The domestic cat may be a far more recent arrival to Europe than previously thought, according to a 2025 Science study. The findings offer new insight into one of humanity’s most enigmatic animal companions. https://scim.ag/44kov1S #InternationalCatDay

Nature research paper: An expanded codebook of human transcription factor DNA-binding specificity go.nature.com/4wMUZ15

An expanded codebook of human transcription factor DNA-binding specificity - Nature

Results from a panel of assays that analyse different aspects of DNA sequence specificity reveal more than 100 new motifs to aid the characterization of putative human transcription factors.

go.nature.com

Very happy to see this story finally out in @natbiotech.nature.com: www.nature.com/articles/s41... Fantastic collaboration with @lancasterlab.bsky.social on how to identify and ‘fix’ differentiation-compromised human pluripotent stem cells. @babrahaminst.bsky.social @mrclmb.ac.uk 🧵 below

Reversible epiblast regionalization determines differentiation potential of human pluripotent stem cells - Nature Biotechnology

The differentiation variability of human pluripotent stem cell lines is diagnosed and corrected.

nature.com

Finally understand what COMPASS means! www.biorxiv.org/content/10.6...

COMPASS: Component-Wise Inference of Shared and Gene-Specific Perturbation Response

Predicting how a genetic perturbation reshapes a cell's transcriptome is a central goal of computational biology. Previous studies report that the mean response across training perturbations rivals sp...

biorxiv.org

(1/n) Excited to share close collab w @bloodgenes.bsky.social led by Varshini & Chun-jie et al How to induce expression of key genes while silencing much of the genome during Erythropoiesis? A: Matchmaker CREs load cohesin near key genes to promote looping & exp: www.biorxiv.org/content/10.6...

RESEARCH COMMUNICATION: The Bcl11–Cxxc1 axis regulates stage-specific chromatin accessibility during lymphocyte development By Okuyama et al., and Ichiro Taniuchi ➡️ https://genesdev.cshlp.org/content/40/15-16/1214.abstract RIKEN #transcriptionfactor #lymphocyte #Tcell #Bcell #chromatin

A really cool preprint from Joanna Wysocka's lab showing that housekeeping genes use distal enhancers as dosage buffers against TF fluctuations, but only during critical cell fate transitions. Makes so much sense! www.biorxiv.org/content/10.6...

Enhancer buffering protects dosage-sensitive housekeeping genes during vulnerable developmental transitions

Housekeeping genes maintain robust expression across cell types despite dynamic transcription factor fluctuations, yet their haploinsufficiency is associated with many tissue-specific developmental di...

biorxiv.org

Very happy to share that our story is now published in @natplants! 🥂 Check it out here: nature.com/articles/s41... A study by @UGrenobleAlpes @LPCV_Grenoble @IBS_Grenoble made possible thru significant collaboration with @institut_curie @iGred @uni_regensburg. 1000 thanks to all!

The dual trxG/PcG protein ULTRAPETALA1 modulates H3K27me3 and directly enhances POLYCOMB REPRESSIVE COMPLEX 2 activity for fine-tuned reproductive transitions - Nature Plants

This study reports a bivalent factor, ULTRAPETALA1, that can counteract as well as promote PRC2 activity at hundreds of developmental genes in Arabidopsis thaliana. The pro-PRC2 activity of ULTRAPETAL...

nature.com

A resource defining the early stages of vertebrate forelimb development This Research Highlight showcases work by Vighnesh Ghatpande, Can Cenik, Steve Vokes and colleagues. journals.biologists.com/dev/article/...

Get your calendars, because the new 2027 EMBL Annual Poster has arrived: s.embl.org/2027-poster Whether you'd like to enhance your skills in a practical course or engage with the latest research at one of our conferences, we've got you covered. See you at EMBL in 2027! 🙌 #LifeSciences #EMBL

☕Zhou, Wang et al. dissect the role of #PRC2 in early #embryogenesis through inducible degradation of EED, a core PRC2 subunit, and report that PRC2 is required for proper maternal-to-zygotic transition and promotes #epiblast specification. 👉https://rdcu.be/fwFjr www.nature.com/articles/s41...

