What exactly is happening where hard bone meets bone marrow? By mapping this poorly understood interface, Garvan researchers have newly identified hundreds of the genes involved. 🔗 Find out more here: https://ow.ly/OK4350ZwsGv
IMAGE Lab
@labphan.bsky.social
B cells | Macrophages | Immunity | Autoimmunity | Cancer | Osteoclasts | Osteomorphs | Intravital imaging | Precision Immunology
In 2014, Jason Rosch and I met at a GRC in Tuscany and sketched an idea on a cocktail napkin: what if we evolved S.pneumo in mice, treated them with antibiotics, varied their immune systems and watched what won? 11 years and a huge team effort later, it's out in @cp-cellhostmicrobe.bsky.social 🧵
Watched in awe as this epic evolved over many years & now out @natgenet.nature.com. Int'l team led @imperialcollegeldn.bsky.social, @garvaninstitute.bsky.social & TRI/UQ. What a high bar!Mouse to human, cells to gene, gene to function. Foundation for cancer, blood, immune diseases that involve bone!
Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease - Nature Genetics
The study integrates cross-species single-cell and genomic analyses with functional validations to map the endosteal bone compartment, revealing musculoskeletal-disease-relevant cell types and transcr...
nature.com
My career bumpily took off with a discovery that proved world-changing, and from there, an eclectic, eccentric and fairly entertaining life took shape. The science, the life, the collaborations that make discovery happen—that’s what Immune Beyond is about.
Max Krummel | Substack
Click to read Max Krummel, a Substack publication.
theimmunebeyond.substack.com
Amazing work congrats Allegra and team! Go @kseskv.bsky.social Precision Immunology @garvaninstitute.bsky.social !
Allegra Angeloni@angeloniallegra.bsky.social · 2mo agoOur work on 5mC reprogramming in the fat-tailed dunnart is now out in @natcomms.nature.com 🥳 huge thanks to our collaborators, and to the reviewers for their time and feedback! @kseskv.bsky.social @oligriffith.bsky.social doi.org/10.1038/s414...
Impressive impact of the WHO EPI 1974-2024. Last year we learnt over 50 years the EPI saved 154 million lives (incl. 146 million children <5 years). New data now shows every $1 invested in EPI returned $15 in economic benefit from lives saved. Invest in science!
Global, regional, and national impact of the Expanded Programme on Immunization against 14 pathogens from 1974 to 2024: an economic evaluation
2024 marked the 50th anniversary of the Expanded Programme on Immunization (EPI), launched by WHO. Despite its crucial role in preventing infectious d…
sciencedirect.com
Excited to announce our new study (w/ @maxkrummel.bsky.social) published today @nature.com: Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells. www.nature.com/articles/s41... #immunology #cellbiology @immunox.bsky.social
Submicrometre sampling of living cells by macrophages - Nature
Macrophages can sample antigens from living cells through a trogocytosis-like mechanism that routes ingested material away from degradation, a finding that delineates a previously unknown pathway...
nature.com
It's been a while time to give #immunology @bsky.app another go...Thrilled to share work led by Dr Yuki Keith & colleagues @garvaninstitute.bsky.social, UNSW & Melanoma Institute Australia now out @jem.org. CD169+ macs in skin surround & constrain melanoma growth independent of T and B cells! 1/2
CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin
Tissue-resident CSF1R-dependent CD169+ macrophages localize deep in the skin. They surround growing tumors and directly suppress their growth independent o
rupress.org
They do what? www.science.org/doi/10.1126/...
Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditions
Birds use a variety of navigational strategies, including the geomagnetic field, especially when other cues are not available, such as under overcast or nocturnal conditions. Magnetite particles in th...
science.org
📰 Researchers at @garvaninstitute.bsky.social have captured, for the first time, ‘housekeeping’ immune cells actively attacking and engulfing live #melanoma cells. 👉 www.garvan.org.au/news-resourc... Original study in @jem.org by Keith et al. @labphan.bsky.social 👉 rupress.org/jem/article/...
📰 Researchers at @garvaninstitute.bsky.social have captured, for the first time, ‘housekeeping’ immune cells actively attacking and engulfing live #melanoma cells. 👉 www.garvan.org.au/news-resourc... See the original study in JEM by Keith et al. @labphan.bsky.social 👉 rupress.org/jem/article/...
What better way to celebrate Mother's Day and World Lupus Day! New from @seyhanyazar.bsky.social @garvaninstitute.bsky.social together with Joseph Powell, Sara Ballouz and colleagues. SLE affects 9 women to every man. Yet they show most sex-DEG were on autosomes and not sex chromosome!
The impact of sex on the immune system explored at the single-cell level
Yazar et al. characterized sex-based immune differences at single-cell resolution using sex-differential expression (differentially expressed genes [DEGs]) and sex-stratified expression quantitative l...
cell.com
New research at Garvan offers new insights into why lupus affects 9 times more women than men #WorldLupusDay 👉Learn more: https://ow.ly/LjOY50YWUA9 #Lupus #AutoimmuneDisease #LupusResearch #LupusAwareness #MedicalResearch
Check out this cool new paper from Mike Rogers lab @garvaninstitute.bsky.social out in @cp-immunity.bsky.social! Their new model of MKD deficiency (aka Hyper IgD syndrome) as a "prenylopathy": NK cell degranulation defect -> compensatory increase IFN gamma -> autoinflammation. Can Rx with JAKi!
