Dysregulated MUC5B and MUC5AC impair epithelial barrier function and alter granulocyte frequency and activation in the lung and distal sites www.mucosalimmunology.org/article/S193...
Madison (Maddi) Strine
@madison-strine.bsky.social
Yale Science Fellow studying human early life T cell-epithelial crosstalk in the lab of Dr. Liza Konnikova | Tuft cell enthusiast | PhD Yale Immunobiology ‘23 | Gettysburg College ‘18 | she/her
A 3D multi-compartment assembloid to study combined immune cell infiltration and cytotoxicity Contains different compartments with different ECM. Especially useful to test infiltration and cytotoxicity of CAR T cell therapies. More here: www.cell.com/cell-reports...
Force generated by blood flow in developing embryos dictates a bioenergetic switch (increased mTORC1 & mitochondrial genes) necessary for hematopoietic stem cell emergence @jem.org @uthealthhouston.bsky.social rupress.org/jem/article/...
We are hiring! We have a postdoc position opened @fredhutch.org to join our team to design next gen cellular therapies for cancer. Heavy focus on T cell signaling and understanding how synthetic receptors instruct T cells to fight cancer.
"In the face of these challenges, I felt more strongly than ever that I should help open doors for others." In this #ScienceWorkingLife, Edgar Virguez writes about working to make academia more inclusive while balancing #PhD research. https://scim.ag/3WRLJIL #InternationalStudentsDay
Please share with anyone who cares about NSF support for graduate students and take 30 seconds to sign and leave a comment. The deadline for the 2025 Graduate Research Fellowship Program is about one month away and literally no one can apply. #NSFGRFP jasonjwilliamsny.github.io/grfp2025/
An Open Letter to U.S. STEM Leadership on the NSF Graduate Research Fellowship Program
An Open Letter to U.S. STEM Leadership on the NSF Graduate Research Fellowship Program
jasonjwilliamsny.github.io
Spatial and functional diversity of innate lymphoid cells in the human female genital tract may contribute to antiviral responses to HIV @natimmunol.nature.com www.nature.com/articles/s41...
Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability @sciimmunology.bsky.social www.science.org/doi/10.1126/...
Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate
Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability.
science.org
Check out this @nature.com paper from the brilliant scientist I get to call my husband!!!!
Vincent Graziano@vinnieviruses.bsky.social · last yr.Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors www.nature.com/articles/s41...
Impaired stromal-epithelial cross-talk in Hirschsprung disease highlights the risk of epithelial damage, suggesting a therapeutic option www.science.org/doi/10.1126/...
Every cell is a stem cell! Even ‘terminal’ enterocytes can hit reset: Gut damage triggers a YAP/TAZ-driven fetal program → stress-proof “revival” stem cells → Lgr5⁺ CBC stem cells, rebuilding crypts from scratch and make organoids. #StemCellPlasticity #Organoids #Gut
Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells @natcomms.nature.com www.nature.com/articles/s41...
Our July issue is out today! Cover art depicts precision antibacterial strategies that allow non-toxigenic V. cholerae to dominate toxigenic rivals. www.cell.com/cell-host-mi...
I'm excited about a new @biorxivpreprint.bsky.social story that just went live! This one takes a #computational #immunology approach to understanding #tissueresident lymphocytes. The story highlights the extra value mathematical modelling can bring to biology. 🧵1/10 www.biorxiv.org/content/10.1...
Probabilistic migration events drive transient tissue residency of lymphocytes during homeostasis
Tissue-resident lymphocytes form a phenotypically and functionally distinct analog to the corresponding circulatory lymphocyte populations. Residential CD8 T cells, in particular, are identified as having prolonged residence in the tissues and key functions in recall responses at tissue-environmental interfaces, although the dwell time in individual tissues has yet to be resolved. Residential CD4 T cells, regulatory T cells, B cells, and NK cells have been demonstrated to share phenotypic properties with residential CD8 T cells, but the migratory kinetics are even more poorly defined. Here we used probabilistic modelling on a large parabiosis dataset, covering multiple time-points and tissues, to calculate migration kinetics and dwell times of multiple lymphocyte subsets across a diverse set of tissues. Markov chain modelling identified distinct cell type-specific and tissue-specific residency patterns. The liver and gut were prone to prolonged residency compared to other tissue types, and a hierarchy of residency was observed with CD8 T cells and NK cells demonstrating longer residency than CD4 conventional T cells and regulatory T cells, which in turn resided in tissues longer than B cells. With few exceptions, however, average residency was at least an order of magnitude shorter than the life-span of the mouse, indicating a more dynamic form of steady-state tissue residency than usually assumed. Together these data provide a comprehensive model of a pan-tissue shared program in lymphocyte tissue residence, as well as identifying cell type- and organ-specific modification of the migratory kinetics. ### Competing Interest Statement The authors have declared no competing interest. Wellcome Trust, https://ror.org/029chgv08, 222442/Z/21/Z European Research Council, TissueTreg
biorxiv.org
And NIH scientists know this better than anyone. www.nature.com/articles/s41...
