WE'RE HIRING! Thanks to some recent successes with NIH funding, we're seeking two new postdoctoral scholars to join our team. See below for details. Please share widely and feel free to reach out with any questions!

How do nuclear compartments form inside cell nuclei? We show RNA glues certain loci together to form a nuclear compartment. This involves special GC-rich regions of highly expressed genes that also associate with nuclear speckles, but interactions between these loci are independent of speckles!

bioRxiv Genomics@biorxiv-genomic.bsky.social · 2w ago

Formation of an RNA-mediated nuclear compartment https://www.biorxiv.org/content/10.64898/2026.08.20.746005v1

Supremely excited to share our new paper in @natcellbio.nature.com With an updated genetic cGAMP reporter, we reveal that cGAS activation by DNA damage is a rare event, and that cGAS enrichment on intracellular structures cannot be taken as evidence of activation. www.nature.com/articles/s41...

A versatile cGAMP reporter reveals principles of cGAS activation by DNA damage and chromosome instability - Nature Cell Biology

Lebrec et al. present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chroma...

nature.com

Delighted to share our latest publication, a collaborative work with @hanasedlackova.bsky.social and @puckknipscheer.bsky.social. Grateful to everyone who contributed to this project. www.cell.com/cell-reports...

FANCJ and RTEL1 facilitate pre-replication complex disassembly following replisome collision

Cameron et al. show that dormant pre-replication complexes are removed upon collision with replication forks in Xenopus egg extracts. They identify FANCJ and RTEL1 as key factors in this process and s...

cell.com

📢 Applications are now open for the NIH Stadtman Tenure-Track Investigator Program! We're recruiting early-career scientists across all areas of biomedical research for tenure-track faculty positions in the NIH Intramural Research Program. Deadline: Sept 30, 2026. 🔗 tinyurl.com/stadtman26

MCB is hiring Assistant Professors across 3 divisions!: 🧪BBS: aprecruit.berkeley.edu/JPF05483 🧬GGED: aprecruit.berkeley.edu/JPF05481 🦠IMM: aprecruit.berkeley.edu/JPF05486 🗓️ Application Deadline: October 19, 2026 🔗 Click the links or scan the QR codes to learn more and apply

What if the much-debated mechanisms of PARP inhibitors vary greatly across tissues and tumor subtypes? Our new preprint reveals surprising links between replication fork dynamics and PARPi sensitivity across acute myeloid leukemia (AML) subtypes. www.biorxiv.org/cgi/content/...

Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.

Fred Hutch Basic Sciences Division@basicsci.fredhutch.org · last mo.

Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.

Pls share. Assistant Professor of Biological Sciences - Genetics/Genomics at Smith College. apply.interfolio.com/190342

Thrilled to share a new preprint from the lab, showing that active fork slowing and reversal is not confined to the damaged subnuclear compartment but rapidly extends throughout the nucleus, via non-canonical ATR signaling and modulation of MRN exonuclease activity. www.biorxiv.org/cgi/content/...

Non-canonical ATR signalling via NBS1 phosphorylation propagates fork slowing from stressed to unperturbed nuclear regions

DNA replication forks frequently encounter obstacles and remodel into four-way junctions to actively slow DNA fork progression. Fork slowing can also spread to undamaged forks via an ATR-dependent mec...

biorxiv.org

Reminder — UW #Microbiology has an open search for an Assistant Professor, focusing on fundamental problems in #bacteriology! If you or someone you know would be suitable, here's the ad: apply.interfolio.com/185622

The Ly Lab is recruiting two #postdocs to study intercellular DNA transfer. Join us to tackle fundamental questions at the intersection of genome instability, cell-cell communication, and cancer evolution. Please share! 🙏 Full posting: cri.utsw.edu/careers/

Interested in studying nuclear condensates across the cell cycle? Our latest methods paper in STAR Protocols may be exactly what you are looking for! Here, we describe a high-throughput, novel imaging approach that tracks condensate dynamics in human cells. www.sciencedirect.com/science/arti...

