Very excited to share our new Nature study! We discovered that replication stress stabilizes CTCF-dependent chromatin loops enclosing stressed nascent DNA, where G9a-mediated heterochromatin protects it from nucleolytic degradation. rdcu.be/frzLg Huge thanks to all our collaborators and co-authors!

Replication-stress-induced chromatin loops protect fork stability - Nature

Replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks.

nature.com

Audrey, superstar postdoc in my lab is sadly moving on but not before seeing her first author work published! www.linkedin.com/posts/audrey...

Replication origin firing capacity indicates ATR inhibitor sensitivity - Nature Communications | Audrey Lumeau

We are thrilled to share that our latest work has been published in Nature Communications! 🎉 In our study, we identify replication origin firing capacity as a key determinant of cellular sensitivity ...

linkedin.com

Fantastic experience chairing and organising inaugural London Genome Instability Conference (LOGIC) at @qmbci.bsky.social with @audreylumeau.bsky.social & @mollyguscott.bsky.social , brilliant talks on DNA damage, cancer initiation and genome evolution. Looking forward to doing it again next year!

Now online! Genome instability triggers intercellular DNA transfer between human cells

Genome instability triggers intercellular DNA transfer between human cells

Mammalian cells can pass damaged pieces of their genome directly to neighboring cells via contact-dependent, nanotube-like connections. These transferred DNA fragments persist and function, revealing an unexpected route by which genome damage can propagate between cells.

dlvr.it

If you work on quantitative cancer genomics, please consider submitting an abstract for our next "Cancer Population Genetics Club" #CANPOP meeting hosted @icr.ac.uk on 15 June 2026. CANPOP is free to attend. Registration & abstract submission here: docs.google.com/forms/d/e/1F...

Our new review on NHEJ just came out on G&D genesdev.cshlp.org/cgi/content/... Highlight the 5 phases, and importantly, the 5 protein bridges that bring the 2 DNA ends together for NHEJ. Thank Dr. Geunil Yi, for generating the illustration for all structural models.

Excited for this film showcasing the important work my lab @mcclellandlab.bsky.social and other labs do at @qmbci.bsky.social . Attacking cancer from all angles with 1st class research by some amazing colleagues

Barts Cancer Institute (Queen Mary University of London)@qmbci.bsky.social · 6mo ago

Today, on #WorldCancerDay, we’re taking you behind the scenes at Queen Mary's Barts Cancer Institute and introducing you to the people who are making progress possible. Follow us to stay up to date with new developments. 🧪 #UnitedByUnique #MedSky #OncoSky @qmul.bsky.social @cancerresearchuk.org

Drs Without Borders refused to hand over staffing lists to Israel because they have habit of targeted murder of medical staff: Israel then bans the medical charity from Gaza. Keep that in mind next time you interact with Israeli institutions www.bbc.co.uk/news/article...

Israel to ban MSF from working in Gaza over refusal to provide staff list

Medical charity Medicine Sans Frontières said it would not share the list as it had not been able to ensure staff would remain safe.

bbc.co.uk

Are you fascinated by cancer biology and also ❤️ 💻 ? Feel like this ->😻<- at the thought of exploring oodles of cancer genomes, single cells and spatial multiomics data? Then our core Data Science Team at @icr.ac.uk might be the place for you. Vacancy here: jobs.icr.ac.uk/vacancies/14...

Data Scientist in Sutton | The Institute of Cancer Research

View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 - £53,500 (Salary appointment dependent on experience ) Reporting to: P...

jobs.icr.ac.uk

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

An integrated view of the structure and function of the human 4D nucleome - Nature

The 4D Nucleome Project demonstrates the use&nbsp;of genomic assays and computational methods to measure&nbsp;genome folding and then&nbsp;predict genomic structure&nbsp;from DNA sequence, facilitatin...

nature.com

Deadline is very soon (12pm November 5th) so get those applications in for a PhD position at Barts Cancer Institute working on radiotherapy resistance , copy number alterations and chromosomal instability !

@nadeemshaikh.bsky.social · 10mo ago

Apply to join our lab for a very cool PhD project studying radiation therapy, chromosomal instability, DNA repair and cancer evolution!

It’s time for academics and academic institutions to do the right thing www.soas.ac.uk/about/news/s...

Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com doi.org/10.1038/s414... doi.org/10.1038/s414...

A follow-up PhD project is now available: www.findaphd.com/phds/project...

Regulation of Ribonuclease H2 for control of R-loops and genome stability at University of Birmingham on FindAPhD.com

PhD Project - Regulation of Ribonuclease H2 for control of R-loops and genome stability at University of Birmingham, listed on FindAPhD.com

findaphd.com

Eva Petermann@petermannlab.bsky.social · last yr.

