Really excited to share the publication of my PhD work in the Jin Zhang lab at UCSD! You can find it here in Nature Chemical Biology. www.nature.com/articles/s41...

A chemigenetic endogenous Ras activity biosensor for live-cell pharmacology - Nature Chemical Biology

Here the authors present a biosensor for measuring endogenous Ras in live cells, based on HaloTag and the fluorogenic JF635 dye, and they use it to report location-specific inhibition profiles of dist...

nature.com

🚨 2x PhD opportunities: single-molecule/super-resolution microscopy & image analysis of membrane proteins 🔬(DM for details) 👉🏻 tinyurl.com/5dt7ncby 👉🏻 tinyurl.com/5e52dth2 🙏 Dear colleagues & friends, pls distribute - Thank you! 🙏 @crc1507.bsky.social imol.uni-frankfurt.de @goetheuni.bsky.social

We're thrilled to unveil our fantastic line-up of selected speakers for SMLMS 2026 at smlms.org Huge congratulations to them! 🎉 Missed the deadline? Good news! Registration and poster abstract submission have been extended until 31st July! 🔬✨

📢 I'm thrilled to announce that I'll be joining the HHMI Janelia Research Campus as a Group Leader in MTI! It's an honor to be part of Janelia's Next Chapter, pushing dye development and imaging technologies into new dimensions. The Lincoln Lab launches Sept. 14th, stay tuned for more info! 🔬⚗️👨🏼‍🔬

Gather round for the story of the Very Hungry Data Centre... 🧵 (1/4) #datacentre #ai

My department @eth-dbiol.bsky.social at ETH Zurich is hiring for a tenured professor in mol cell bio and biochemistry (associate/full). The position is within the Institute of Biochemistry (www.bc.biol.ethz.ch) and it is fairly open within their scope of research. www.nature.com/naturecareer...

Professor of Molecular Cell Biology and Biochemistry - Zurich, Switzerland job with ETH Zurich | 12861386

The Department of Biology at ETH Zurich invites applications for the above-mentioned tenured professorship at the Institute of Biochemistry

nature.com

New plasmids from Kai Johnsson now online! 💡 The self-labeling CLIP-tag2 achieves almost 1000-fold faster tagging than the original when combined with a new substrate optimized for live-cell imaging. https://twp.ai/4hrKYy

We are again looking for 3 Flash Talks for the 6th Virtual @chembiotalks.bsky.social. If you are a PhD candidate or postdoc in the field of #ChemBio, I strongly encourage you to apply via our abstract challenge: chemistry-europe.onlinelibrary.wiley.com/hub/journal/... #ChemBio #ChemSky #Competition

Are you a #PhD candidate or #postdoc and do you want to present your #ChemBio research to a large audience? Here is your chance. You can apply through our abstract challenge to present at the 6th Virtual ChemBioTalks on September 29th. chemistry-europe.onlinelibrary.wiley.com/hub/journal/...

In 1915, Gillette began convincing women that leg & armpit hair were embarrassing, masculine & unhygienic--to sell razors. A norm that has no health benefits but incredible compliance. Women are called 'disgusting' when they have the same body hair as men. www.thepersistent.com/tangled-hist...

The Tangled History of Women and Body Hair

Is it time, finally, to push back?

thepersistent.com

Still obsessed with histidine (and its mimics)! Our latest work from Benjamin 🎉 uses genetic code expansion—tuning the primary coordination sphere of a dizinc metallohydrolase—lowering the catalytic pKa and boosting activity up to 5x at acidic pH. Check it out! doi.org/10.1021/acs.biochem.5c00768

Catalytic pKa Attenuation in a Hydrolytic Metalloenzyme by Genetic Code Expansion

Hydrolytic metalloenzymes employ Lewis-acidic metal cofactors to activate water molecules, generating nucleophilic hydroxide species that facilitate catalysis. Their catalytic efficiency across a wide...

doi.org

🚨 Are you in need of a sensitive ratiometric protein kinase A (PKA) biosensor? 🚨 We got you covered: far-red, large changes, rapid response kinetics, selective! Anything you could wish for. Check out these two preprints from the Zhang Lab 🧪 🧑‍🔬 Congrats to everyone involved!

Jin Zhang Lab @jinzhanglab.bsky.social · 8mo ago

🚨🚨Double preprint alert! 🚨🚨 Two papers went up on Biorxiv this week! The first presents new chemigenetic FRET-based biosensors: www.biorxiv.org/content/10.6... And the second presents an improved version of our C-Y FRET PKA reporters, AKAR6 www.biorxiv.org/content/10.6... Thread 🧵 1/5

No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition. Which just makes me want to share it again: www.nature.com/articles/d41...

Gladys Mae West obituary: mathematician who pioneered GPS technology

She made key contributions to US cold-war science despite facing huge barriers as a Black woman.

nature.com

🚨How do we implement synthetic fluorophores into biosensors? Have a look at Elias Dressler’s review article in Chimia. The issue highlights the work of Young Professors and Ambizione Fellows in Switzerland. Glad to be part of this vibrant community. ⚗️ www.chimia.ch/chimia/artic...

A new Review by Agnese Nicoli and Michelle Frei examines the progress in developing synthetic small-molecule fluorophores and how these in combination with innovative labeling strategies can advance chemical biology www.nature.com/articles/s41...