Decoding stage-specific functions of PRC2 in early embryogenesis uncovers roles in preimplantation development and primordial germ cell fate - Nature Cell Biology

Zhou, Wang et al. dissect the role of PRC2 in early embryogenesis through inducible degradation of EED, a core PRC2 subunit, and report that PRC2 is required for proper maternal-to-zygotic transition ...

nature.com

📢PUBLISHED @natgenet.nature.com 📰Pioneer transcription factors direct tissue-specific cohesin chromatin entry and three-dimensional genome organization. By Song Wang, Haiyang Guo and colleagues. ⬇️ www.nature.com/articles/s41...

Pioneer transcription factors direct tissue-specific cohesin chromatin entry and three-dimensional genome organization - Nature Genetics

Analyses in prostate cancer cell lines show that FOXA1 mediates tissue-specific recruitment of NIPBL to chromatin to orchestrate three-dimensional genome organization, acting in concert with ETS1 and ...

nature.com

Preprint alert! 🚨 We are very excited to share our new manuscript on Bohring-Opitz syndrome, a devastating rare monogenic disorder driven by truncating variants in ASXL1. This project was led by PhD student Emma Doyle, one of the OG Conway lab members 💪. 1/6 www.biorxiv.org/content/10.6...

Divergent Pathogenic PR-DUB Complex Variants Converge Functionally Via PRC2 Displacement From Chromatin

The PR-DUB complex is responsible for erasing the repressive histone modification, H2AK119ub1. ASXL1-3 proteins are mutually exclusive catalytic partners of BAP1 in the PR-DUB complex. Somatic heteroz...

biorxiv.org

We know little about proteins required for long-range compartment 3D interactions, but this @kyleeagen.bsky.social lab preprint shows that NSD3 can make Mb-scale long-range compartment-like interactions: www.biorxiv.org/content/10.6...

4D Nucleome special issue of Science, featuring our paper "Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor", led by Zoe Grant in my lab and Zhuzhen Kuang in Katie Pollard's lab @gladstoneinst.bsky.social www.science.org/toc/science/...

Masahiro and I were fortunate to contribute some RCMC analyses to this beautiful paper from Koska and Wysocka that comprehensively dissects the determinants of promoter competition: www.nature.com/articles/s41...

Tribute to Gail Martin www.sciencedirect.com/science/arti... Discoverer of #EScells whose curiosity went beyond cells, genes / embryos. Good for younger generations to learn @ these giants. NB. Unfathomable why she was overlooked for a Nobel Prize, though this says more @ prizes than @ her.

Now online! Robust regulatory interplay of enhancers, facilitators, and promoters in a native chromatin context

Robust regulatory interplay of enhancers, facilitators, and promoters in a native chromatin context

Using an in situ genome-rewriting platform, Zhou et al. demonstrate that precise transcriptional regulation of the NMU promoter is governed by a 3D regulatory hub comprising a core retroviral LTR enhancer, a decoy LTR promoter, and activity-boosting “facilitator” elements.

dlvr.it

MIT Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86 news.mit.edu/2026/mit-pro... #neuroscience

MIT Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86

Susumu Tonegawa, a renowned MIT professor of biology and neuroscience and a Nobel laureate, has died at the age of 86. His discovery of how the immune system generates many different antibodies earned...

news.mit.edu

In memory of Pierre Chambon (1931–2026): a visionary pioneer of modern molecular biology by Hinrich Gronemeyer in @embojournal.org link.springer.com/article/10.1...

