How do dendritic cells control tertiary lymphoid structures in cancer? Raphaël Mattiuz just showed us how–just out in @science.org Happy I could contribute to this important piece. @miriammerad.bsky.social www.science.org/doi/10.1126/...

Dendritic cells control tertiary lymphoid structure development and maintenance in cancer

Tertiary lymphoid structures (TLSs) are associated with immunotherapy response, yet the mechanisms controlling their formation and maintenance remain unclear. Using spatial transcriptomics and multipl...

science.org

Our paper out in Science today: The Metis defense system senses molecular byproducts released when a phage degrades the bacterial genome, and then prevents replication of the phage in the infected cell Congratulations @ostermanilya.bsky.social and co-authors!

Bacteria sense virus-induced genome degradation via methylated mononucleotides

Phages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...

science.org

Osterman Ilya@ostermanilya.bsky.social · 2mo ago

Excited to share that our Metis story is now published in Science! 🎉 Bacteria can sense phage-induced degradation of their genome and activate immunity. Many thanks to everyone who contributed to this work. 📄 www.science.org/doi/10.1126/... More details in my earlier thread 🧵⬇️

Congrats Moshe, Sasha and team! @weizmann . Glad to see this out! A beautiful story showing how epithelial stem cells differentiate upon salmonella infection to adapt the tissue while maintaining the stem cells pool intact 👇🏻 www.nature.com/articles/s41...

An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella infection - Nature Immunology

Salmonella-invaded intestinal stem cells activate an inflammasome-driven differentiation program toward antimicrobial Paneth cells, revealing a protective stem cell defense mechanism that helps restri...

nature.com

To strengthen the European research on early life immunology we have started the EFIS study ELINE Info and seminar announcement 👇🏼 #EFIS#ELINE#immunology

Early-life Immune Network Europe@efis-eline.bsky.social · 7mo ago

We are excited to kick-off of our seminar series on March 5, 4pm CET 🥳 🎤 Petter Brodin – A seeding reaction to colonizing microbes in human newborns 🎤 Eva Stange – Neonatal liver niches program T cell tolerance Register here: www.efis-eline.eu/seminars #EarlyLifeImmunity #Immunology #EFIS

Looking for motivated postdocs interested in doing exciting research at the intersection of immunology and regenerative biology. We use intravital two-photon imaging to track and manipulate immune cell behavior at the single-cell level in live animals mesa-lab.org Apply: apply.interfolio.com/180660

Mesa Laboratory

mesa-lab.org

Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/ www.nature.com/articles/s41...

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology

Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...

nature.com

Very happy to share our new study defining the ontogeny of Thetis cells and the developmental cues that shape their early-life wave of differentiation. www.nature.com/articles/s41... Beautiful work led by @hhmi-science.bsky.social Gilliam Fellow Yoselin Paucar Iza and postdoc Tyler Park 1/

Registration is open! @weizmanninstitute.bsky.social erez.weizmann.ac.il/apx/r/ws1/10...

As 2025 is drawing to a close, @jem.org would like to highlight all of the women who have contributed to the #WomenInSTEM #Viewpoint series over the last 3 years! Learn more about their scientific journeys on the path to independence here 👉 tinyurl.com/2wrxk4mk

Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy. www.nature.com/articles/s41... www.nature.com/articles/s41... @mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social

Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology

Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.

nature.com

Another excellent #Viewpoint! Thank you to our contributors @priyadevarajan.bsky.social, @rzappasodi.bsky.social, Novalia Pishesha, Jui-Hsia Weng, Kate Alexander, Yadira Soto-Feliciano, and @kedmiranit.bsky.social ✨

Journal of Experimental Medicine@jem.org · 11mo ago

Latest in our #WomenInSTEM series from researchers discussing their science and the process of setting up a lab as an independent researcher, as well as the unique challenges they face as women scientists in their respective scientific environments: rupress.org/jem/article/...

Latest in our #WomenInSTEM series from researchers discussing their science and the process of setting up a lab as an independent researcher, as well as the unique challenges they face as women scientists in their respective scientific environments: rupress.org/jem/article/...

👇🏻👇🏻

Chrysothemis Brown@chrysothemisbrown.bsky.social · 11mo ago

Excited to share our review on Thetis cells and dendritic cells, and their roles in mucosal immunity and tolerance @natimmunol.nature.com rdcu.be/eLtB1

Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here: www.biorxiv.org/content/10.1...

Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells

Tissue-resident memory CD4+ T cells (TRM) are key sentinels of the adaptive immune response that provide a rapid, robust inflammatory response upon reactivation in non-lymphoid tissues. While CD4+ TRM...

biorxiv.org

Nice!

Seth Thomas Scanlon@immunoeditor.bsky.social · 11mo ago

To celebrate this year’s #NobelPrize in #Medicine, awarded for the discovery of regulatory #TCells, we have selected 8 papers recently published in #Science #Immunology that highlight recent advances in #Treg biology! The collection will be online until the end of Oct 2025! bit.ly/SciImm_free

Simply wonderful!

Science News@scinews.bsky.social · 11mo ago

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

“If you look back at the data, 250 years ago, 40% of kids never made it to adulthood. Today, it’s 4%. The majority of that decrease is due to vaccines. Vaccines have saved more lives than any other type of medical intervention, including antibiotics... -Dr. Drew Weissman, Nobel Laureate.

Simply wonderful!

Adrian Liston@labliston.bsky.social · 12mo ago

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

x.com/shouval/stat...

Ruth Shouval on X: "For the full text of the statement in English and Hebrew: https://t.co/bwk7HLRN49" / X

For the full text of the statement in English and Hebrew: https://t.co/bwk7HLRN49

x.com

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com www.nature.com/articles/s41... This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social Thread below...

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology

Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...

nature.com

I wish I could be there! Our amazing @annarudnitsky.bsky.social will give a talk on Friday — don’t miss it! www.nature.com/articles/s41...

Mauro Gaya@maurogaya.bsky.social · 2y ago

🇨🇭🔆 Join us this summer in Basel to discuss the latest discoveries in B cells, T cells and mucosal immunology! 🦠🫁🧠💩. 🪁🚂 Childcare support & travel grants available. 🌎 Plus, special bursaries for attendees from Chile, India, Singapore, and Taiwan. 📢 Help us spread the word! #EMBOBarrierTissues

The #IUIS2025 was way above my expectations! It was so great to meet old and new friends and to share our work. @iuis-online.bsky.social

It was mind blowing

Caetano Reis e Sousa@reisesousalab.bsky.social · last yr.

Great keynote lecture by Ruslan Medzhitov on how the “educated” immune system of pet shop mice allows them to resist experimental allergic sensitisation. Thought provoking, as usual. #IUIS2025.

Great keynote lecture by Ruslan Medzhitov on how the “educated” immune system of pet shop mice allows them to resist experimental allergic sensitisation. Thought provoking, as usual. #IUIS2025.

Some pics from the #RisingStars Day 2! Don't forget to share — which sessions have you liked the most so far? #ImmunologyWithoutBorders

Meet Dr @KedmiRanit, PI at Weizmann Institute. Her research reveals how immune cells coordinate to shape T cell responses. At #IUIS2025, she’ll present “A coordinated cellular network regulates intestinal tolerance.” 🔬🌍 https://loom.ly/CwagY2g #RisingStars2025 #RoadtoVienna

Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity, says Alon Chen https://go.nature.com/40wXMx6

How we’re rebuilding the Weizmann Institute — and our hopes for a better future

Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity.

go.nature.com

Thanks for choosing me! See you there 🌟

International Union of Immunological Societies@iuis-online.bsky.social · last yr.

IUIS and its Early Career Committee are thrilled to announce the IUIS #RisingStars2025 Cohort! 🌟 https://loom.ly/f5Gq1f8 Fifteen exceptional early-career scientists from across the globe to join our #RisingStars Program Don’t miss your chance to meet them https://loom.ly/CwagY2g

Free/public access: rdcu.be/enZTa

Ranit Kedmi@kedmiranit.bsky.social · last yr.

Incredible! Over the past 2 months, 5 independent manuscripts — from @TheColonnaLab, Dan Littman, @gardnerlabucsf.bsky.social and @chrysothemisbrown.bsky.social , and our own (now in @nature.com, www.nature.com/articles/s41...), reports that the dietary pTreg program is initiated by RORγt⁺ APCs. /1

'However, we now report that food-specific pTreg cells are exclusively induced by the recently identified RORγt APCs4–8 and not by cDCs. Instead, our data suggest that pTreg–cDC1 interactions in steady-state limit the expansion of food-specific CD8αβ T cells.' www.nature.com/articles/s41...