MDPhDEquity

@mdphdequity.bsky.social

Women Physician-Scientists Supergroup @UCSF est. 2020 supporting+celebrating Women bridging Science+Medicine @UCSF and beyond http://womenphysicianscientists.ucsf.edu

congratulations Christina Homer on your publication! another one from this outstanding @hhmi.org Hanna Gray Fellow and physician-scientist at UCSF!! @christinahomer.bsky.social

PLOS Biology@plosbiology.org · last yr.

Coccidioides is a fungal #pathogen that forms a unique structure, the spherule. This transcriptomic study of #Coccidioides development reveals spherule-specific gene regulation, Ryp1-dependent virulence factors, and potential #antifungal therapeutic targets @plosbiology.org 🧪 plos.io/4cINMpl

Top: Micrographs of fixed samples from each flask at the time of RNA harvest. Endospore release was first observed on day 3. Bottom: Schematic of Regulation of gene expression in Coccidioides development. The data uncover regulatory modules in Coccidioides development. The majority of Coccidioides transcription factors (TFs), depicted as triangles in the figure, show enhanced expression in spherules compared to hyphae. These TFs, along with RYP1 (green hexagon) and a second regulator whose motif is reported here, guide the expression of endospore-associated transcripts and secreted effectors, including proteases. RYP1 also controls a core regulon, that is, expressed in both spherules and hyphae via a canonical RYP1 motif. Finally, in arthroconidia, RYP1 impacts the transcriptome, but likely through indirect regulation of one or more additional key regulators.

So glad to see this superstar, Dr. Carolyn Sangokoya, @rnahelix.bsky.social recognized for her founding of WPSS, which has been a huge source of support in my career path!

Mary Prahl, MD@mkprahl.bsky.social · last yr.

The incredible @rnahelix.bsky.social Dr. Carolyn Sangokoya and the formation of the Women’s physician scientists supergroup has had an incredible impact on my career! Great to see her celebrated! www.ucsf.edu/news/2025/03...

Let's keep telling the story of the devastating impacts of funding and the fallout of ending USAID Lives lost, livelihoods lost, compassion lost, kindness lost, solidarity and support lost. Like HIV there is a "death" tracker telling the story of devastation to TB programs. tb.impactcounter.com

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