doi: doi.org/10.1038/s414... 📣 Our study is now out in Nature Communications detailing that the type I interferon pathway is suppressed by HUSH in early human development: Its complete epigenetic lockdown!! Incredible work from James Holt 📣 😎
@michael-imbeault.bsky.social
New preprint! In an fun collaboration with @imaeso.bsky.social and @mirimiam.bsky.social led by Manu F-M, we set to explore the potential adaptation of transposable elements 👾 to host adenine DNA methylation by recruiting prokaryotic DAM methyltransferases: www.biorxiv.org/content/10.6.... 1/6
biorxiv.org
Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.
Igor Ulitsky@igorulitsky.bsky.social · 9mo agoA preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
💥 Great fun writing this #review with @alejotorrescano.bsky.social – reflecting on the emergence of #pancreatic #lineages in the #embryo through the lens of #plasticity - Just out online ➡️ rdcu.be/fiw3c @wellcometrust.bsky.social @kingscollegelondon.bsky.social @kingslsm.bsky.social
Understanding development and cellular plasticity in the pancreas in health and disease
Nature Reviews Gastroenterology & Hepatology - Pancreatic development is a dynamic process. This Review discusses the development and cellular plasticity that occurs in the pancreas in health...
rdcu.be
Excited to share our new study on CpG islands (CGIs) regulation by transcription factors (TFs)! CGIs drive most transcription initiation with unclear regulation. We find that chromatin-opening TFs are key players—following a surprisingly simple rule. 🧵 www.biorxiv.org/content/10.6... 1/9
biorxiv.org
Excited to share our Nature Genetics Research Briefing on how the repetitive genome helps shape leukemia stemness. We found that transposable elements sustain stem-like states in AML and predict patient outcomes. www.nature.com/articles/s41...
Alterations of chromatin state at transposable elements rewire stemness in acute myeloid leukemia - Nature Genetics
By mapping chromatin accessibility over transposable elements (TEs) across normal hematopoietic cells and the various cell types of primary acute myeloid leukemia (AML), we identified TE subfamilies w...
nature.com
Thrilled to present our comparative study on the evolution of zygotic genome activation (ZGA)!! 🥚🧬 Amazing PhD work of @campobes.bsky.social together with @fedemantica.bsky.social and many collaborators! @melisupf.bsky.social @crg.eu. Thread below 1/15 www.biorxiv.org/content/10.6...
biorxiv.org
Associate Senior Lecturer/Assistant Professor position in Molecular Microbiology available at Lund University, Sweden: lu.varbi.com/en/what:job/...
Associate Senior Lecturer/Assistant Professor in Molecular Microbiology
The Department of Biology conducts research and teaching in many subject areas such as ecology, evolutionary biology, organismal biology and molecular biology. A total of approximately 300 people curr
lu.varbi.com
A week left to apply to our fully funded PhD studentship (thanks to the Generation Trust!) - entry point updated to either June or October (so no worries if you are currently finishing your MPhil!). Don't hesitate to contact me with any questions about the opportunity or the project itself.
@michael-imbeault.bsky.social · 5mo agoWe have a fully-funded PhD studentship opportunity in my group to study primate-specific gene regulatory networks related to inflammation and DNA damage, in collaboration with @frostlab.bsky.social - please apply or send to promising candidates (UK Home fees eligible only), deadline is March 18th.
If you’re at #dros26 and you like transposons don’t miss Peiwei’s talk! 🔥🪰 We’re really excited about his findings!
Peiwei Chen@peiwei-chen.bsky.social · 5mo agoWhat happens if the germline goes on without (most of the) piRNAs for 45 generations? Come find out at my talk at the evolution session on Saturday at #dros26 @genetics-gsa.bsky.social 🪰🔬🔎⁉️🤔
🚨 Job Alert - Please share! 🙏 Interested in 3D gene regulation in development & evolution? 🤓🧬 💥 Our lab at @cabd-upo-csic.bsky.social is expanding! We’re recruiting: ✅ PhD students ✅ Postdocs 💻🧪 Experimental or computational backgrounds welcome 👇 Details below
Team ILLUMINE, featuring our Hannon Group, will receive up to $25m over five years to take on the challenge of the dark proteome as part of Cancer Grand Challenges. Full story: www.cruk.cam.ac.uk/news/hannon-...
We have a fully-funded PhD studentship opportunity in my group to study primate-specific gene regulatory networks related to inflammation and DNA damage, in collaboration with @frostlab.bsky.social - please apply or send to promising candidates (UK Home fees eligible only), deadline is March 18th.
Primate-specific gene regulatory networks responsive to inflammation and DNA damage
This project will investigate gene regulatory networks controlled by primate-specific transposable elements responsive to inflammation and DNA damage and probe how they are disrupted in cancer.
kcl.ac.uk
Molecular #evolution of animal #aging: A field perspective explores the impact of evolution on aging and offers a multi-angle view on longevity variation across model organisms and environments link.springer.com/article/10.1...
Are you interested in achieving efficient silencing of transposable elements using CRISPRi? 🧬 🧫 Go ahead and have a look at this STAR protocols where Adami et al. share all the tips & tricks they use in the Jakobsson lab. @anitaada.bsky.social @raquelgarza.bsky.social @jakobssonlab.bsky.social
Protocol for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells
Here, we present a workflow for transcriptional silencing of transposable elements (TEs) in human induced pluripotent stem cells (hiPSCs). We describe steps for designing guide RNAs (gRNAs) to target ...
cell.com
TE x ZFP = Evolution! Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
Olga Rosspopoff@orpsf.bsky.social · 9mo agoThrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social #TEsky #TEworldwide authors.elsevier.com/c/1m6MC,LqAZ...
Today in @science.org: We are pleased to present our last work entitled: "Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis" by Zumalave et al. www.science.org/doi/10.1126/...
Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis
LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read...
science.org
If you want to explore ncRNA dynamics during mammalian development, love microscopy, and are not afaraid of transposons biology, apply‼️ We are looking for a postdoc to join our team at @imbavienna.bsky.social More details 👇🏻
Institute of Molecular Biotechnology@imbavienna.bsky.social · 5mo agoWe are hiring! Join the Jachowicz lab as a postdoctoral researcher. The project focuses on understanding the dynamics of ncRNAs using high-resolution and single-molecule microscopy approaches. Link below 👇
Find our latest Perspective article in Nature Genetics on "The role of KRAB zinc-finger proteins in expanding the domestication potential of transposable elements" at www.nature.com/articles/s41..., with implications for the future of research on the cause of human disease.
The role of KRAB zinc-finger proteins in expanding the domestication potential of transposable elements - Nature Genetics
This Perspective explores the co-evolution of transposable elements and KRAB zinc-finger proteins in relation to their integration into human gene regulatory networks, highlighting their potential eff...
nature.com
Finally found the time to make a BlueSky account, last year was very busy moving to London for my new position at King's College London, looking forward to rejoin the amazing transposable element community!