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Liz Heller

@eahellerphd.bsky.social

it was the blurst of times #epigenetics #addiction #blm https://hosting.med.upenn.edu/hellerlab/

106 Posts331 Follower369 Folgt
Talia Lerner@talialerner.bsky.social · 2d ago

🚨Happy to share a new preprint from Lerner Lab led by graduate student @nadelneurosci.bsky.social! 🚨 “Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking” This has been a wholly impressive effort by Jacob; summary below 👇 #neuroskyence🧪

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2d ago

Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking https://www.biorxiv.org/content/10.64898/2026.07.29.741478v1

Maxim Greenberg@maxvcg.bsky.social · 2d ago

Read this article, get excited, and come to the Epigenome Editing symposium! Marianne Rots, Charlie Gersbach, and Angelo Lombardo (all featured in the piece) will be there in person!! Registration only 50€, talks from abstracts, plus Paris 😜 @natureportfolio.nature.com www.nature.com/articles/d41...

Epigenetic editing makes its mark

Researchers are rewriting the chemical tags on DNA and chromatin to tune gene expression.

nature.com

Maxim Greenberg@maxvcg.bsky.social · 5mo ago

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

Flyer for symposium: https://ctrlepiedit.sciencesconf.org/
Wilma Marlene Fine ✈️@wmf5.bsky.social · 3mo ago

The supermarket that I shop at employs mentally challenged. They are greeters, baggers, and perform other functions. They are normally pleasant and happy to have a purpose. I like shopping there, it's a reminder that there's room in this world for all of us.

Keri Martinowich@martinowk.bsky.social · 4mo ago

And some love for the human 🧠 for #FluorescenceFriday. I like these zoom outs where you can see a whole structure - here, striatum. Green is MBP and outlining the white matter tracts, 🟣 is DRD1 and if you zoom in (see zooms in following posts) there is 🔴 for RXFP1 marking clusters of island cells.

Microscopy image of a section of human brain tissue at the level of the striatum with white matter fiber tracts outlined in bright green
Jacquelyn Gill@jacquelyngill.bsky.social · 4mo ago

I’ve always said that submitting a grant proposal is an exercise in hope—not just in terms of being funded, but as a symbol of what it means to dream big and ask exciting questions. Despite everything happening to federal science over the last year, I’m holding on to that hope. Proposal submitted.

Joshua Weitz@joshuasweitz.bsky.social · 5mo ago

The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.

Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302