the details!

GitHub - dincarnato/RNAFramework: RNA structure probing and post-transcriptional modifications mapping high-throughput data analysis

RNA structure probing and post-transcriptional modifications mapping high-throughput data analysis - dincarnato/RNAFramework

github.com

📣 POSTDOC position available in the Feschotte Lab at Cornell to work on #TRANSPOSONS! More details below. Pls send informal application or inquiry ASAP by DM or email to cf458_at_cornell.edu. Pls spread the word 🙏 #TEsky www.thefeschottelabatcornell.com

Seminar Alert: *Prof. Elena Conti* 'RNA exosome complex: Molecular Mechanisms of RNA degradation in health and disease' When: 18.06.2026, 14:00 Where: Haus 22-1 (lecture hall H22-1), Neiderad Campus (Uni KliniK), Goethe University RT🙏 @scale-cluster-ffm.bsky.social @goetheuni.bsky.social

Our lab is expanding! We are looking for a PhD candidate interested in RNA localization & targeting as part of the newly funded TRR440 smART: specific mRNA targeting. An exciting opportunity to work on RNA biology & innovative approaches in a collaborative environment. For details shorturl.at/RjyhE

Our preprint on how variant U1 snRNAs control transcriptional and splicing homeostasis of hiPSCs is now officially out in @natcomms.nature.com and accessible via this link: www.nature.com/articles/s41... This has been the culmination of our work as part of the SPP1935 program funded by @dfg.de 1/n

Akis (Argyris) Papantonis @akispapantonis.bsky.social · 11mo ago

In our latest preprinted work, Yajie and Kostas combine computational analysis with precision KO of single variant U1 snRNA genes in human iPSCs to find pronounced deregulation of both gene expression and splicing that seem to affect the cell cycle and the differentiation potency of stem cells. 1/n

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...

Temporal Transcriptomics Identifies Isoform-specific Trans-regulation by Multiple lncRNAs in Human iPSCs https://www.biorxiv.org/content/10.64898/2026.05.13.724994v1

Sounds super interesting - hope we'll see more of these (lncRNAs linked by human genetics + mouse KOs to key phenotypes)! www.nature.com/articles/s41...

An X-linked long non-coding RNA, PTCHD1-AS, and the core features of autism - Nature

PTCHD1-AS, which encodes a long non-coding RNA, is associated with the aetiology of autism spectrum disorder in humans through striatal molecular and circuit-level dysregulation.

nature.com

Excited to share our @natgenet.nature.com study showing that epigenetically rewired transposable elements control AML leukemia stem cell properties and patient outcome. Grateful to the team & collaborators. www.nature.com/articles/s41...

Transposable elements shape stemness in normal and leukemic hematopoiesis - Nature Genetics

This study identifies distinct transposable element subfamilies as genetic determinants of stemness properties in normal and leukemic stem populations with clinical implications for patients with acut...

nature.com

1/ ProPER - Our novel ligation-free proximity detection method for efficient multiplexed imaging of molecular interactions in situ. Among other things we use it to image the life cycle of RNA molecules and resolve differential kinetics of gene expression steps. New preprint: doi.org/10.64898/202...

If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/202.... They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.

Thrilled to see this work published. Thanks to helpful reviewer suggestions, there are some exciting new insights that were not in the preprint (particularly in Figure 4). www.nature.com/articles/s41...

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 3mo ago

The hidden rules behind mRNA transport. A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs. Read more: mrclmb.ac.uk/news-events/... #LMBNews @cellbiol-mrclmb.bsky.social 🧪

🚨 Excited to share a new paper in Cell! Human genetics led us to HOTSCRAMBL, a HOXA-locus lncRNA that regulates 🩸#stemcell self-renewal and HOXA9 splicing, with implications for AML. Amazing work by @lvchosen1.bsky.social with many others! www.cell.com/cell/fulltex...

Excited to see this collaborative work with @oligopain.bsky.social and @keribackus.bsky.social out as a preprint now! Took a ton of work from a great team of scientists @uwgenome.bsky.social and #UCLA The imaging coupled with proteomics open our eyes to new aspects of subcellular organization!

Keri Backus@keribackus.bsky.social · 3mo ago

Super excited to launch POCAxOMAP with @dschweppe.bsky.social and @oligopain.bsky.social and led by Eli Biletch, Conor Herlihy and Lidan Li. If you’ve ever wanted to do proximity labeling on DNA, RNA, or protein without genetic engineering, look no further. www.biorxiv.org/content/10.6...

Our new article in Trends in Genetics with Sonia Forcales discusses SST1/NBL2, a primate-specific macrosatellite repeat family that remains poorly understood despite its relevance to acrocentric chromosomes, epigenetic instability, and repeat-derived ncRNA. shorturl.at/SXdF4

The structure and regulatory biology of the SST1/NBL2 macrosatellite family

Primate-specific SST1/NBL2 macrosatellites are emerging as key components of human acrocentric chromosome biology. Here, we integrate historical mapping, telomere-to-telomere assemblies, and regulator...

cell.com

It is finally out! If you are interested in TE-derived CREs, and newly described, but evolutionary old KZFP-TE mechanistic modalities, read it at www.cell.com/cell-reports.... Thankful to everyone who took part in this work, namely @orpsf.bsky.social and other @trono-lab.bsky.social members. 🫀🧬✨

Tissue-specific restriction of transposon-derived regulatory elements safeguards cell-type identity

Milovanović et al. uncover a mechanism by which KZFPs restrict the activity of transposon-derived cis-regulatory elements to safeguard cardiomyocyte functionality. This work extends the classical TE-K...

cell.com

Our paper on the evolution of XIST regulatory network in primates is now published in Science Advances! Check out the paper www.science.org/doi/10.1126/... or a digest of our findings emmanuelczt.github.io/posts/2026/0... A short 🧵 of our main findings 👇

Remodeling of XIST regulatory landscape during primate evolution

How gene regulation strategies rapidly evolve across short evolutionary timescales is explored.

science.org

Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm! www.nature.com/articles/s41...

Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm - Nature Cell Biology

Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm.

nature.com

A new paper out in @natmethods.nature.com introduces NimbusImage, a cloud-computing platform for image analysis ft. William Niu (SAS), Jingxin Li (@cambupenn.bsky.social), @aofarrell.bsky.social (Bioengineering) & @arjunraj.bsky.social (@penngenetics.bsky.social) www.nature.com/articles/s41...

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

An integrated view of the structure and function of the human 4D nucleome - Nature

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...

nature.com

📢 Telomere community: Registration and abstract submission are now open for the EMBO Workshop “Telomere function and maintenance in health and disease”, May 25–30, 2026, in Lazise, Italy 🇮🇹. Looking forward to an exciting meeting! Please re-post. meetings.embo.org/event/26-tel...

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

Escape from X inactivation is directly modulated by Xist noncoding RNA

Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

rdcu.be

Excited to share that this work is now published in its final form! link.springer.com/article/10.1...

TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability - The EMBO Journal

The subcellular localization of many mRNAs to neuronal projections allows neurons to efficiently and rapidly react to spatially restricted external cues. However, for most of these RNAs, the mechanism...

link.springer.com

Matthew Taliaferro@jmtali.bsky.social · last yr.

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

Before you decorate the tree, come decorate your RNA next Thursday, 4 pm, 18.12.2025 Our last RNA event before the holidays. Also:Glühwein&snacks Registration: rmu-rna-salon.idloom.events/2-rmu-rna-sa... Please share @mixmue.bsky.social @cpi-exstra.bsky.social @scale-cluster-ffm.bsky.social

Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!