Emerging autism and Fragile X syndrome treatments

The limitations of current symptom-focused treatments drive the urgent need for effective therapies for autism and Fragile X syndrome (FXS). Currently…

sciencedirect.com

Social disadvantage accelerates aging - Nature Medicine

Individuals with social disadvantage, during both early and later life, have an increased risk of 66 age-related diseases mediated by 14 age-related proteins.

nature.com

Women twice as likely to develop Alzheimer’s disease as men — but scientists do not know why - Nature Medicine

Changes to the female brain during menopause, together with social and cultural factors, might affect disease risk.

nature.com

Aging activates escape of the silent X chromosome in the female mouse hippocampus

Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.

science.org

AAIC Satellite Symposium | Alzheimer’s Association

Join leading research experts at the 2025 AAIC Satellite Symposium in Lima, Peru, and online to network & explore emerging dementia research.

alz.org

Virtual dialogue: brain health | World Dementia Council

bit.ly

Pain-Related Memory Impairment: How does chronic pain lead to memory loss?

A dysfunctional signaling pathway in the hippocampus has been linked to chronic pain-related memory impairment in mice.

elifesciences.org

Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts - Molecular Psychiatry

Molecular Psychiatry - Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts

nature.com

Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts - Molecular Psychiatry

Molecular Psychiatry - Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts

nature.com

Biological sex matters in brain aging

Every cell in the body has a biological sex. The expansion of aging research to investigate female- and male-specific biology heralds a major advance …

sciencedirect.com

Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease - Nature Neuroscience

This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several strategies are pr...

nature.com

Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice - Nature

A comprehensive single-cell RNA sequencing study delineates cell-type-specific transcriptomic changes in the brain associated with normal ageing that will inform the investigation into functional chan...

nature.com

a cartoon cat looking at a christmas tree in a pink room

ALT: a cartoon cat looking at a christmas tree in a pink room

media.tenor.com

RNA encodes physical information

Most amino acids are encoded by multiple codons, making the genetic code degenerate. Synonymous mutations affect protein translation and folding, but their impact on RNA itself is often neglected. We ...

biorxiv.org

Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

Neuronal dendrites must relay synaptic inputs over long distances, but the mechanisms by which activity-evoked intracellular signals propagate over ma…

sciencedirect.com

Heroes of the Engram

In 1904, Richard Semon introduced the term “engram” to describe the neural substrate responsible for (or at least important in) storing and recalling memories (i.e., a memory trace). The recent introd...

jneurosci.org

Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy

Jacquet et al. shows that microglia use digestive exophagy to engage large Aβ deposits that cannot be phagocytosed, forming acidic extracellular compartments on the aggregates into which lysosomal enzymes are exocytosed. The PI3K-AKT pathway modulates this process. Microglia also exocytose intralysosomal undigested fibrillar Aβ toward extracellular aggregates, potentially contributing to plaque growth.

cell.com

Neuroinflammation in Alzheimer disease - Nature Reviews Immunology

This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...

nature.com

Understanding the molecular diversity of synapses - Nature Reviews Neuroscience

The set of proteins present at synapses determines their heterogeneous functions and properties. In this Review, van Oostrum and Schuman describe the molecular mechanisms that contribute to the d...

nature.com

Alector Announces Results from AL002 INVOKE-2 Phase 2 Trial in Individuals with Early Alzheimer’s Disease and Provides Business Update | Alector

SOUTH SAN FRANCISCO, Calif. , Nov. 25, 2024 (GLOBE NEWSWIRE) -- Alector, Inc. (Nasdaq: ALEC), a clinical-stage biotechnology company pioneering novel, genetically validated therapies for the treatment...

investors.alector.com

‘Dark proteome’ survey reveals thousands of new human genes

Database confirms that overlooked segments of the genome code for a multitude of tiny proteins

science.org

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease - Nature Neuroscience

Using cryo-electron tomography (cryo-ET) and proteomics, this study identifies the tethering of pathological tau filaments within defined brain extracellular vesicles in Alzheimer’s disease, shining l...

nature.com

Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy

RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...

science.org