Keren Lasker
@kerenlasker.bsky.social
Membraneless Organelles in Bacteria: Structure, Dynamics, Function, and Engineering. Assistant Professor @scripps.edu. https://laskerlab.org/
Want to organize a Minisymposium, Workshop, or Special Interest Subgroup? Now’s your chance to lead at Cell Bio 2026. 🗓 Scientific session proposals due February 22 https://www.ascb.org/cellbio2026/
Cell Bio 2023-An ASCB|EMBO Meeting
Network, learn, and collaborate with top cell biologists from around the globe.
ascb.org
Thrilled to share our latest work--combining CATCH with whole-body HYBRiD imaging, leveraging click chemistry to visualize and identify drug-targeted cells across organ systems. Led by a brilliant team: former PhD student Ben Pang and former undergrad Verina Leung.
Cell - a Cell Press journal@cp-cell.bsky.social · 10mo agoNow online! Mapping cellular targets of covalent cancer drugs in the entire mammalian body
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...
An integrated view of the structure and function of the human 4D nucleome - Nature
The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...
nature.com
Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
bioRxivpreprint@biorxivpreprint.bsky.social · 10mo agoOrganelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
The @biophysicalsoc.bsky.social IDP Subgroup Postdoctoral Award honors outstanding Postdoctoral Fellows for research accomplishments with disordered proteins. APPLY by sending your nomination packet to idpsubgroupbps@gmail.com by Dec 15th! Info at: www.biophysics.org/awards-fundi...
Subgroup Awards - The Biophysical Society
biophysics.org
Congratulations to Lucy Shapiro, 2025 #LaskerAward winner! – “for a 55-year career in biomedical science – honored for discovering how bacteria generate distinct daughter cells; and for exemplary leadership at the national level” #Lasker2025 #LaskerLaureate #devbio 🧪
Over the moon to see my postdoc advisor, Prof. Lucy Shapiro, receive a Lasker Award—a brilliant salute to her decades of trail-blazing science, visionary leadership, and transformative mentorship. Congratulations!
Albert and Mary Lasker Foundation@laskerfdn.bsky.social · last yr.Congratulations to this year’s #LaskerAward winners! Basic: Dirk Görlich & Steven L. McKnight Clinical: Michael J. Welsh, Jesús (Tito) González, & Paul A. Negulescu Special Achievement: Lucy Shapiro Laskerfoundation.org #Lasker2025 #LaskerLaureate
Join us this Thursday, June 12, at 1PM for the first of our three summer virtual masterclasses — where seasoned PIs share how they transformed foundational science into VC-backed startups. 🔬🌟 🎟️ For more info, contact biotechsummit@scripps.edu.
🎉 Congratulations to Wolfgang Baumeister @maxplanck.de, awarded the 2025 #ShawPrize in Life Science & Medicine for pioneering work in cryo-ET! Learn more 👉 europa.eu/!JBXDBG #FrontierResearch #ERCSyG #CryoET #StructuralBiology #shawprize2025
ERC grantee wins the Shaw Prize in Life Science and Medicine
2025 Shaw Prize honours ERC-funded research in molecular imaging
europa.eu
Now published! Big congrats to first author @gginell.bsky.social We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions. www.science.org/doi/10.1126/...
Sequence-based prediction of intermolecular interactions driven by disordered regions
Intrinsically disordered regions (IDRs) in proteins play essential roles in cellular function. A growing body of work has shown that IDRs often interact with partners in a manner that does not depend ...
science.org
Alex Holehouse@alexholehouse.bsky.social · 2y agoExcited to share new work from Garrett Ginell et al where we present an approach for predicting intermolecular interaction driven by disordered regions. We focus on how chemical complementarity can contribute to and even dictate intermolecular interactions www.biorxiv.org/content/10.1...
In collaboration with the @lindorfflarsen.bsky.social group we release our map of degrons in >5,000 human cytosolic proteins with >99% coverage. A machine learning model trained on the data identifies missense variants forming degrons in exposed & disordered regions. Work led by @vvouts.bsky.social.
A complete map of human cytosolic degrons and their relevance for disease
Degrons are short protein segments that target proteins for degradation via the ubiquitin-proteasome system and thus ensure timely removal of signaling proteins and clearance of misfolded proteins fro...
biorxiv.org
AlphaFold is amazing but gives you static structures 🧊 In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃 Code: github.com/KULL-Centre/... Colab: github.com/matteo-cagia...
bioRxiv Biophysics@biorxiv-biophys.bsky.social · last yr.AF2χ: Predicting protein side-chain rotamer distributions with AlphaFold2 https://www.biorxiv.org/content/10.1101/2025.04.16.649219v1
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
science.org
Announcing the joint @idpseminars.bsky.social / BPS IDP Subgroup Trainee Symposium Speakers! Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now using the QR code below!
This summer in beautiful Santa Barbara we will run a 3-day conference on “Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment” June 16 to 18th. Register now: www.kitp.ucsb.edu/activities/b...