The continued importance of animals in biomedical research - Lab Animal
In the rapidly evolving field of biomedical research, the role of animal models has long been a topic of scientific and ethical debate. However, despite advancements in alternative modeling approaches...
nature.com
Angie Rasmussen@angierasmussen.bsky.social · last yr.I’m all for more NAMS, but it has its limits. There are no LLMs or organs-on-a-chip that can model viral pathogenesis, vaccine efficacy, or candidate drugs. We only use animals when there is no other choice. This will only stop more lifesaving research. www.drugdiscoverytrends.com/nih-announce...
Excited to share this fun perspective on perinatal mucosal immune development! Check it out ➡️ www.sciencedirect.com/science/arti...
Exploring mucosal immune development and function in utero
Multiomics advances have led to breakthroughs in understanding human early life immunity. Adaptive memory immune cells have been detected in fetal tis…
sciencedirect.com
Spatial single-cell analysis identifies #placental villi structural and immune remodeling across #gestation from @konnikovalab.bsky.social www.mucosalimmunology.org/article/S193...
RFK Jr. removes all members of CDC panel advising U.S. on vaccines predictable, but still extremely harmful for anyone. Infectious diseases will come back, they cannot be prevented but for preparing our immune system to control and fight them. www.cnbc.com/2025/06... 1/3
🚨 A new rule would let career scientists like NSF/NIH program officers be replaced by political appointees Already 14,000+ public comments, deadline is Friday 📣 Comments can be short. Courts consider them—and scientists with NSF/NIH experience are especially impactful Speak up! shorturl.at/WKuBj
Fetoplacental extracellular vesicles deliver conceptus-derived antigens to maternal secondary lymphoid tissues for immune recognition @jci-insight.bsky.social insight.jci.org/articles/vie...
We are #hiring! Please help share! Postdoc in #Immunology; B-cell biology We are recruiting a postdoc to lead projects on human B cells and plasma cells funded by the Gates Foundation and the NIH (The position is fully funded and not dependent on future grants). ghosnlab.science/join-us
Ghosn Laboratory — join us!
ghosnlab.science
The Sengupta lab is seeking research technicians to join its team. Ideal candidates must possess a passion for research and exceptional communication skills. Both early-career and experienced candidates are welcome. Email SenguptaS@chop.edu with CV and letter of interest with goals and expectations.
So I took a deep dive. New research shows public science delivers 140–210% returns and fueled 20% of U.S. productivity growth since WWII. Cuts now = $billions lost later. www.forbes.com/sites/johndr...
Trump’s NIH And NSF Cuts Estimated To Cost The U.S. Economy $10 Billion Annually
Economists find public R&D drives a quarter of U.S. productivity growth — and pays for itself
forbes.com
"to run a contest that you end up not funding as a private organization at this time is… both extremely wasteful of these people’s time, and just devastating in terms of morale." I spoke with @aniloza.bsky.social at STAT today about HHMI's decision not to fund this round of Hanna Gray applicants.
Private funder HHMI pauses postdoc fellowship
As HHMI pauses Hanna Gray fellowship applications, opportunities for young scientists shrink further, making them look overseas.
statnews.com
🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues. 📍 Where: Basel, Switzerland 📅 When: 26th–29th August 2025 📝 Registration deadline: 30th May 2025 Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social #EMBOBarrierTissues
Adaptive immunity in barrier tissues
Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…
meetings.embo.org
I will be recruiting new postdocs with start dates end 2025 - early 2026. If you'd like to work at the Pasteur Institute in the heart of Paris surrounded by amazing scientists, reach out to discuss possible projects on SynBio / Bacterial Immunity!
Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —from decades of NIH funded research www.nejm.org/doi/full/10.... @nejm.org www.nejm.org/doi/full/10.... www.nytimes.com/2025/05/15/h...
Well the NIH has cancelled the Women's Health Initiative, the largest study of women in history It has been running continuously since 1991 and has provided massive key knowledge about diseases in women Unreal www.science.org/content/arti...
NIH cancels its first and largest study centered on women
The Women’s Health Initiative has produced numerous influential findings
science.org
Evolutionary analysis of the #nuclease Artemis suggests an important role in the domestication of RAG-like #transposons, such as that which gave rise to V(D)J recombination. Conserved residues crucial for nuclease activity are also identified @plosbiology.org 🧪 plos.io/3RuyNpl
