What happened in India today teaches us a valuable lesson - To learn something new, one has to break their arrogance and pride, and Genz taught this #CJP
Manvendra Singh
@manusingh.bsky.social
#NewPI #Recruiting CNRS-CPJ and Director of Research - RETROGEN lab, Retroelements and Genome Regulation Necker Institute and Institut Imagine, Paris. Alum: Feschotte lab (post-doc), Izsvak Lab (PhD) and Max-Planck Institute.
🟠 Now open: ERC Starting Grant 2027 call for proposals! 🗓️ Deadline: 14 Oct 2026 📄 Call details: link.europa.eu/RwNMpX Planning to apply? Let our ERC Classes videos guide you through the application evaluation process. 👉 t.co/qGPy7Y8UhS #ERCStG #FrontierResearch @scienceinnovation.ec.europa.eu
Hi #TEsky, please remember that we have an amazing community in the TransposonsWorldWide slack channel (join.slack.com/t/transposon...), which I encourage you to join. Another great resource is tehub.org. Please share !
Join TransposonsWorldwide on Slack
Slack is a new way to communicate with your team. It’s faster, better organized, and more secure than email.
join.slack.com
Proud moment for the RetroGen Lab! 🎉 Congratulations to Federica Mantovani on her selection for an oral presentation at the CNET meeting in Montpellier—a well-deserved recognition of her hard work and a fantastic opportunity to represent our lab. Bravo! 👏 #ProudPI
Three Species in One House is Endless Entertainment One delegate refuses to acknowledge the other. The other delegate is desperately trying to make friends. And I’m the confused moderator wondering why nobody is speaking the same language.
📍5 minutes before journal club. Today’s paper was… let’s say, not exactly light one of our PhD students sat down at the piano and played to calm everyone’s neurons before we wrestled with the paper. 🎹📖 Lucky to work with them. #AcademicLife #PhDLife #JournalClub #Science #ResearchLife #LabLife
🔥Feeling so thrilled to see a story of our recent paper on Transposons and Preeclampsia on the front page of Femina Magazine. #TEsky www.femina.fr/article/gros...
Grossesse : une nouvelle piste pour détecter la pré-éclampsie plus tôt
Encore difficile à anticiper, la pré-éclampsie reste une complication redoutée de la grossesse. Mais une récente avancée scientifique, menée notamment par l’Institut Imagine, ouvre la voie à un dépist...
femina.fr
👋 Transposon lovers: registration is now open for the CSHL TE meeting! We have a 🔥 lineup of invited speakers and many slots for short talks selected upon abstract across all areas of TE biology. 🧬➰🧬 #TEsky Abstract deadline: July 10 meetings.cshl.edu/meetings.asp...
🔬 What if we could spot preeclampsia before symptoms appear? Research by @manusingh.bsky.social in Genome Biology shows ancient viral remnants in our DNA act as "molecular switches" for placental development—leaving traces in maternal blood when they malfunction. 🎥 www.linkedin.com/feed/update/...
#research #preeclampsia #genomics #medicalresearch #institutimagine | Institut Imagine
🔬 What if we could detect preeclampsia before the first symptoms even appear? That is the promise of new research led by Dr. Manvendra Singh, group leader at INEM - Institut Necker Enfants Malades, i...
linkedin.com
🔥Feeling so thrilled to see a story of our recent paper on Transposons and Preeclampsia on the front page of Femina Magazine. #TEsky www.femina.fr/article/gros...
Grossesse : une nouvelle piste pour détecter la pré-éclampsie plus tôt
Encore difficile à anticiper, la pré-éclampsie reste une complication redoutée de la grossesse. Mais une récente avancée scientifique, menée notamment par l’Institut Imagine, ouvre la voie à un dépist...
femina.fr
🧬 We are LIVE at the weekly MAGIC seminar at Imagine! Kicking us off is @joshwaterfall.bsky.social (@institutcurie.bsky.social ) presenting "Improved Out of Distribution Embeddings with AutoEncoders." Fascinating insights into computational biology! 🧵
🧫 Wrapping up today's fantastic MAGIC seminar is @manusingh.bsky.social (@inem-necker.bsky.social). His talk: "Single-Cell Mapping of the Reawakening of Ancient Foes in Ageing Disorders." A deep dive into the molecular & cellular mechanisms of Alzheimer. Thanks to all speakers & see you next week! 🧪
#TEsky Another paper in our TE ecology exploration of the Octopus out in BioEssays. Types of niches for TEs and what that could mean for their expression in neural tissue doi.org/10.1002/bies...
Transposon Ecology and the Octopus Genome
Transposable elements (TEs) are mobile strands of DNA prevalent in octopus genomes. TE activity in the octopus brain might reflect an organism-beneficial role in cognition; or could be a deleterious ...
doi.org
Our collaborative work is out now in CELL @cellpress.bsky.social We sugggest sildenafil as a repurposable drug for mitochondrial disease. A clinical trial is planned to start later this year. Thanks to collaborators, funders, and patient organizations! www.sciencedirect.com/science/arti...
Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy
Mitochondrial disease encompasses inherited disorders affecting mitochondrial function. A severe and untreatable form of mitochondrial disease is Leig…
sciencedirect.com
Ancient viral DNA drives preeclampsia in pregnancy | Max Delbrück Center www.mdc-berlin.de/news/news/an...
Ancient viral DNA drives preeclampsia in pregnancy
Researchers have uncovered the molecular details of how ancient viral DNA controls a gene linked to preeclampsia. The study, published in “Genome Biology,” builds on previous research and may lead to a diagnostic test to identify preeclampsia risk much earlier.
mdc-berlin.de
Happy Women’s Day 🎊🎊😊to all of us and especially three outstanding women leading science at the highest level around our Necker Campus. Fabiola, Bana, and Yasmine, the directors of Necker, IMAGINE and Pasteur Institutes, respectively. Proud to be part of this cluster.
Happy Holi everyone 🌈 A festival where poetry meets science as every color carries meaning, every wavelength shapes how we see the world. Train your eyes with colors and your heart with kindness. May peace, harmony, and love spread across every spectrum of humanity.
In a mouse model of Primrose syndrome, rhEPO reverses. This is preclinical & could be the first tangible therapeutic path. Huge thanks to Justus, @cakirumut.bsky.social , Klaus and Hannelore and to an amazing team. DOI: 10.1172/jci.insight.200021 #RareDisease #Neurobiology #TranslationalResearch
Stranded due to airspace closures. Major grant + revision deadlines piling up. War reaches far beyond borders — even those who think they’re uninvolved feel it. And yet this inconvenience is nothing compared to what others are enduring. Please choose peace. Humanity first.
Suggesting a potential therapy for these autism-related symptoms and intellectual disability… This issue’s Cover features work by Hannelore Ehrenreich & team on the improvement of Primose syndrome traits in mice following erythropoietin treatment: doi.org/10.1172/jci....
So thrilled to have our research as a cover feature at @insight.jci.org, showing recombinant human Erythropoetin can compensate for the loss of function caused by the genetic mutation. I hope this research will age well. Thanks Hannelore, Klaus, @cakirumut.bsky.social , Justus and ex-colleagues
JCI insight@insight.jci.org · 5mo agoSuggesting a potential therapy for these autism-related symptoms and intellectual disability… This issue’s Cover features work by Hannelore Ehrenreich & team on the improvement of Primose syndrome traits in mice following erythropoietin treatment: doi.org/10.1172/jci....
Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14
Ancient co-option of LTR retrotransposons as yeast centromeres - Nature
Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...
nature.com
Such a great award and the reward too. Very well deserved @m-vincendeau.bsky.social , Many congratulations and hopefully many more to come ☺️ Keep cementing the #TEsky up above and high.
Michelle Vincendeau@m-vincendeau.bsky.social · 6mo agoThanks to @afi-ev.bsky.social for funding our project @helmholtzmunich.bsky.social ! Excited to delve into new aspects of Alzheimers research! www.alzheimer-forschung.de/forschung/fo...
Incredible article and resource too. Congratulations @kaessmannlab.bsky.social
Kaessmann Lab@kaessmannlab.bsky.social · 6mo agoWe are thrilled that our study on the evolution of gene regulation in mammalian cerebellum development – led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social – is now out in @ScienceMagazine! www.science.org/doi/10.1126/...
Gave a talk at @institutcurie.bsky.social on Friday and honestly… it felt unreal. Speaking in the same place where Marie Curie carried out her radiation experiments reminds how long science lasts beyond us. Thnks Elena Zueva, @mburbage.bsky.social , Sebastian Amigorena, Josh Waterfall and Lorena 🙏🏽
🧠🧬 Psoriasis: Unraveling the Causes of Chronic Itching @belkaidlab.bsky.social and Institut Pasteur researchers show that an excessive immune response to skin microbes activates the IL‑17A pathway in nerves, leading to chronic itch and nerve regrowth. 👉 www.pasteur.fr/en/home/rese...
Psoriasis: Unraveling the Causes of Chronic Itching
In psoriasis and other inflammatory skin diseases, chronic itching or pruritus is a particularly distressing symptom for patients which remains difficult to treat today. Scientists at the Institut Pas...
pasteur.fr
🦠 Closing our session is @manusingh.bsky.social discussing the "Long Shadow of Viral Infections". He's showing how HIV & EBV can reactivate persistent, ancient Endogenous Retroviral proteins. A powerful reminder that our genome's history still dictates our health today!🧬
#TESKY 🎉 Phenomenal work! After the humans, the variety of mouse immune cell systems also co-opts transposon-derived enhancers/promoters. Big Kudos to Jason, Andrew Grimson, and @cedricfeschotte.bsky.social
Cedric Feschotte@cedricfeschotte.bsky.social · 7mo agoNew Year, New Paper!🎊 Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system www.biorxiv.org/content/10.6... Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