A Modular Platform for Purification of Organelle-associated Mitochondria Reveals Functional Specialization at Organelle Contact Sites

Mitochondria perform diverse metabolic and signaling functions, yet how these activities are spatially organized within the mitochondrial network of cells remains poorly understood. Organelle contact ...

biorxiv.org

ER cholesteryl ester phase separation underlies switch-like cholesterol sensing

Cellular lipid homeostasis requires mechanisms that detect subtle changes in lipid abundance and trigger rapid, coordinated responses. The INSIG/SCAP/SREBP2 pathway provides a central feedback system ...

biorxiv.org

Cellular lipid imaging at the ultrastructural level

Lipids are fundamental organizers of biological membranes, yet visualizing lipid species within subcellular organelles has remained beyond experimental reach. Lennartz et al. introduce Lipid-correlati...

cell.com

Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer’s disease - Nature Neuroscience

Researchers identify mitochondrial plaques, a previously unrecognized and highly acidic mitochondria-based pathological structure in Alzheimer’s disease, and demonstrate that they result from the dual...

nature.com

Gravitational and mechanical forces shape mitochondrial translation - Nature Communications

In this study, microgravity was found to disrupt mitochondrial translation through inhibition of laminin–integrin signaling and the downstream pathway, which is usually activated by mechanical stress.

nature.com

ATAD3A structurally links mtDNA replication and mitochondrial fission

Mitochondrial function depends on the maintenance of its genome, and disruptions in copy number and distribution are hallmarks of mitochondrial disorders. Mitochondrial DNA (mtDNA) replication is spat...

doi.org

Investigating the relationship between ATP synthase and the TCA cycle by crosslinking mass spectrometry - Nature Communications

Mitochondria convert nutrients into ATP through coordinated molecular machines and metabolic pathways. Here, the authors show that ATP synthase contacts TCA cycle enzymes in mouse heart and that defec...

nature.com

Retrograde mitochondrial transport is required for mitochondrial biogenesis in zebrafish neurons - Nature Communications

Lang et al. use larval zebrafish neurons to show that the axonal retrograde transport of mitochondria is required to activate mitochondrial biogenesis through NAD + /Sirt1/Estrogen-related receptor me...

nature.com

Mitochondria directly interact with the nuclear pore complex - Nature

Mitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels.

nature.com

Functional specialization within the mitochondrial network: Are all mitochondria created equal?

Mitochondria are classically viewed as a uniform ATP-producing network; however, a growing body of evidence suggests distinct subpopulations exist within tissues and even single cells. Here, I highlig...

cell.com

TDP-43 oxidation and PP1 crosstalk at RNA granule-mitochondria contact sites - Nature Communications

TDP-43 localization is disrupted in ALS and FTD. Here, authors find that TDP-43 oxidation via mitochondrial OXPHOS mediates its localization to RNA granules, regulating RNA granule-mitochondria contac...

nature.com

biorxiv.org

Microtubule dynamics control the direction of cardiomyocyte growth

The adult heart grows by the addition of sarcomeres along the length or width of individual cardiomyocytes, yet how directional growth is spatially coordinated remains unclear. We found that microtubu...

science.org

MICU proteins facilitate calcium-dependent mitochondrial metabolon formation to regulate cellular energetics independently of MCU

Nature Metabolism, Published online: 13 May 2026; doi:10.1038/s42255-026-01513-zThis study describes a novel mechanism of calcium control of metabolism found in the mitochondrial intermembrane space that is entirely independent of matrix Ca2+ uptake.

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Metformin lowers blood glucose by targeting intestinal mitochondrial complex I

Nature Metabolism, Published online: 08 May 2026; doi:10.1038/s42255-026-01532-wMetabolomic analysis of plasma from metformin-treated humans, together with mechanistic studies in mouse models, reveals that metformin selectively inhibits mitochondrial complex I in the intestinal epithelium. This mechanism unifies multiple clinical effects of metformin, including enhanced intestinal glucose use, improved postprandial glycaemic control and increased production of GDF15 and N-lactoyl-phenylalanine.

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TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency

Using carbon tracing and functional experiments, Kafkia, Pladevall-Morera, et al. show that TCA cycle rewiring underlies mouse embryo implantation and the exit from naive pluripotency. In this context, pyruvate cycling enables timely cell-state transitions, while, coupled to it, reductive glutamine metabolism fuels the histone acetylation backbone.

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How to design effective scientific figures

Nature Human Behaviour, Published online: 01 May 2026; doi:10.1038/s41562-026-02466-9Scientific figures strongly influence how research findings are interpreted, yet guidance on figure design has largely focused on technical aspects of visualization. In this ‘How to’ Comment, I outline a practical strategy for creating figures that communicate clearly across audiences and scientific contexts.

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