Levi Todd

@levi-todd.bsky.social

Asst prof @ SUNY Upstate trying to regrow neurons Toddlab.org

First paper entirely from our lab is out in the wild! We tested if reprogramming still works in the aged CNS and found the aged retina blocks neurogenesis both intrinsically in Müller glia and through exacerbated inflammation. Then point at some ways to overcome this. www.pnas.org/doi/10.1073/...

Aging limits neuronal regeneration from glia in the mouse retina | PNAS

Reprogramming resident glia into neurons holds great therapeutic promise for neurodegenerative diseases across the central nervous system, yet thes...

pnas.org

I’m excited to share the newest publication from the lab where we charactize the zebrafish Atoh7 retinal lineage in wild type and Atoh7 mutants, discover an Atoh7 negative RGC population, and find lineage positive cells in the CNS outside of the optic tectum. iovs.arvojournals.org/article.aspx...

Lineage Tracing Reveals atoh7-Positive and Negative Retinal Ganglion Cell Populations in the Zebrafish Retina | IOVS | ARVO Journals

iovs.arvojournals.org

Preprint for the first manuscript of the Angueyra Lab is out! We delve deep into cell-fate decisions during photoreceptor development and discover that the 𝘵𝘣𝘹2 paralogues play multiple roles to control the fate of the five photoreceptor subtypes in zebrafish.

bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · 2mo ago

Transcriptional regulation by Tbx2 paralogs creates diversity within photoreceptor subtypes https://www.biorxiv.org/content/10.64898/2026.07.20.739565v1

Our new paper is out! 🎉 Let-7 doesn’t act through a single pathway: it controls neocortical neuron fate and migration via distinct downstream mechanisms, with RBX2 dedicated to migration. A new layer of post-transcriptional control shaping cortical development www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

pnas.org

“The atoh7:iCre;ubi:Switch transgene combination successfully recapitulated the onset of endogenous atoh7 expression… We determined 79% of total RGCs in the wild type retina come from atoh7+ progenitor cells, a greater number than reported in the mouse retina” New from @joelmiesfeld.bsky.social 🐟

bioRxivpreprint@biorxivpreprint.bsky.social · 6mo ago

Lineage tracing reveals atoh7 positive and negative retinal ganglion cell populations in the zebrafish retina https://www.biorxiv.org/content/10.64898/2026.03.19.712911v1

Resident tissue #macrophages (RTM) are now recognized as integral regulators of tissue physiology, not transient immune sentinels. one fundamental question remains unresolved: why do some populations achieve lifelong self-maintenance, while others are replaced under steady-state conditions? 🧵1/11

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The 2026 Visual System Development GRC and GRS are fast approaching. Jeremy Kay, Kristen Kwan, Robert Johnston, and I have built an exciting program that we hope you will enjoy. Looking forward to seeing everyone at the meeting this summer in beautiful Maine. Register and RT!

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I'm excited to share our PNAS paper from 1st author Kasia Hussey. We study how the foveola, the high acuity region of the retina, is patterned by RA and TH. We were surprised to find that cone subtypes appear to convert fates. Our studies are important for AMD sufferers. www.pnas.org/doi/10.1073/...

A cell fate specification and transition mechanism for human foveolar cone subtype patterning | PNAS

In the central region of the human retina, the high-acuity foveola is notable for its dense packing of green (M) and red (L) cones and absence of b...

pnas.org

Happy to announce that our latest paper is now out! Have you ever wondered how neural tissues control their size? In this paper, we show that cell division orientation is critical in both the cortex and retina. www.science.org/doi/10.1126/...

Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species

A fundamental role for division orientation in progenitor output driving cortical and retinal growth is revealed.

science.org