Immune cells target hyperactive neurons to eliminate synaptic connections @science.org @soyonhonglab.bsky.social @ucl.ac.uk www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

"Right now, in some underfunded lab, a scientist is chasing a question that sounds pointless...a century of experience says that funding people to do this work is a good bet. If we stop making that bet, we will pay for it in cures no one will know to miss."

Victor Ambros@vambros.bsky.social · 2mo ago

A column by Jeff Coller: “The Science That Turned Lizard Venom Into GLP-1s Is Under Attack” www.nytimes.com/2026/06/20/o...

One of the world's leading brain research centers is shifting away from fruit flies and toward a tiny, transparent fish. The goal: to understand how brains control the behavior of an animal or human. n.pr/4vV8dYM

Is a transparent fish the future of brain science? This center is betting on it

One of the world's leading brain research centers is shifting away from fruit flies and toward a tiny, transparent fish. The goal: to understand how brains control the behavior of an animal or human.

n.pr

Animal models continue to be critical to our understanding of complex biological and medical concepts. To learn more about the ethics and safeguards in place for responsible animal research, read this open-access article on the topic: www.nature.com/articles/s41...

NPR@npr.org · 2mo ago

One of the world's leading brain research centers is shifting away from fruit flies and toward a tiny, transparent fish. The goal: to understand how brains control the behavior of an animal or human. n.pr/4vV8dYM

It’s Pride 🏳️‍🌈 Spare one repost for a small creator? 🥺 My science and sci fi pins raise money for homeless LGBTQ+ people. Just sent another £800 to @aktcharity.bsky.social bringing total to £47,521 New for Pride 2026: 🌈Scientist🌈 🏳️‍🌈🐥🦜🦅🏳️‍🌈 🌈pronouns🌈 www.jamiebgall.co.uk/shop

NEW PROFILE PIC ✨ Happy #PrideMonth, shoalmates! Our avatar Danny-O is rockin' their favorite guitar throughout the month 🤘🏳️‍🌈 #RockOn 🧪

🪼 Your tax dollars paid a scientist to squeeze jellyfish through cheesecloth. Osamu Shimomura processed tens of thousands on an NSF grant to understand why they glow. He found a protein that glowed green under UV light. Called it "green protein." Nobody cared. For decades.

Pioneer work from the Frank Kooy lab published today in The Lancet eBioMedicine. Congratulations to Claudio D’Incal and all co-authors. Proud to have contributed to this study on ADNP-related neurodevelopmental mechanisms and Wnt signalling. www.thelancet.com/journals/ebi...

An Adnp frameshift variant disrupts Wnt signalling inducing chromatocytoskeletal defects and autism-related behaviour in male mice

We generated a disease-relevant heterozygous Adnp mouse model that recapitulates key molecular and behavioural features observed in patients with Helsmoortel-Van der Aa syndrome. Our findings demonstr...

thelancet.com

The Hoffman Lab at Yale is hiring! We’re currently recruiting for a Lab Manager and Post-Graduate Research Associate positions. If you're interested in understanding the function of neurodevelopmental disorder genes in the developing brain using #zebrafish, we'd love to hear from you! #researchjobs

⏰ Reminder: the abstract submission deadline for the Network Glia Satellite Event at FENS 2026 is today, 30 April! SE07 – Emerging roles of glial cells in brain function and disease 📍 Barcelona 📅 5 July 2026

ATgliaNet@atglianet.bsky.social · 5mo ago

European Glial Meeting | Network Glia and the National and Regional Glia Networks, including ATgliaNet, organize the first joint Satellite Event at Federation of European Neuroscience Societies - FENS Forum in Barcelona. Date: 5.7.2026, 9:00 – 18:00 More information: lnkd.in/eMCMAX56

My paper is finally out in @natcomms.nature.com ! 🐟🐭🧠 Thankful to the contributors and @annamolofskylab.bsky.social for the support! How does the developing brain clear millions of dying neurons? Read below, if interested. #zebrafish #neuroscience #microglia #devbio @zebrafishrock.bsky.social 1/5

Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!

Astrocytes connect specific brain regions through plastic networks - Nature

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

nature.com

Lovely highlight of a new fascinating study by @ehoffmanlab.bsky.social 🐟💊 For those interested, 🔗 to original research: www.pnas.org/doi/10.1073/...

The Transmitter @thetransmitter.bsky.social · 4mo ago

Nearly 400 compounds displayed significant effects on at least two behavioral parameters in zebrafish with SCN2A or DYRK1A variants, according to a new study. By Charles Q. Choi www.thetransmitter.org/animal-model...

Happy to share our new paper published in Nature Communications! www.nature.com/articles/s41... We developed CaMPARI-seq to link neural activity with molecular profiles and revealed how the brain distinguishes optic flow to guide behavior. Congratulations to our postdoc Koji Matsuda!

