Our new preprint introduces ✨ICONIC✨: an R package making causal inference accessible for observational omics. It unifies genetic instruments (Mendelian randomization) and negative controls (proximal inference) for mediation analysis under unmeasured confounding. www.medrxiv.org/content/10.6...

ICONIC: An R Package for Integrating Instrumental Variable- and Negative-Control-Informed Causal Discovery and Diagnostics in Multiomic Studies

Unmeasured confounding threatens causal inference and replicability in observational multi-omic studies across variable environments. Genetic instrumental variables (Mendelian randomization) and negat...

medrxiv.org

Ever wanted to interrogate fusion gene expression at single-cell resolution? Turns out, you can! 🧬 A fun collaboration with the Oshlack lab, spearheaded by Jovana Maksimovic, and a huge team effort! Check out our preprint 👇 @jovmaksimovic.bsky.social @aliciao.bsky.social @10xgenomics.bsky.social

Jovana Maksimovic@jovmaksimovic.bsky.social · 2d ago

Gene fusions drive ~16% of all cancers & 50-70% of childhood ALL. But standard scRNA-seq can't see them — the assays aren't built to capture fusion breakpoints. We built a way to fix that. @aliciao.bsky.social @sadras-t.bsky.social @petermaccc.bsky.social @onjcri.org.au @10xgenomics.bsky.social 🧵

Making visible what's always been true. Underrepresented genders are part of this community — and always have been. Our new name RLadies+ makes that clearer than ever. Join us → rladies.org #RLadies #RStats

Finishing your PhD, or thinking of starting one? The Conesa Lab (I2SysBio, CSIC–UV, Valencia) hosts PhD students and postdocs on competitive personal fellowships: long-read transcriptomics, single-cell, multi-omics, ML for genomics. Calls close Sep 2026–Apr 2027. → conesalab@csic.es

One of the major pains of academia is having to click through labyrinths of webpages to submit papers. Now, thanks to Joe Rich (and AI), problem solved! His tool is called PaperPush and is available at github.com/pachterlab/p... It's super easy to use! 1/🧵

GitHub - pachterlab/paperpush

Contribute to pachterlab/paperpush development by creating an account on GitHub.

github.com

💯 this!!!

James Ferguson@psy-fer.bsky.social · 3d ago

My problem is journals still pushing "print" limitations on online only publishing and charging me for it. Having to put things in the Sups because it doesn't fit in their limits. I always found the most interesting things in the Sups as they always contained the cool technical stuff.

Gene fusions drive ~16% of all cancers & 50-70% of childhood ALL. But standard scRNA-seq can't see them — the assays aren't built to capture fusion breakpoints. We built a way to fix that. @aliciao.bsky.social @sadras-t.bsky.social @petermaccc.bsky.social @onjcri.org.au @10xgenomics.bsky.social 🧵

bioRxivpreprint@biorxivpreprint.bsky.social · 3d ago

Closing the fusion-detection gap in single-cell RNA-seq with a scalable, probe-based workflow https://www.biorxiv.org/content/10.64898/2026.08.26.747171v1

World-leading Aussie science fighting #AntimicrobialResistance! PhD student George Bouras added 17M bacterial protein predictions to the #AlphaFold database. This was made possible by a partnership between BioCommons & @pawseycentre.bsky.social to containerise #ColabFold on Setonix. Read more 🔗

World-leading Australian science: 17M protein structures added to the AlphaFold Database to accelerate the fight against antimicrobial resistance  — Australian BioCommons

Australian researcher, George Bouras, has recently contributed an extraordinary 17 million protein predictions to the AlphaFold Protein Structure Database. This work was possible thanks to the availability of the ColabFold tool on Setonix AMD, the result of collaboration between BioCommons and the P

biocommons.org.au

Enjoying some sunshine ☀️ and science 🧪🧬 in Brisbane at the @cancerbioinfoau.bsky.social conference! Come and say hi at poster 27 - especially if you want to know how to easily detect fusion transcripts in single cells! #CBA2026

Been years since I commuted to work. Off to the @cancerbioinfoau.bsky.social conference today in Brisbane. Still working out what #ConferneceSwag we will have #illumina #bioinformatics #DRAGEN

📢 MIG Seminar: From Single Cells to Clinical Insights: Spatial Multi-Omics and the Future of Precision Oncology 🗓️ Fri, May 29 | ⏰ 12 - 1 pm AEST 📍 Agar Theatre (G003), Biosciences 4 (147) 🎙️ Associate Professor Arutha Kulasinghe, University of Queensland 🧍‍♂️In-person only #Immunotherapy #Biomarkers

MIG Seminar: Associate Professor Arutha Kulasinghe, University of Queensland

Title: From Single Cells to Clinical Insights: Spatial Multi-Omics and the Future of Precision Oncology Abstract Resistance to immunot...

events.unimelb.edu.au

📢 MIG Workshop: Multivariate analysis for omics data 🗓️ Thur, Jun 4 | ⏰ 9:30 am - 12:00 pm AEDT 📍 Online Event 🎙️ Prof. Kim-Anh Lê Cao 💰 Booking fee fully refunded #MultiOmics #DataIntegration #mixOmics #R

MIG Workshop: Multivariate analysis for omics data

About the Event Technological improvements have allowed for the collection of data from different molecular compartments (e.g. gene expression,...

events.unimelb.edu.au

Pipeline release! nf-core/raredisease v3.0.0 - 3.0.0 - Mario! Please see the changelog: https://github.com/nf-core/raredisease/releases/tag/3.0.0

Release 3.0.0 - Mario · nf-core/raredisease

What's Changed nf-test for subworkflows - I by @ramprasadn in #695 Important! Template update for nf-core/tools v3.3.2 by @nf-core-bot in #712 Resolve inconsistencies in schema JSON definitions by...

github.com

Today, on #InternationalNursesDay, we celebrate the extraordinary nurses at Peter Mac and beyond. Our #nurses provide some of the most specialised cancer care in the world - constantly pushing the boundaries of what exceptional cancer care looks like.