We're very proud that our recent PhD graduate (and now postdoc) Rosie Wilkins' study on RNase H2 overexpression in human cells has been published in Oncogene. www.nature.com/articles/s41...

Are you a future black leader in cancer? Come join @mirazrahman.bsky.social and my labs @qmbci.bsky.social @kingscollegelondon.bsky.social to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details www.colcc.ac.uk/2026-blic-ph...

2026 BLiC PhD Project Soliman

Targeting a cell cycle vulnerability in TP53 mutant cancers Primary supervisor: Tanya Soliman, Queen Mary University of London Secondary supervisor: Miraz Rahman, King's College London Project To ...

colcc.ac.uk

Cancer Research UK City of London Centre@cruk-cityoflondon.bsky.social · 10mo ago

Are you interested in doing a #PhD in #cancerresearch? 🧪👩🏿‍🔬🧫🦠🔬 Do you want to develop new #biotherapeutics? Are you of black heritage? Applications for our fully funded 4-year BLiC PhD programme starting in Autumn 2026 are open now! bit.ly/485QAga #uclcancer #QMBCI #KCLcancer_pharm #KCL #TheCrick

Apply to join our lab for a very cool PhD project studying radiation therapy, chromosomal instability, DNA repair and cancer evolution!

Mcclelland lab@mcclellandlab.bsky.social · 10mo ago

We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...

Ultimate dream - scientific work leading to major impact on people’s lives, the researchers and Drs involved must be over the moon to treat such a difficult and horrendous disease www.bbc.co.uk/news/article...

Huntington's disease successfully treated for first time

One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

bbc.co.uk

We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs. Please share with colleagues who may benefit! ericjoycelab.com/oligopaint-f...

Oligopaint Probe Requests

In an effort to make Oligopaint FISH probes more broadly available to the research community, we offer DNA and RNA FISH probe design, synthesis, and generation. By dedicating a full-time staff memb…

ericjoycelab.com

@mcclellandlab.bsky.social hosted Prof Raksawan Deenonpoe from Thailand so she could collaborate with @mollyguscott.bsky.social & I to look for evidence of chromosomal instability in cholangiocarcinoma. Our work is now published in Journal of Pathology.

About time academics showed some moral fibre www.uu.nl/en/news/utre...

Utrecht University will not enter into any new collaborations with Israeli organizations until further notice

Utrecht University has decided to suspend all new collaborations with Israeli organizations until a committee can provide guidance on potential partners.

uu.nl

Ever more depraved , like real world Squid Games, they should be relegated to pariah status www.bbc.co.uk/news/article...

Gaza aid site offered a 'women only' day. It didn't stop the killing

Families say mothers Mary Sheikh al-Eid and Khadija Abu Anza were shot while seeking aid from GHF station in southern Gaza.

bbc.co.uk

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...

Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells

In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...

biorxiv.org

We're very proud that our recent PhD graduate (and now postdoc) Rosie Wilkins' study on RNase H2 overexpression in human cells has been published in Oncogene. www.nature.com/articles/s41...

Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress - Oncogene

Oncogene - Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress

nature.com

It’s starting 😞 12 children, 21 adults starved to death by Israel. www.bbc.co.uk/news/article...

Gaza health ministry says 33 people died from malnutrition in 48 hours

Fifteen deaths have been reported over the past day, the Hamas-run ministry says, as the UN warns of

bbc.co.uk

Great talk by @susanagodinho.bsky.social at London Cell Club today

Two years ago, being accused of bombing a hospital was met with horror and denials. Now, bombing children is met with a shrug www.bbc.co.uk/news/article...

Gaza officials say children killed in strike as Israeli military admits 'error'

Six children waiting for water are among those killed in an Israeli air strike, emergency service officials say.

bbc.co.uk

Interested in population genetics of cancer? If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!

Benjamin Werner@benjaminwerner.bsky.social · last yr.

Very happy that @alexsteinresearch.bsky.social manuscript on the patterns of genetic heterogeneity before and after treatment is out now: academic.oup.com/genetics/adv... We build on and expand the population genetics theory of gITH. Very worth a read if you are interested in somatic evolution.

We have a new study out - Distinct functions of PAXX and MRI during chromosomal end joining: iScience www.cell.com/iscience/ful...

Distinct functions of PAXX and MRI during chromosomal end joining

A key step of Canonical-Nonhomologous End Joining is synapsis of DNA double strand break (DSB) ends, which appears to be mediated by both the DNA-PKcs dimer and XLF homodimer. We have examined this pr...

cell.com

Delighted to share that the results of my main postdoc project are now published in @nature.com 🔗 doi.org/10.1038/s415...

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

doi.org

Hi all, my team institut-curie.org/team/fachine... @institutcurie.bsky.social is looking for a Bioinformatician. You can find more details about the position here: euraxess.ec.europa.eu/jobs/344508 Is anyone looking for a job in the lovely Paris?