Molecular and functional dissection using CaMPARI-seq reveals the neuronal organization for dissociating optic flow-dependent behaviors

Nature Communications - In this study, the authors develop CaMPARI-seq to link neural activity with molecular profiles in larval zebrafish. They identify inhibitory pretectal neurons required for...

rdcu.be

🚨 Turning on heart regeneration through immune modulation? Led by @kcinc.bsky.social, we show that activating pro-regenerative macrophages induces Granulin, a key driver of cardiomyocyte proliferation and scar resolution in medaka, now published in @pnas.org 💔➡️❤️ www.pnas.org/doi/10.1073/...

Immune modulation promotes heart regeneration through macrophage and Granulin functions in medaka | PNAS

Myocardial infarction results in irreversible cardiomyocyte loss and fibrotic remodeling in adult mammals, whereas some vertebrates retain the abil...

pnas.org

New work from @ehoffmanlab.bsky.social 🐟 🔗 to original research: www.pnas.org/doi/10.1073/...

Pharmaco-behavioral profiling identifies suppressors of autism gene–associated phenotypes in zebrafish | PNAS

Pharmaco-behavioral screens in scalable in vivo systems have critical advantages for drug discovery relevant to large-effect autism spectrum disord...

pnas.org

hellen-cwm.bsky.social@hellen-cwm.bsky.social · 4mo ago

Congratulations to all of us involved in this large-scale profiling of drugs relevant to ASD genes ! There’s so much the zebrafish have and will continue to inform us about !!

I created this collection of common brain models in neuroscience, all to scale Across species, brains share fundamental principles and many homologous regions But as size increases, complexity and connectivity change. We need the full spectrum, from flies to rodents, non-human primates, and humans

Very happy to share this study from our group and colleagues now out in Science! We found that in zebrafish, before the immune system is mature, gut epithelial cells perform immune functions by producing the cytokine IL-22 to shape the microbiota to promote early life gut function #Zebrafish #Gut

IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota

The gut microbiota, immune system, and enteric nervous system interact to regulate adult gut physiology. However, the mechanisms establishing gut physiology during development remain unknown. We repor...

science.org

A transcriptomic microglia taxonomy across mouse and human pathologies www.nature.com/articles/s41...

I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

“Here we present ZMAP (Zebrafish Meta Atlas Project), a harmonized reference integrating 8 published whole-embryo zebrafish scRNA-seq datasets comprising 798,790 cells across 15 developmental time windows.” 🐟 🧪 New work from @danwagnerlab.bsky.social 🔗 to WebApp: wagnerlabucsf.github.io/zmap/

bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · 4mo ago

ZMAP: A single-cell meta-atlas of zebrafish embryonic development reveals a consensus hierarchy of cell identities https://www.biorxiv.org/content/10.64898/2026.03.23.713599v1

It's #GatorGivingDay and we're almost at our goal! Every $$ supports our wonderful students and community here at @sfstatebio.bsky.social Thank you for your support! giving.sfsu.edu/schools/SanF...

Department of Biology

Join me and make a gift to Gator Giving Day 2026

giving.sfsu.edu

Undergraduate student Alexandra Jose shares “SFSU has provided me with such amazing opportunities to let me pursue my academic goals, contribute to research that inspires me, and be part of an incredible community!” Your gift makes such research opportunities possible. #GatorsGiveDay

“Here, we combined inducible lineage tracing, single-cell RNA sequencing and morphological analysis to define the molecular and structural features of Muller glia derived neurons in the adult zebrafish retina [following injury]” New work from Thanh Hoang et al. at University of Michigan 🐟 👁️

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 5mo ago

Muller glia mediated regeneration restores neuronal diversity and retinal circuit organization in the adult zebrafish https://www.biorxiv.org/content/10.64898/2026.03.15.711785v1

New paper from @uwe689.bsky.social ! Muscle and #ECM remodeling during fly metamorphosis is still poorly understood. Why? Pupae are really hard to work with. Uwe took on the challenge and explored how Mmp2 contributes to this amazing morphogenetic process. www.nature.com/articles/s41... #cellbio

Youthful antics predict lifespan? Using machine learning & continuous recordings of #killifish behavior from adolescence until death, @brunetlab.bsky.social & @deisseroth.bsky.social find early-life behavior predicted future lifespan! Now published @science.org: www.science.org/doi/10.1126/... 🧪 1/2

Super stoked to share that I’m starting my lab at UHN @dkjei-uhn.bsky.social / @kbi-uhn.bsky.social and the University of Toronto! If you’re interested in neuron-myelin interactions in circuit maturation and cognition, please reach out - we are hiring! www.oligodendrocyte.org 1/

Xin Lab

Welcome! We study the cellular interactions between neurons and oligodendrocytes, which produce myelin in the central nervous system. Myelination - the process by which oligodendrocytes ensheath neuro...

oligodendrocyte.org

Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties. @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Excited to share our new study using engineered immune proteins to quench inflammation in aged brains!! Congratulations to Paloma Navarro and the entire team! Fantastic collaboration with Chris Garcia's lab, Tony Wyss-Coray's lab, and Saul Villeda's lab! www.cell.com/immunity/ful...

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition

Immune cells populate the old brain, but whether they can be specifically targeted to improve brain function in older individuals remains unclear. Navarro Negredo et al. dissect how aging impacts brai...

cell.com