NK cell dysfunction and interferon gamma production underlie autoinflammation in mevalonate kinase deficiency
The mechanisms linking defective protein prenylation to systemic inflammation in mevalonate kinase deficiency remain unclear. Munoz et al. reveal that mice and humans with MKD have defective NK cells,...
cell.com
New study: @rosertp.bsky.social, Bashour, Filipska, et al (@victorgreiff.bsky.social & Cerutti labs, Uni Oslo & @researchmar.bsky.social) show IgD responses involve a heterogenous pop. of IgD class-switched memory #Bcells from epithelial areas of aerodigestive mucosa. rupress.org/jem/article-...
We are excited to welcome Dr Carlson Tsui to the Garvan Faculty. A rising leader in cellular immunology, Dr Tsui will establish his lab within our Precision Immunology Program, focusing on unlocking the regenerative potential of the immune system. https://ow.ly/cpiw50YAtec
Pick your challenge. Go4Garvan. Power life-changing medical research. Find out how you can Go4Garvan here: bit.ly/Go4Garvan
Ok this is next level insane! Molecular recording with minimal impact on transcript abundance and gene function! www.science.org/doi/epdf/10....
A genetically encoded device for transcriptome storage in mammalian cells
Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...
science.org
If in Sydney don't miss the #free 2025 Australian Geographic Nature Photographer of the Year exhibit at the Australian Museum! The photos are breathtaking & Ross Gudgeon’s Fractal Forest inside-out macro of a soft cauliflower coral was mind blowing! Though... @ausgeo.newsmast.social.ap.brid.gy
2025 Australian Geographic Nature Photographer of the Year
See nature in a whole new light in this stunning, photographic exhibition, featuring works by some of the world's best nature photographers.
australian.museum
The Szilard Point is not some theoretical event horizon. It is where we are at right now. When the total cost of competing for a grant exceeds the value of available funding the system is seriously broken. We need innovative granting schemes and solutions not more of the same hunger games.
Point of no returns: researchers are crossing a threshold in the fight for funding
With so little money to go round, the costs of competing for grants can exceed what the grants are worth. When that happens, nobody wins.
nature.com
Beautiful work congrats everyone!
Michela Locci@michelalocci.bsky.social · 8mo agoI am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...
These 2 landmark papers came out at the start of my PhD. Science and clinic. Literally back to back. It has been an enduring inspiration ever since to be a part of this wonderful experiment called immunology.
Center for Cancer Immunotherapy and Immunobiology@ccii-kyoto.bsky.social · 8mo agoIn a @cp-cell.bsky.social Benchmarks article, Masamichi Muramatsu, Sidonia Fagarasan et al tell the story of the discovery of AID in the Honjo lab, solving the decades long mystery of the molecular effector of Ig class switch recombination and somatic hypermutation. #Immunology
AID's role in class switch recombination & somatic hypermutation was published in @cellpress.bsky.social 25 years ago, a tour de force combo of mouse gene discovery & mechanistic work (Honjo lab) and human genetics (Durandy, Fischer et al). What a privilege to write this with Sidonia & Masamichi
Activation-induced cytidine deaminase: The missing piece of many puzzles
Twenty-five years ago, two Cell papers reported the key missing functional piece in three molecular puzzles. The genetic swapping of immunoglobulin constant regions, the mutational fine-tuning of anti...
cell.com
This is next level out of this world! Disease agnostic in vivo prime editing! www.nature.com/articles/s41...
Prime editing-installed suppressor tRNAs for disease-agnostic genome editing - Nature
A new strategy that uses prime editing to convert an endogenous tRNA into a suppressor tRNA shows therapeutic potential for multiple genetic diseases that are caused by premature stop codons.
nature.com
Looking forward to this see you there Deepta!
Deepta Bhattacharya@deeptabhattacha.bsky.social · 9mo agoI’m co-organizing a Keystone conference on B cells and plasma cells with Kim Good-Jacobson and Taras Kreslavsky! Deadlines for abstracts and scholarships is Nov 13. Great lineup of basic, translational, and industry speakers. Please repost! www.keystonesymposia.org/conferences/...
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...
Out @nature.com led by @jdegregori.bsky.social Mercedes Rincon @roelvermeulen.bsky.social @jaguirreghisolab.bsky.social et al. in vivo mouse models & human data show resp. infections drive IL-6 dependent re-awakening of dormant cancer cells in lung. So much to like about this paper! Congrats all!
Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature
Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...
nature.com
Very excited at the chance to work with new people with new ideas in immunology! Really keen to hear from people from diverse backgrounds with different ways of thinking. International applicants seeking freedom to pursue BlueSky projects welcome. Come for the science. Stay for the vibe! #immunosky
Dr Elissa Deenick@elissadeenick.bsky.social · last yr.The Precision Immunology and Immune Biotherapies Programs at the Garvan Institute are looking for new Faculty members. Come join us and work with amazing scientists in an amazing place @labphan.bsky.social @garvaninstitute.bsky.social www.nature.com/naturecareer...
Now online in Cancer Discovery: AAnet Resolves a Continuum of Spatially-Localized Cell States to Unveil Intratumoral Heterogeneity - by Aarthi Venkat, Scott Youlten, Beatriz San Juan, Smita Krishnaswamy, Christine Chaffer, and colleagues doi.org/10.1158/2159...