We have colleagues who put their blood, sweat and tears into detailed proposals for this funding scheme, only to find out they will all go in the bin. We still have no clarity on what ARC funding schemes are going to look like next year either. www.abc.net.au/listen/progr...

Australian science under strain - ABC listen

Australia’s research potential is not matched by funding. Belinda Smith speaks to scientists impacted and science minister Tim Ayres responds.

abc.net.au

ARC Tracker@arc-tracker.bsky.social · 4mo ago

This isn’t the ARC, but I can easily imagine it happening to an ARC scheme: The Government cancelled the Australia’s Economic Accelerator scheme, **including the round of submitted proposals currently under review**. Absolutely gutting for researchers involved. Enraging, and outrageous!

The high-speed logistics of a lung cancer cell. Watch GFP-Rab25 (Gold) move cargo through the internal recycling pathway of A549 cells. Static maps are great, but time-lapse shows the real traffic. Want your science/tech to be highlighted? DM me at Viroscope!

SpatialBench: Comparative cross-platform benchmarking of high-resolution spatial transcriptomics using matched mouse lymphoid tissue #SingleCell 🧪🧬🖥️ https://www.biorxiv.org/content/10.64898/2026.04.29.721531v1

roxygen2 8.0.0 out now: opensource.posit.co/blog/2026-05... ! So many goodies in this release including S7 support, tons of R6 improvement, a new config style, fewer dependencies, and so so many bug fixes #rstats

roxygen2 8.0.0

roxygen2 8.0.0 is now on CRAN, with first-class support for S7, a bunch of R6 improvements, a new configuration style, and a slimmer dependency footprint.

opensource.posit.co

🚀 We’re excited to share the release of Bioconductor 3.23, featuring: ✅2418 software packages (94 new) ✅437 experiment data packages (5 new) ✅928 annotation packages ✅8 books (2 new) ✅28 workflows 🔗 Please see the full release announcement here: bioconductor.org/news/bioc_3_...

🤯🤯🤯

Amy C Fan (she/her)@amycfanphd.bsky.social · 4mo ago

Excited to announce our new study (w/ @maxkrummel.bsky.social) published today @nature.com: Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells. www.nature.com/articles/s41... #immunology #cellbiology @immunox.bsky.social

We're looking for a postdoctoral fellow to work at the intersection of ecology and data science 🧪 www.tepunahamatatini.ac.nz/posts/postdo... #movingtonewzealand #movingtonz

Postdoctoral fellowship in ecology and data science

Join the Centre for Sustainability Research at the University of Otago as a postdoctoral research fellow in ecology and data science.

tepunahamatatini.ac.nz

We are recruiting a PI in biomedical data science at @bakerresearchau.bsky.social in Melbourne! A fantastic opportunity and do get in touch if any q's! www.seek.com.au/job/91619982...

Laboratory Head in Biomedical Data Science Job in Melbourne VIC - SEEK

Lead a biomedical data science lab, secure funding, publish research and collaborate globally to drive impactful cardiometabolic outcomes.

seek.com.au

🚀 After BioC2026 in Seattle, we’ll host a Bioconductor hackathon for the two days following the conference. This is a great opportunity to collaborate, build, and contribute to open-source bioinformatics projects. 📅 13–14 Aug 2026 Find more info here: bit.ly/4sHMe5m Apply here: bit.ly/4cuQQpr

BiocNA2026 Hackathon Participation

A Bioconductor-themed hackathon is going to held in the two days after Bioc North America (August 13th and 14th). If you are interested in attending, please supply some brief information about your…

bit.ly

Blog post on "The AI Rewrite Dilemma": lh3.github.io/2026/04/17/t...

Embrace laziness 😴 "Laziness drives us to make the system as simple as possible (but no simpler!) — to develop the powerful abstractions that then allow us to do much more, much more easily."

Hadley Wickham@hadley.nz · 5mo ago

Somewhat relevant: bcantrill.dtrace.org/2026/04/12/t...

Mapping nerves in a whole embryos. We find that across species and development stages, embryonic nerves display (beautiful) fractal geometry. More here: www.biorxiv.org/content/10.6...

The almost best thing about this is that Bioinformatics Twitter is back!

Phil Ewels@ewels.bsky.social · 5mo ago

Super excited to be launching two things today: #RustQC 🦀🧬 and rewrites.bio 🚀 I used AI to rewrite 15 RNA-seq QC tools into a single Rust binary (I've never written any Rust). It ended up being over 60x faster. Here's the story 🧵 seqeralabs.github.io/RustQC/

I've made a blogpost with a comprehensive list of all #Python data viz tools and libraries, for anyone wanting to try them out for the #30daychartchallenge Check them out! #DataViz #DataVisualization medium.com/@wajdi.ben.s...

The Complete Guide to Python Data Visualization Libraries

Python has become the go-to language for data visualization, and for good reason. Its ecosystem offers a tool for every situation, whether…

medium.com

Female octopuses throw rocks at males that bother them, documented in Octopus tetricus