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Mekhail Lab at U. Toronto 🍁🇨🇦

@karimmekhail.bsky.social

Explorers of nuclear/genome organization & stability, chromatin, RNA-DNA crosstalk, ribosome biogenesis, AI, cancer, and aging (basic to translational research). www.mekhaillab.com

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Mekhail Lab at U. Toronto 🍁🇨🇦@karimmekhail.bsky.social · 2w ago

😊 New preprint! In budding yeast, Dna2-intrinsic condensation regulates long-range DNA-end resection. Analyses suggest redistribution of condensate grammar in humans. Congrats to Chris Jordan and the Mekhail, Wyatt, Cowen & Hakem labs! More to come soon. www.biorxiv.org/content/10.6...

Dna2-intrinsic condensation regulates DNA end resection and reveals evolutionary redistribution of condensate grammar

Eukaryotic cells commonly use biomolecular condensation of DNA double-strand break (DSB) repair scaffolds and signaling assemblies to organize repair reactions in space and time. Yet whether DSB end-p...

biorxiv.org

Molecular Cell @cp-molcell.bsky.social · last yr.

Online Now: Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51 Online now:

Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51

Merigliano et al. identified a non-canonical, “off-pore” role for nucleoporins in genome stability and in the spatial regulation of homologous recombination in multicellular eukaryotes. Nup98 condensates form at DNA breaks within pericentromeric heterochromatin to prevent aberrant recombination by excluding Rad51, while promoting the mobilization of repair sites through immiscibility with heterochromatin protein 1 (HP1) condensates.

dlvr.it

altmeyerlab @altmeyerlab.bsky.social · last yr.

Looking very much forward to the 2nd edition of the Fusion Conference on Spatial Genome Organisation #SGO25 @fusionconf.bsky.social @karimmekhail.bsky.social @chiololab.bsky.social. Early bird registration closes soon: June 2nd, 2025. Slots available for selected talks from abstracts: bit.ly/4492G6i

2nd Spatial Genome Organisation Conference | Fusion Conferences

Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...

fusion-conferences.com

Effie Apostolou lab @efapostolou29.bsky.social · 2y ago

The first cancer-related story from our group @WeillCornell is now published in @MolecularCell. We investigate the role of hyperconnected 3D regulatory hubs in controlling oncogenic programs and properties in glioblastoma and also across 16 cancer types. www.cell.com/molecular-ce...

Three-dimensional regulatory hubs support oncogenic programs in glioblastoma

Here, Breves et al. profile the 3D enhancer-promoter connectomes of patient-derived glioblastoma stem cells (GSCs), identify hyperconnected 3D regulatory “hubs” relevant for GBM biology, examine the i...

cell.com

University of Toronto @utoronto.ca · 2y ago

Melanie Woodin, an internationally recognized neuroscientist who studies the mechanisms underlying learning and memory in the brain, has been named #UofT’s 17th president. ➡️ uoft.me/uoftpres

Ellenberg Lab @ellenberglab.bsky.social · 2y ago

Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social! Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩 www.sciencedirect.com/science/arti...

Nanoscale DNA tracing reveals the self-organization mechanism of mitotic chromosomes

How genomic DNA is folded during cell division to form the characteristic rod-shaped mitotic chromosomes essential for faithful genome inheritance is …

sciencedirect.com

EMBL@embl.org · 2y ago

Did you know that DNA must form overlapping loops to give rise to the well-known X-shape of chromosomes? 🧬🧪 New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation. @ellenberglab.bsky.social @andibrunner.bsky.social www.embl.org/news/science...

Tyler Weaver @tmweaver.bsky.social · 2y ago

The final piece of my postdoctoral work in the @freudlab.bsky.social was recently published! Quite amazing what this small little repair polymerase can do to fill 1-nt gaps in chromatin. www.nature.com/articles/s41...

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 2y ago

This RNA modification drives prostate cancer progression Our recent study reveals that m6A RNA modification promotes prostate tumour growth and relapse. Specifically, it boosts the production of a cell movement molecule to aid cancer metastasis. www.nature.com/articles/s41...

Pagès lab @pageslab.bsky.social · 2y ago

Our latest article, in collaboration with Helle Ulrich, explores how the timing of lesion bypass and gap processing impacts genome stability. doi.org/10.1093/nar/...

Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 2y ago

Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance www.cell.com/cancer-cell/...

Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance

Recent research highlights horizontal mitochondrial transfer as a key biological phenomenon linked to cancer onset and progression. The transfer of mitochondria and their genomes between cancer and no...

cell.com

Mekhail Lab at U. Toronto 🍁🇨🇦@karimmekhail.bsky.social · 2y ago

🚨 Excited to announce the 2nd Spatial Genome Organisation Conference! #SGO25 📅 Oct 31–Nov 3, 2025 | 📍 Riviera Maya, Mexico 🪑 Chairs: @altmeyerlab.bsky.social, @chiololab.bsky.social, @karimmekhail.bsky.social 🔗 Registration: fusion-conferences.com/conference/188 Please 🔄 ❤️

University of Toronto @utoronto.ca · 2y ago

The source code for AlexNet – the neural network developed at #UofT that kickstarted today’s AI boom & led to a Nobel Prize – will be preserved by the Computer History Museum in partnership with Google. 💻 uoft.me/bqR

Geoffrey Hinton, right, with graduate students Ilya Sutskever, left, and Alex Krizhevsky, middle

Eric Topol @erictopol.bsky.social · 2y ago

I've reviewed 10 consumer-facing companies that are in the business of promoting longevity and healthspan erictopol.substack.com/p/the-busine... Open-access, in the new edition of Ground Truths

Table of 10 companies selling longevity and extended healthspan

Manuel Mendoza @longchrom.bsky.social · 2y ago

Come start your lab in beautiful Strasbourg 🇫🇷 www.nature.com/naturecareer...

Call For Two Group Leader Positions - Strasbourg-Ville, Bas-Rhin (FR) job with IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) | 12837602

The Institute of Genetics, Molecular and Cellular Biology (IGBMC) is seeking two outstanding group leaders to establish independent research teams.

nature.com

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 2y ago

Why AI won’t replace scientists capable of making disruptive conceptual breakthroughs - they pose questions that challenge, rather than align with, the training data set thomwolf.io/blog/scienti...

🔭 The Einstein AI model

I shared a controversial take the other day at an event and I decided to write it down in a longer format: I’m afraid AI won't give us a compressed 21st century.

thomwolf.io

Mekhail Lab at U. Toronto 🍁🇨🇦@karimmekhail.bsky.social · 2y ago

As relevant today as ever: “An eye for an eye only ends up making the whole world blind.” Mahatma Gandhi

Kazuhiro Maeshima @kazu-maeshima.bsky.social · 2y ago

A unified model for cohesin function in sisterchromatid cohesion and chromatin loop formation: Molecular Cell www.cell.com/molecular-ce...

A unified model for cohesin function in sisterchromatid cohesion and chromatin loop formation

Structural maintenance of chromosomes (SMC) complexes are thought to shape genomes by extruding DNA loops, but recent genetic tests have challenged the “loop extrusion hypothesis.” Here, Uhlmann explo...

cell.com

Manuel Mendoza @longchrom.bsky.social · 2y ago

Almost 17 years after opening our yeast cell division lab, our first transcription paper in mouse embryonic stem cells! www.science.org/doi/10.1126/...

This schematic illustrates the interplay between transcription coactivator perturbations (e.g., TIP60 or ATAC complex depletion) and RNA homeostasis. Perturbations lead to alterations in mRNA synthesis, which are counterbalanced by changes in mRNA export and cytoplasmic decay of specific transcripts, thereby maintaining RNA homeostasis.

Mekhail Lab at U. Toronto 🍁🇨🇦@karimmekhail.bsky.social · 2y ago

🚀 New Paper Alert! Our latest @natrevmcb.bsky.social explores how nuclear and genome organization drive DNA double-strand break repair! 🧬 📖 Free access: rdcu.be/edViW Please 🔄 ❤️

Nuclear and genome dynamics underlying DNA double-strand break repair

Nature Reviews Molecular Cell Biology - Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the...

rdcu.be

Tony Cesare @thecesarelab.bsky.social · 2y ago

1/Out today in @naturecomms.bsky.social, “A CPC-shelterin-BTR axis regulates mitotic telomere deprotection”. Here we identify the mechanism that unwinds telomere-loops (t-loops) during mitotic arrest to activate the DNA damage response and signal mitotic stress. www.nature.com/articles/s41....

A CPC-shelterin-BTR axis regulates mitotic telomere deprotection - Nature Communications

Here the authors reveal how telomeres signal mitotic stress. A key protein network alters their structure exposing telomere ends to signal mitotic stress, ultimately triggering a controlled DNA damage...

nature.com