Admired for its regal blue lace-like crest and mesmerizing red eyes. The Victoria Crowned Pigeon, native to New Guinea, is the world's largest living pigeon. Its graceful beauty and deep calls make it one of the region's most remarkable birds. Scientific Name Goura victoria 📷 B. Sharma

Hey team - it’s looking very likely that I’ll be hiring not one but two four year postdocs! We’re a fun lab with tons of theoretical and applied pop gen projects - broadly in polyploid, conservation, and human evo. Competitive salary, sunny San Diego! Do share with your about to defend grads!

My personal summer of code continues with another ChimeraX plugin - this time, MorphometricsX! Load quantified meshes from morphometrics (or pycurv) in ChimeraX with color-by-quantification and display alongside tomos and particles. Coming to the toolshed soon! #teamtomo github.com/baradlab/mor...

Incredibly proud of Messi Haile @mehsehret.bsky.social, a founding member of the Ho Lab, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in @cellpress.bsky.social! tinyurl.com/4p3md2eb 🦠❄️🔬

Really hyped to share our pre-print on mtDNA replication-fission ! @nanigrotjahn.bsky.social (doi: doi.org/10.64898/202...) 🧵with details below ⤵️

ATAD3A structurally links mtDNA replication and mitochondrial fission

Mitochondrial function depends on the maintenance of its genome, and disruptions in copy number and distribution are hallmarks of mitochondrial disorders. Mitochondrial DNA (mtDNA) replication is spat...

doi.org

Quartz, Amethyst, Hematite slice from India Sold www.goldenhourminerals.com

This amazing work by @danialv.bsky.social and Bodan Hu is now out in peer-reviewed form at @cp-cell.bsky.social with a lot of new simulations! Check it out if interested in lipid transport!

Vanni Lab at UNIFR, Switzerland@labvanni.bsky.social · 7mo ago

Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7) www.biorxiv.org/content/10.6...

the world needs more guinea pig cartographers

Easymode: general pretrained networks for cellular cryo-ET enable flexible approaches to subtomogram averaging https://www.biorxiv.org/content/10.64898/2026.05.19.726344v1

In @jcb.org, Covill-Cooke, Hirashima, Kawano, Endo, Kornmann (@ox.ac.uk) and colleagues find that the ERMES #lipid-transporting complex, long-thought to be an obligate heterotetramer, can be replaced by only one component: mitochondrially tethered Mmm1. rupress.org/jcb/article/... #Mitochondria

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

The Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI

Mitochondria can indeed be inherited from the father! 🍀 In this new study, we uncovered the molecular mechanisms underlying mitochondrial inheritance in Nicotiana tabacum. @natplants.nature.com doi.org/10.1038/s414...

High-frequency biparental inheritance of plant mitochondria upon chilling stress and loss of a genome-degrading nuclease - Nature Plants

Maternal inheritance of mitochondria breaks down in the cold when a mitochondrial DNA degrading nuclease is defective, resulting in biparental inheritance that can rescue mitochondrial mutations and g...

doi.org

Since last year, I've been making a RELION GUI that supports viewing, navigating and running jobs in a way completely compatible with the original RELION pipeline. Now it's working nicely for both SPA and tomography! Please try it out - github.com/hanjinliu/hi...

Super exciting to see this preprint come out! It’s been a wonderful opportunity to be a part of this story and to apply Surface Morphometrics tooling to a fascinating system. Congratulations to all authors @wilflinglab.bsky.social #teamtomo

Wilfling Lab@wilflinglab.bsky.social · 7mo ago

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET

Our new paper (with @biotay.bsky.social) is out and on the cover story of @currentbiology.bsky.social !!!! Veronika, a Carinthian mountain cow flexibly uses a “multi-purpose tool” to scratch herself. A video and more information will follow in the comments. www.cell.com/current-biol...

Happy new year #teamtomo! We've resumed our OHSU tomo journal club, and this year I am going to be sharing it on bluesky. This week we did a roundtable, where attendees each brought a paper and did a 3-5 minute discussion of what they thought was cool about it. Here are the papers they discussed!

Medina, Chang et al. of the @nanigrotjahn.bsky.social lab introduce a new method based on the Surface Morphometrics pipeline to measure global and local thicknesses of organellar #membranes from cellular cryo-electron tomography data. rupress.org/jcb/article/... #CryoET

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

bioRxivpreprint@biorxivpreprint.bsky.social · 8mo ago

Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1

1/Now published! We identify a novel regulatory layer underlying SOS response dynamic. Find a short summary about our findings below. journals.plos.org/plosbiology/... #MicroSky

Variability in intrinsic promoter strength underlies the temporal hierarchy of the Caulobacter SOS response induction

The bacterial SOS response unfolds in a defined temporal order, but the determinants of this hierarchy are unclear. This study shows that intrinsic promoter strength, modulated in part by sigma factor...

journals.plos.org

🔬🥟 What do empanadas and #mitochondria have in common? More than you'd think. Our "empanada-shaped" cells just helped uncover hidden subpopulations of mitochondria in your everyday, unpolarized cell lines. Curious how mitochondrial trafficking shapes network health?

Extremely grateful to have had the opportunity to present my CryoET adventures in the grotjahn lab at #cellbio2025. We can all agree that the CryoEM and CryoET session was the best. It was wonderful to meet old mito besties, NCBS besties and make new besties. 😌

Oxidative phosphorylation complexes contain subunits encoded by both the nuclear and mitochondrial genomes. How do cells coordinate the synthesis and assembly of these complexes at the inner membrane? We teamed up with Martin Ott (@mitolab.bsky.social) to address this in two recent papers.

Just installed Doppio on our Linux machine. This is awesome work making relion more accessible and easy to run. I haven't tried submitting jobs yet but it is already making our live easier! I met Matt Iadanza at the CZI but I guess he doesn't have bluesky to tag!

Sjors Scheres@sjorsscheres.bsky.social · 9mo ago

At some point, Doppio will replace relion's gui. Already you can do more in Doppio than in relion! 🤩

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice @natcomms.nature.com @ryanlab.bsky.social @tcddublin.bsky.social @universitypress.cambridge.org www.nature.com/articles/s41...

CryoSift is now out @actacrystf.iucr.org doi.org/10.1107/S205... Thanks to all involved. Happy processing!

CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection

CryoSift is a CNN-based tool that assesses the quality of 2D class averages. The incorporation of CryoSift into cryoSPARC workflows enables automated particle-stack cleaning.

doi.org

Jan-Hannes Schaefer@jhschaef.bsky.social · last yr.

Check out our new preprint from the @landerlab.bsky.social, Stagg-Lab and Cianfrocco-Lab: CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selection www.biorxiv.org/content/10.1... Happy testing: cryosift.org #cryoEM #CNN

Exciting !

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 9mo ago

BRET-Based Mitochondrial Subcompartment Localization Biosensors https://www.biorxiv.org/content/10.1101/2025.10.27.684728v1

I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)

mStayRose is published in JBC 🥳🎉 Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable: www.jbc.org/article/S002...

StayRose: a photostable StayGold derivative red-shifted by genetic code expansion

Photobleaching of fluorescent proteins often limits the acquisition of high-quality images in microscopy. StayGold, a novel dimeric green fluorescent protein recently monomerised through sequence engi...

jbc.org

Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Lots of excellent work inside incl. Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.