Graphing and statistically analyzing data is challenging without coding expertise. This Community Page by @avishenoy.bsky.social introduces grafify online, a free, browser app for generating publication-quality graphs and performing statistical tests and comparisons. 🧪 #AcademicSky plos.io/3RpUg6E

Excited to share our paper, now out in @jcb.org! 🎉 Co-led with @georgegalea.bsky.social at embl.org, we uncover a new layer of spatiotemporal regulation of the #DNADamageResponse between the Golgi and the nucleus, revealing an active role of the Golgi in #DNArepair. doi.org/10.1083/jcb.... 📷by me ❤️

Amazing structures, and distinct binding modes, of TOPBP1 or ETAA1 activating the ATR-ATRIP kinase by an allosteric mechanism. In NSMB from Pavletich lab: www.nature.com/articles/s41...

Structural mechanism of TOPBP1 activating the ATR–ATRIP replication checkpoint kinase - Nature Structural & Molecular Biology

Li et al. present cryo-EM structures of the ATR–ATRIP complex bound to the ATR-activating domains of TOPBP1 and ETAA1; these reveal distinct binding modes and allosteric mechanism of activation for TO...

nature.com

"Good morning. Can you spare a few minutes to talk about our Lord and Saviour Godzilla"

You guuuuuyyyyzzzz! This is a freeze fracture electron microscope image of the nuclear pores in a nuclear membrane and you guuuuuyyyyzzzz I get paid to teach it! 🤓 😍 📷: fineartamerica.com/featured/fre...

Very excited to share our new Nature study! We discovered that replication stress stabilizes CTCF-dependent chromatin loops enclosing stressed nascent DNA, where G9a-mediated heterochromatin protects it from nucleolytic degradation. rdcu.be/frzLg Huge thanks to all our collaborators and co-authors!

Replication-stress-induced chromatin loops protect fork stability - Nature

Replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks.

nature.com

Registration for the 18th RNase H meeting is open! Join us at IMB Mainz from 04–06 November 2026 for the “RNase H 2026”, organized by 4R RTG and IMB Mainz. Don't miss this conference and register now via: 4r-rtg.de/rnase-h-2026/ #IMB #RNASEH2026 #4R-RTG

Our paper on the evolution of cellular miniaturization is now out in PNAS! www.pnas.org/doi/10.1073/... A short recap 🧵

Marco Fumasoni@marcofumasoni.bsky.social · 8mo ago

🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥 www.biorxiv.org/content/10.6...

Do vaccines save lives? Yep! Does antivaxx BS kill? Yep. 👇 Cervical cancer deaths for vaccinated young women fall to zero in England: study www.ctvnews.ca/health/artic...

Cervical cancer deaths for vaccinated young women fall to zero in England: study

The HPV vaccine for cervical cancer has reduced the risk of dying from the disease before the age of 30 in England to almost zero, the first study of its kind showed Thursday.

ctvnews.ca

🖤✨

After 9 months of major revisions, 2 out of 3 reviewers were stilll not satisfied, and the editor decided to reject our manuscript. It's been a whole year since we first submitted our paper to a journal, and I am back to timepoint zero 😭😭

Someone in the news departments of @nature.com or @science.org needs to take a look at this--its a huge scandal from the scientific supplier that has become a monopoly

Sholto David@sholtodavid.bsky.social · 3mo ago

Earlier this week I posted an example of a fake western blot provided by ThermoFisher to demonstrate the validity of a p53 antibody. I considered it an amusing curiosity. In fact Thermo Fisher Scientific has systematically manipulated antibody validation data!

We're getting the new Fairy Tail manga miniseries one week sooner!

New Fairy Tail Manga Miniseries to Start 1 Week Sooner on July 29

animenewsnetwork.com

SLX4IP acts as a genome-wide brake on BLM helicase activity to preserve replication fork stability under stress – both globally and at ALT telomeres Stephanie Panier @spanier55.bsky.social, Kavi Mehta @k4v1.bsky.social and coworkers link.springer.com/article/10.1...

SLX4IP limits replication stress globally and at ALT telomeres - The EMBO Journal

Faithful DNA replication is essential for genome stability, yet replication forks face constant stress. The Bloom syndrome helicase (BLM) safeguards fork integrity, but excessive BLM activity can itse...

link.springer.com

🎯

#Vegan #Burger, with a patty made out of lentils. Contains also vegan cheese, tomatoes, onions, cucumber pickles, ketchup, hummus and tahini. Really really good.

Okay so why was I the only one in the theater tonight who gasped when Ryan Gosling ran a centrifuge with two tubes in the whole thing, sitting right next to each other? Sorry was I the only scientist in the film society theater tonight??

We go live!!! Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social @replifate.bsky.social @epicrossborders.bsky.social replifate.eu/event/meetin...

Events for February 2026

06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...

replifate.eu

Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

PAF15–PCNA exhaustion governs the strand-specific control of DNA replication

Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

rdcu.be

Real-Time Segmentation and Classification of Birdsong Syllables for Learning Experiments https://www.biorxiv.org/content/10.64898/2025.12.19.695629v1

Mech Arena link.plrm.zone/sdlgo/ki0l4

Get Mech Arena

Download the game and send me a Friend invite!

link.plrm.zone

It was great to be part of this collaboration, I always admired Prof Maya Schuldiner's and Dr Ofir Klein's work. lnkd.in/dfabHSkx For the original papers developing the fluorescent scFvs technology in yeast: lnkd.in/d_KZ8WMK lnkd.in/dxt9MD6d

DNA replication initiation timing is important for maintaining genome integrity | Journal of Bacteriology journals.asm.org/doi/10.1128/...

DNA replication initiation timing is important for maintaining genome integrity | Journal of Bacteriology

The regulation of DNA replication is fundamental to cell growth and cell cycle control. In eukaryotes, under-initiation or over-initiation leads to genome instability. In bacteria, it is unclear how c...

journals.asm.org

Such a nice review for one of our latest research works!

European Research Council (ERC)@erc.europa.eu · last yr.

🔬 Stephan Hamperl ‪uncovered how clashes between #gene reading & #DNA copying inside cells drive disease. Their tools reveal new insights into #cancer, ageing & development. Read more 👉 europa.eu/!H7RtjQ #FrontierResearch #GeneEditing #Genetics #Oncology @www.helmholtz-munich.de

We look forward to the community's feedback!

Hamperl Lab@hamperllab.bsky.social · last yr.

Our latest research is online in the @biorxivpreprint.bsky.social! 🧬🎉 🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression. www.biorxiv.org/cgi/content/...

The BLS did exactly what it's supposed to do: provide accurate, nonpartisan data. When the numbers showed Trump's "economic boom" was actually a bust (33k jobs vs claimed 291k), he fired the messenger. After all, when it rains too much, true leaders fire the meteorologists.

We’re officially in Donald Trump’s mad king era

All the books that are fit to cook.

motherjones.com

I don't like the person I become when designing primers

I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....

Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation - Nature Cell Biology

Kefalopoulou, Rullens et al. develop Dam&ChIC to assay chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division a...

nature.com

RIF1 orchestrates a multi-step restoration of post-replicative H3K9me3 https://www.biorxiv.org/content/10.1101/2025.07.14.664777v1