Synthetic fluorophores for live-cell fluorescence microscopy and biosensing - Nature Chemical Biology

Performing live-cell microscopy experiments with high spatial and temporal resolution requires fluorophores with highly optimized properties. This Review examines the progress in developing synthetic ...

nature.com

🚨Curious how synthetic fluorophores simplify microscopy? Our review covers applications such as super-resolution microscopy and biosensing. 🎉👩‍🔬Congrats to my first PhD student, Agnese Nicoli, for the fearless deep dive! 🔬 ⚗️ D-CHAB @ethz.ch www.nature.com/articles/s41...

Synthetic fluorophores for live-cell fluorescence microscopy and biosensing - Nature Chemical Biology

Performing live-cell microscopy experiments with high spatial and temporal resolution requires fluorophores with highly optimized properties. This Review examines the progress in developing synthetic ...

nature.com

🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9

Hijacking a bacterial ABC transporter for genetic code expansion - Nature

Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...

nature.com

#Mifobio2025 Focus on the module 1 : 👉 "Marking strategies at different scales of life" We are delighted to welcome @michellefrei17.bsky.social @ethz.ch Lecture : "Chemigenetic kinase biosensors for multiplexed activity sensing and super-resolution imaging" 👉 imabio-cnrs.fr/mifobio-2025/

The 5th Virtual @chembiotalks.bsky.social on September 30th are one week away. We have an exciting program including our keynotes Sarah O'Connor (@oconnorlab.bsky.social) and @craigmcrews.bsky.social. Make sure to register for free: web.cvent.com/event/... #ChemSky #ChemBio

This is a really, really important story, which is why I provided a gift link. Many people, when they think of higher education, think of elite universities. But most higher education is nonselective (i.e., they admit everyone), and a lot of it is community colleges.

hilzoy@hilzoy.bsky.social · last yr.

Gift link: www.nytimes.com/2025/08/04/m...

🚨 2 × PhD positions @EPFL! 🚨 Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → fschueder@ethz.ch #PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT

💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭: #nanopores #smFRET #biomolecular #dynamics #singleMolecules We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech. Please share broadly, thank you!🤝 schmid.chemie.unibas.ch

We have multiple PhD and Postdoc positions open in my new group at Masaryk University. Are you an excellent and motivated candidate interested in organic and peptide synthesis and chemical biology? Get in touch! Start in January 2026. www.fialalab.com Appreciate sharing!

Teaching an old bacterial protein new tricks: Fast, bright and reversible rhodamine tags for live-cell imaging: www.biorxiv.org/content/10.1... Congratulations to Julian Kompa and the entire team.

Fast, Bright and Reversible Rhodamine Tags for Live-Cell Imaging

We present Rho-tag and SiR-tag, engineered protein tags derived from bacterial multidrug-resistance proteins that bind unsubstituted (silicon-) rhodamines with nanomolar affinity, enabling fast, rever...

biorxiv.org

📣Paper alert! Interested in faster and brighter protein labeling than before? 👀 @steffi-k.bsky.social & other colleagues have developed an improved tool for labeling proteins with synthetic fluorophores for bioimaging. Also works in STED microscopy 🤩🔬 Congratulations!🥳 www.nature.com/articles/s41...

SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology

SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...

nature.com

We are hiring! Check out our open PhD position for an exciting industry collaboration with Novo Nordisk: jobs.ethz.ch/job/view/JOP...

PhD Position in Peptide-Based Drug Discovery (Industry Collaboration, w/m/d)

jobs.ethz.ch

🔥 We've already received over a third of pre-registrations! #Mifobio2025 is already shaping up to be a highly attractive event... Don't delay in pre-registering! 👉 imabio-cnrs.fr @cnrs.fr @cnrsbiologie.bsky.social @cnrsingenierie.bsky.social @cnrs-inist.bsky.social

GdR ImaBio 🔬@gdrimabio.bsky.social · last yr.

🔥It's D-day. We're opening pre-registration for #Mifobio2025 today🔥 👉 This is the 11th edition of the Thematic School! All the relevant information, as well as the pre-registration form, is easily accessible on imabio-cnrs.fr but only if you are logged on this site. 👉Deadline June 10, 2025 ❗

Want to be part of the 5th Virtual ChemBio Talks? Submit you abstract until 📅 June 30th. Two amazing keynote speakers @oconnorlab.bsky.social and @craigmcrews.bsky.social are already confirmed. More coming soon. Stay tuned! ⚗️👩‍🔬🦠🧑‍🔬

Virtual ChemBioTalks@chembiotalks.bsky.social · last yr.

Do you want to present your #ChemBio research to a global audience at the 5th Virtual ChemBio Talks? If you are a #PhD or #postdoc, here is your chance! Apply for a Flash Talk via our abstract challenge. Deadline is June 30th. #ChemSky chemistry-europe.onlinelibrary.wiley.com/hub/journal/...

Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social! www.nature.com/articles/s41...

Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - Nature Biotechnology

Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.

nature.com

My lab at @ethzurich.bsky.social is looking for a motivated PhD student. We develop chemical tools for advanced fluorescence microscopy 🔬 and work at the interface of synthetic chemistry ⚗️ and protein engineering 🦠. Sharing with skilled Master students appreciated. More info at tinyurl.com/2dbjk5ty