Congratulations to Damien Glon and Quentin Riller on this fruitful collaboration between Yves Gaudin's team @cnrs-paris-saclay.bsky.social and our team @institutimagine.bsky.social . www.nature.com/articles/s41...

When pediatric lupus behaves like a Mendelian disease: #Monogeniclupus, @hcl-recherche.bsky.social @ciri-lyon.bsky.social, @frl-lab.bsky.social Important implications for personalized care👇 WES enables molecular diag in 10% of pediatric SLE cases eBioMedicine www.thelancet.com/journals/ebi...

Exome sequencing enables molecular diagnosis in 10% of early-onset or familial systemic lupus erythematosus cases

This study expands our understanding of causes of lupus, highlighting its genetic heterogeneity. It also supports the systematic use of genetic testing in cases of juvenile lupus, especially those wit...

thelancet.com

Don’t miss ➡️ #InSilicoModeling guides identification of novel #JAK1 variants associated with #ImmuneDysregulation By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social 🗞️ doi.org/10.1038/s443...

Open call for applications for the International PhD PPU-IMAGINE program! Don’t miss out on 16 different PhD research projects at Institut Imagine! Deadline: October 20, 2025 For more information: www.institutimagine.org/en/internati...

Congratulations @damien-glon.bsky.social ! Very happy to be involved in this study with @frl-lab.bsky.social ! 🔥

Damien Glon@damien-glon.bsky.social · last yr.

🚨Proud to share the preprint from my postdoc in Yves Gaudin’s lab, in collab with Frédéric Rieux-Laucat’s lab. 🧠Our key finding?
 NAP1 plays a dual role in regulating innate immunity. 📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies. 🔗⬇️

🚨Proud to share the preprint from my postdoc in Yves Gaudin’s lab, in collab with Frédéric Rieux-Laucat’s lab. 🧠Our key finding?
 NAP1 plays a dual role in regulating innate immunity. 📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies. 🔗⬇️

NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates

TBK1 kinase is a central regulator of type I IFN production. Upon activation of the IFN-β induction pathway, TBK1-adaptor proteins (NAP1, SINTBAD, TANK) form condensates with liquid properties. We sho...

biorxiv.org

@quentinriller.bsky.social, @frl-lab.bsky.social et al. present the first case of biallelic CHUK mutations disrupting IKKα kinase function, broadening the understanding of non-canonical NF-κB defects rupress.org/jem/article/... 📘 In Genes & Immunity collection: rupress.org/jem/collecti... #HKS2025

Thrilled to share our latest in @jem.org! 🚨 A single patient with syndromic immunodeficiency led us to uncover that biallelic point mutations in the IKKα kinase domain disrupt the non-canonical and partially the canonical NF-kB pathway activation. Dive into the details! 🧬 #NFkB #Immunology

Journal of Experimental Medicine@jem.org · 2y ago

Riller et al. @frl-lab.bsky.social @institutimagine.bsky.social show that IKKα kinase deficiency causes syndromic #immunodeficiency & immune dysregulation as a consequence of a major defect in the non-canonical NF-κB pathway and a partial defect in the canonical pathway. https://buff.ly/4gUZZZz

Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans @jem.org‪ @quentinriller.bsky.social @frl-lab.bsky.social doi.org/10.1084/jem....

Riller et al. @frl-lab.bsky.social @institutimagine.bsky.social show that IKKα kinase deficiency causes syndromic #immunodeficiency & immune dysregulation as a consequence of a major defect in the non-canonical NF-κB pathway and a partial defect in the canonical pathway. https://buff.ly/4gUZZZz

This work was done in @institutimagine.bsky.social in the laboratory of @frl-lab.bsky.social with Bénédicte Neven and collaborators in France and Belgium @casanovalab.bsky.social @anne-puel.bsky.social Many thanks to all co-authors!

Our massive effort to recontextualize #single #T-cell data is now out in Science Advances! We developed a new system, STEGO, to do a TCR-first analysis, and reanalyzed 12 studies and more than 500 000 individual T-cells. Supported by @cziscience.bsky.social ! doi.org/10.1126/scia...

T cell receptor–centric perspective to multimodal single-cell data analysis

T cell receptor–centric perspective improves single-cell analysis.

doi.org

Single-cell atlas of the human immune system reveals sex-specific dynamics of immunosenescence, including a female-specific cytotoxic CD8+ T cell subpopulation @martamele.bsky.social @mariasopenar.bsky.social papers.ssrn.com/sol3/papers....

How can we better explain that vaccination is the unique way to protect our children? And as said a brillant French pediatrician, Pr Robert Debré, long ago, our children are our eternity….

BK. Titanji@boghuma.bsky.social · 2y ago

10.3 million cases of measles occurred worldwide last year, up 20% from 2022, primarily because of inadequate immunization coverage. The disease resulted in 107,500 deaths last year, mostly killing children under 5!!!! There are no upsides to shunning vaccines. www.washingtonpost.com/health/2024/...

10.3 million cases of measles occurred worldwide last year, up 20% from 2022, primarily because of inadequate immunization coverage. The disease resulted in 107,500 deaths last year, mostly killing children under 5!!!! There are no upsides to shunning vaccines. www.washingtonpost.com/health/2024/...

Surge in worldwide measles cases driven by lack of vaccine coverage, WHO says

The WHO and CDC say there were about 10.3 million cases of measles last year, up 20 percent from 2022. Children are especially susceptible to complications.

washingtonpost.com

Recent paper (Nature)-why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? X/Y or hormones? We study adaptation of immune systems in gender-affirming testosterone treatment: nature.com/articles/s41...

Immune system adaptation during gender-affirming testosterone treatment - Nature

Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses...

nature.com