Big health breakthrough: a protein from tardigrades can now protect human cells from radiation. That’s going to lead to better cancer therapies.
Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades - Nature Biomedical Engineering
Radiation-therapy-induced DNA damage in oral and rectal epithelial cells can be reduced via the nanoparticle-mediated local delivery of messenger RNA encoding for a damage-suppressor protein found in ...
nature.com
New Preprint ‼️ Work led by the incredible @ananyac2000.bsky.social 💃🏽💃🏽 Mpipi-T is finally here!!! 🥳🥳 👇🏽👇🏽 www.biorxiv.org/content/10.1...
Accurate prediction of thermoresponsive phase behavior of disordered proteins
Protein responses to environmental stress, particularly temperature fluctuations, have long been a subject of investigation, with a focus on how proteins maintain homeostasis and exhibit thermorespons...
biorxiv.org
Ananya Chakravarti@ananyac2000.bsky.social · 2y agoCells have evolved to adapt to changing environments to maintain homeostasis. Can we predict how temperature affects protein phase separation? 🌡️ (1/4)
MBoC #CallForPapers: Special Issue on Biomolecular Condensates Submit to be considered by lead editors: Amy Gladfelter, University of North Carolina Jeffrey B. Woodruff, UT Southwestern Medical Center Huaiying Zhang, Carnegie Mellon University www.molbiolcell.org/biomolecular... #CellBiology
From MBoC AI: A transformative opportunity in cell biology, by Sandra Schmid, Chan Zuckerberg Biohub Network, et al. doi.org/10.1091/mbc.... #CellBiology
AI: A transformative opportunity in cell biology | Molecular Biology of the Cell
The success of artificial intelligence (AI) algorithms in predicting protein structure and more recently, protein interactions, demonstrates the power and potential of machine learning and AI for adva...
doi.org
www.biorxiv.org/content/10.1...
Molecular grammars of intrinsically disordered regions that span the human proteome
Intrinsically disordered regions (IDRs) of proteins are defined by functionally relevant molecular grammars. This refers to IDR-specific non-random amino acid compositions and non-random patterning of...
biorxiv.org
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA. Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.
cell.com
First senior-author paper is out today in the Journal of Microscopy! 🧪🔬 We present the first 3D printed microscope where both the optics & frame are entirely 3D printed - a low-cost, accessible, and reproducible tool for histological imaging! onlinelibrary.wiley.com/doi/full/10.1111/jmi.13398
In a new op-ed for the @sandiegouniontribune.com, Scripps Research President and CEO Pete Schultz discusses how proposed changes to federal science funding could have unintended consequences for biomedical research, innovation, and the broader life sciences ecosystem in San Diego.
Opinion: Science funding cuts are based on flawed logic. Here’s the truth.
Earlier this month, the National Institutes of Health issued supplemental guidance indicating it would immediately impose a 15% cap on indirect costs for research grants, an unprecedented and abrup…
sandiegouniontribune.com
Ever wondered how mammalian cells sense osmotic stress? There's gotta be a signaling pathway, right? We propose a *one-component system*: NFAT5, the transcription factor that executes the osmoprotective response, is also the stress sensor! www.science.org/doi/full/10....
Direct ionic stress sensing and mitigation by the transcription factor NFAT5
Intracellular ionic strength is sensed and regulated by a prion-like domain in a transcription factor.
science.org
🎉🎉 Kudos to @bornanovak.bsky.social , Jeff, Ryan, and @alexholehouse.bsky.social —this breakthrough work paves the way for exciting new frontiers in disordered protein research! 🌟✨
Borna Novak@bornanovak.bsky.social · 2y agoExcited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models). www.biorxiv.org/content/10.1...
Part I of BIV subgroup starts in an hour (8:30 am PT) Join us!
Keren Lasker@kerenlasker.bsky.social · 2y ago🚀 Join us at #BPS2025 tomorrow at 8:30 AM for a spectacular lineup of cutting-edge methods & biology in Biopolymers In Vivo! 🧪🔬 🧠 AI & IDP phase behavior | 🌱 Protein thermosensing | ❄️ Cryo-EM 🧬 GTPase activity | 🛠️ Engineered condensates | 🤖 Deep learning | 💧 Phase separation
🚀 Join us at #BPS2025 tomorrow at 8:30 AM for a spectacular lineup of cutting-edge methods & biology in Biopolymers In Vivo! 🧪🔬 🧠 AI & IDP phase behavior | 🌱 Protein thermosensing | ❄️ Cryo-EM 🧬 GTPase activity | 🛠️ Engineered condensates | 🤖 Deep learning | 💧 Phase separation
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
🎉🧪New perspective paper! Single-point missense mutations are common in disordered regions but are often overlooked👀. We analyzed thousands of IDR point mutations associated with human congenital diseases to show that many can significantly change local IDR ensemble structure! shorturl.at/iIbLX