In memory of Pierre Chambon (1931–2026): a visionary pioneer of modern molecular biology - The EMBO Journal

The EMBO Journal -

link.springer.com

An encyclopedia of enhancer-gene regulatory interactions — online today! nature.com/articles/s4158… Now with an improved model, expanded maps across 1400+ biosamples, larger validation CRISPR datasets, and guidance on applying the model 1/

Andreas Gschwind@argschwind.bsky.social · 4w ago

Thrilled to share that our ENCODE enhancer–gene mapping paper is now out in Nature! An encyclopedia of human enhancer–gene regulatory interactions: www.nature.com/articles/s41... Thread 👇 1/

Thrilled to share that our ENCODE enhancer–gene mapping paper is now out in Nature! An encyclopedia of human enhancer–gene regulatory interactions: www.nature.com/articles/s41... Thread 👇 1/

An encyclopedia of human enhancer–gene regulatory interactions - Nature

An encyclopedia of more than 92 million enhancer–gene regulatory interactions created as part of the ENCODE4 project provides a valuable resource for future studies of gene regulation and human geneti...

nature.com

Our preprint is now out in @natgenet.nature.com ! doi.org/10.1038/s415... We measured Sox2 promoter bursting dynamics with the SCR enhancer positioned at different distances within a genomic locus devoid of confounding effects in mESC: Main findings in the 🧵 below:

Enhancer control of promoter activity and variability via frequency modulation of clustered transcriptional bursts - Nature Genetics

Tünnermann et al. use live-cell imaging to study promoter activity under the control of an enhancer inserted at different genomic distances. RNA production from the promoter occurs in clusters of tran...

doi.org

Luca Giorgetti lab @FMI@lucagiorgetti.bsky.social · last yr.

Celebrating 10 years of our lab with a new preprint: www.biorxiv.org/content/10.1... How does enhancer location within a TAD control transcriptional bursts from a cognate promoter? Experiments by Jana Tünnermann and modelling by Gregory Roth

@mileshuseyin.bsky.social and the lab have put together a comprehensive protocol for genome-wide Micro-C and for Region-Capture Micro-C in @natprot.nature.com : www.nature.com/articles/s41... See also the GitHub for a user-friendly end-to-end computational pipeline: github.com/ahansenlab/M...

Nature Protocols@natprot.nature.com · 4w ago

New Article! Mapping 3D genome organization at nucleosome-scale with Micro-C and Region Capture Micro-C (RCMC)

Preprints don’t change much after peer review — and are rarely retracted. go.nature.com/4pebHmM

Think preprints are unreliable? Analysis of 70,000 studies might change your mind

Preprints don’t change much after peer review — and are rarely retracted.

go.nature.com

Amazing new method for live-cell imaging of RNA molecules developed by Adam in the Brockdorff lab! Worth having a look at!

bioRxivpreprint@biorxivpreprint.bsky.social · last mo.

Nuclear-BRITE: an enhanced MS2 system for live-cell imaging of nuclear RNAs https://www.biorxiv.org/content/10.64898/2026.07.07.736975v1

Now's your chance to collect citeable 'at a glance' posters from @dev-journal.bsky.social & @dmmjournal.bsky.social at #ISSCR2026, including 'Stem cell-based models of early human development' by @liliulab.bsky.social and @jun-wu-lab.bsky.social l. Visit @biologists.bsky.social booth #1005.

Educational web app that explains the principles of microscopy and related topics. Made for my class at UTokyo, where I am teaching the Physics of Microscopy this semester to Physics undergrads. dbkk.github.io/optics-phys-...

OpticsPhysLab

An interactive browser lab for learning optics and microscopy.

dbkk.github.io

NuRD-enabled CTCF-TET crosstalk orchestrates epigenome reprogramming and genome architecture

NuRD-enabled CTCF-TET crosstalk orchestrates epigenome reprogramming and genome architecture

CTCF binding loci are generally hypomethylated at CpG, yet how this epigenetic state is established remains unclear. Sun et al. demonstrate that the NuRD complex stabilizes CTCF on chromatin, facilitates the recruitment of TET dioxygenases to sustain local DNA hypomethylation, and is essential for genome architecture and lineage commitment.

dlvr.it

📢 Event tip: Katsuhiko Hayashi from the University of Osaka joins the MPI-IE Lecture Series – hosted by @denbobalab.bsky.social. Hayashi is a leading pioneer of in vitro gametogenesis (IVG) – a revolutionary technique that creates functional gametes from stem cells & enabling bipaternal conception.