Interesting link between aging, serotonin, platelets and COVID-19 severity. A new study in Science Immunology from @iannaconelab.bsky.social and colleagues identifies platelet-derived serotonin as a driver of age-related lung pathology following SARS-CoV-2 infection. www.science.org/doi/10.1126/...

Platelet-derived serotonin drives age-related lung pathology in SARS-CoV-2 infection

In aging hosts, platelet serotonin fuels lung-damaging clots, leading to enhanced respiratory distress in the context of COVID-19.

science.org

Editors dinner and a glimpse of last night’s eclipse in Cambridge ☀️🌙 @immunoeditor.bsky.social @smhsci.bsky.social @science.org @sciimmunology.bsky.social @drkeithsmith.bsky.social @sarahhross.bsky.social

One of the largest U.S. studies ever conducted on more than 2.5 million children reaffirms that there is NO association between receiving the first MMR vaccine before age 2 and childhood autism 💉 www.ovid.com/jnls/pidj/ab... www.the-independent.com/bulletin/new...

In this month’s #ScienceImmunology special issue: @maurogaya.bsky.social and team find that barrier tissue-specific cues influence B cell receptor isotype usage, shaping the memory response. Read more here: www.science.org/doi/10.1126/...

Mucosal tissue cues shape B cell memory through the IgA BCR

Divergent B cell memory strategies evolved in lung and gut mucosa to counteract recurrent pathogens.

science.org

#Science #Immunology turns 10 years old this month! We celebrate w/ a Special Issue on immune #memory! Check out our 3 outstanding Reviews by Maziar & Kaufmann; @sjturn.bsky.social, Thiele, & @niclag.bsky.social; & @maurogaya.bsky.social & @kimljacobson.bsky.social out this week! scim.ag/448rEkV

On the April cover of #ScienceImmunology: The brain’s perception of hunger (rather than nutrient availability) regulates circulating immune cell dynamics. Read more here: www.science.org/doi/10.1126/...

Science Swifties this is a must-read 🤩

Eberl Lab 👨🏻‍🔬👩🏽‍💻🔬🧫@eberllab.bsky.social · last yr.

Are you ready for it? "Highlights of 2024: γδ T cells and bad blood" A summary of the emerging regulatory and effector roles of #gdTcells in #sepsis. And it may also contain a few Taylor Swift references. More than 50 in fact. Thank you so much @immunolcellbiol.bsky.social for playing along!

In #Science #Immunology this week: human naïve B cells can bind and neutralize #H5N1, potentially offering protection against #birdflu.

Human naïve B cells recognize prepandemic influenza virus hemagglutinins

Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.

science.org

I’ll be here (joint with T cell Differentiation in Tissue Microenvironments) next week! Send me a message or email if you’d like to set up a time to chat. Looking forward to an exciting meeting!

Keystone Symposia@keystonesymposia.bsky.social · 2y ago

Catch @drshrutinaik.bsky.social, @labfairfax.bsky.social, @ostunilab.bsky.social and Yasmine Belkaid for Innate Immune Memory. Submit your abstract for a poster presentation spot by Jan. 9th (11:59pm MST)! keysym.us/KSInnateImmu... #KSInnateImmune25 #keystoneconferences #innateimmunity

New review out in #science #immunology on tuberculosis immunopathology by @tomscriba.bsky.social et al.🫁🦠 www.science.org/doi/10.1126/...

Immunopathology in human tuberculosis

The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.

science.org

This week in #ScienceImmunology: Germinal Center B cells require asparagine (Asn) #metabolism for their function. GC B cells can acquire exogenous Asn from their local environment, but when Asn is limited, they utilise the enzyme asparginine synthetase. @ajclarke.bsky.social @yfy1.bsky.social

Asparagine availability controls germinal center B cell homeostasis

Asparagine metabolism is a critical regulator of germinal center B cell function.

science.org

Thrilled to share our latest work on how the non-essential amino acid #asparagine metabolically regulates germinal centers. Huge thanks to my PhD supervisor @ajclarke.bsky.social, colleagues, and collaborators at the @ndorms.bsky.social @ox.ac.uk and @crick.ac.uk www.science.org/doi/10.1126/...

Asparagine availability controls germinal center B cell homeostasis

Asparagine metabolism is a critical regulator of germinal center B cell function.

science.org

Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9

🙏 to @niaidnews.bsky.social, first author @pauljbaker.bsky.social and my amazing lab team, our collaborators @kerryhilligan.bsky.social @danbarberphd.bsky.social 🙏to editor extraordinaire @hannah-isles.bsky.social and the reviewers who guided us along the way 9/9 www.science.org/doi/10.1126/...

The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication

Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.

science.org

Two new studies in Science describe synthetic biology-based strategies that expand the possibilities of harnessing immune cells to treat disease. Learn more in this week's issue: scim.ag/49nfztS

Now in #Science #Immunology: Ziang Zhu, Tuoqi Wu, Chen Yao et al at UT Southwestern show that #NRF2 suppression mediated by the #redox sensor #KEAP1 is required for optimal expansion of #CD8 #TCells during chronic antigen exposure!

The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation

KEAP1 promotes persistent T cell immunity and a stem-like T cell response during chronic antigen stimulation by repressing NRF2.

science.org

By popular demand @science.org is on Bluesky!! No posts until after Thanksgiving, but stand by! @karaestellepowers.bsky.social @kakape.bsky.social @jakeyeston.bsky.social

New in #ScienceImmunology: Research from @boztugk.bsky.social and team identifies an inborn error of #immunity caused by human LTβR deficiency, resulting in defective stromal cell signaling and impaired humoral immune responses. Read more: www.science.org/doi/10.1126/...

LTβR deficiency causes lymph node aplasia and impaired B cell differentiation

Loss-of-function mutations in LTBR result in a stromal defect, leading to dysfunctional secondary lymphoid organs and combined immunodeficiency in humans.

science.org

Last week in #ScienceImmunology: An alternative approach to target TIM-3 for cancer #immunotherapy? Zhang et al. found that palmitoylation of human TIM-3 promoted its stability. Blocking palmitoylation accelerated TIM-3 degradation, prevented immune #exhaustion and promoted anti-tumor #immunity

Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity

Targeting TIM-3 palmitoylation mediated by DHHC9 enhances CAR-T cell– and NK cell–based tumor immunotherapy by suppressing immune exhaustion.

science.org

Fantastic visit to @cambridgeuni.bsky.social pathology department today. Lots of exciting science and beautiful place to visit 🧪 thanks to @labliston.bsky.social for hosting!

At #ScienceImmunology, I lead a fantastic team of #research #editors comprising Chris Fogg (@cnfogg.bsky.social), Claire Olingy (@claireolingy.bsky.social), and Hannah Isles (@hannah-isles.bsky.social)! Be sure to give them a follow! www.science.org/journal/scii...

New here 🙋🏻‍♀️

James O’Brien@mrjamesob.bsky.social · 2y ago

www.theguardian.com/technology/2...

let's do this!! I am excited to reconnect with scientists here. thx @oneyrolles.bsky.social for the push 😀 #Immunology announcement: SAVE THE DATE: 26-29 August in Basel 🇨🇭 Mauro Gaya (CIML) and I are organizing an #EMBO workshop on Adaptive #immunity in barrier tissues; details coming soon!