Protocol for cell cycle-resolved high-content imaging of transcription condensate dynamics in human cells

Transcription condensates are dynamic, phase-separated compartments that control gene activation. Here, we present a protocol for studying transcripti…

sciencedirect.com

Out today - structure of the human HIRA histone chaperone complex bound to nucleosomes. Ever wondered how nucleosomes are assembled in the wake of transcription? It takes a 'hulk of a protein complex'. Work by the amazing Wei Tian weetian558.bsky.social. www.biorxiv.org/content/10.6... 🧵

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...

Small contribution to the eternal match happening inside every cell: in the red corner, replication. In the blue corner, transcription. Both convinced they own the genome. Another amazing collaboration with @hamperllab.bsky.social and @luijsterburglab.bsky.social lnkd.in/ey9tH7YF

Excited to share a new preprint from the lab by @melissamcevoy.bsky.social The S/G2 checkpoint prevents the premature shutdown of the DNA replication program. Without it, cells fail to finish replicating their chromosomes and have severe mitotic errors. www.biorxiv.org/content/10.6...

Interested in microbiology, immunology, and host-pathogen interactions? Come work with us! Our department at OHSU is opening a search for a new tenure-track faculty position. See the job advertisement for details. Please share within your networks! www.nature.com/naturecareer...

Faculty Position in Molecular Microbiology and Immunology - Portland, Oregon job with Oregon Health & Science University (OHSU) - Molecular Microbiology and Immunology | 12858852

The Department of Molecular Microbiology and Immunology at OHSU invites applications for a tenure-track Assistant or Associate Professor position.

nature.com

New preprint out today from the lab! congrats to Celina Sanchez on this exciting work! check it out: www.biorxiv.org/content/10.6...

We are excited to launch the full program for the 2026-2027 season of the Genome Integrity Italian Network webinars! Join us every first Tuesday of the month via Zoom: uzh.zoom.us/j/6598481621... Subscribe here to receive a calendar file with all webinars: docs.google.com/forms/d/e/1F...

Are you a recent Ph.D. graduate? Apply for the Science & SciLifeLab Prize for Young Scientists. The $30,000 grand prize will be awarded for outstanding research in cell and molecular biology, genomics, ecology, or molecular medicine. Apply by 15 July: https://scim.ag/4lUpKMN

Science & SciLifeLab Prize for Young Scientists

This Prize was created to recognize that global economic health is dependent upon a vibrant research community and we need to encourage our best and brightest to continue in their chosen fields of res...

scim.ag

Excited to share our @natprot.nature.com paper on using RNA proximity labeling to map subcellular RNA transcriptomes. We’ve been working in this area for a while and wanted to create a resource paper to guide the uninitiated reader. rdcu.be/fblvI

APEX-seq maps transcriptome-wide subcellular RNA localization in living cells

Nature Protocols - This Protocol describes the transcriptome-wide labeling of RNAs in a particular subcellular compartment using proximity biotinylation by localized APEX2 enzyme and subsequent...

rdcu.be

Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks

Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks

Li et al. uncover a new mechanism, fork-MMEJ, at broken replication forks that repairs seDSBs with characteristics distinct from the canonical MMEJ (cMMEJ). This study provides insights into replication-associated DSB repair, implicates microhomology-mediated chromosomal rearrangements in cancer, and offers potential therapeutic strategies to selectively target cancer cells.

dlvr.it

Another great opportunity for genome integrity / replication stress aficionados to attend two excellent seminars with a simple click. Join us in a few days (Tue April 7th)! 👇

To kickstart this new Bluesky account: We're hiring! The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab. Details in the flyer — get in touch! 👇

🧵 Thread: What happens when transcription isn’t properly shut off during mitosis? Our new preprint explores just that 👇 www.biorxiv.org/content/10.6...

Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

PAF15–PCNA exhaustion governs the strand-specific control of DNA replication

Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

rdcu.be

I am excited to share the first paper from the Saldivar lab! A special thank you to all who contributed. Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability: Molecular Cell www.cell.com/molecular-ce...

Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability

Marmolejo et al. uncover transcription condensate dynamics at histone locus bodies across the cell cycle. These dynamics are governed by cell cycle (DDK and CDK1/2) and checkpoint (ATR-CHK1) kinases t...

cell.com