Excited to announce the publication of a special issue on "Glia and non-neuronal cells in Huntington’s disease" that I co-edited with Dr. Asa Petersen in the Journal of Huntington's Disease (Volume 14, Issue 3)! journals.sagepub.com/toc/huna/14/3 1/3

Can we identify biomarkers responsive to mHTT lowering? In this new study, we investigated 💧 #CSF and ☢️ #PET biomarkers that could be used non-invasively to track 📈 the temporal response to #mHTT modulation in mice 🐭. #openaccess article: 👉 lnkd.in/eqTirauF

A new study has ranked Canada 3rd on a list of the top countries with social purpose, seen as being “the most progressive and inclusive” countries in the world. Denmark and Sweden occupy the top 2 spots on the list, while Norway and New Zealand round out the top 5. Via @cultmtl.bsky.social

Canada named among top countries with social purpose

A study by U.S. News & World Report has ranked Canada third on a list of the top countries with social purpose.

cultmtl.com

Changes to MSc, PhD and postdoc funding programs from 🇨🇦 tri councils. Harmonization across councils, more awards, and new eligibility for international PhD and postdoc applicants!

From #OUP 's #DATABASE journal | VarGuideAtlas: a repository of variant interpretation guidelines | #Bioinformatics #Genomics 🧬 🖥️ 🧪 🔓 ⬇️ academic.oup.com/database/art...

VarGuideAtlas: a repository of variant interpretation guidelines

Abstract. Variant interpretation guidelines guide the process of determining the role of DNA variants in patients’ health. Currently, hundreds of guideline

academic.oup.com

Come be my colleague at UBC! A great place to work w/amazing students, a beautiful campus, and…maybe one or two other perks 🇨🇦

Dr Karen Pinder 🇨🇦 🔬@drkarenpinder.bsky.social · 2y ago

We are hiring our next Department Head. If interested, you will be joining a great team of committed researchers and teachers. 👇 www.med.ubc.ca/careers/admi...

Today we report in 𝘾𝙚𝙡𝙡 𝙎𝙩𝙚𝙢 𝘾𝙚𝙡𝙡 a systematic approach to generate neural #organoids resembling various domains of the neural axis Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS

Women tend to age better cognitively than men, but why? This cool new study finds aging reactivates genes on the inactive X chromosome in the female hippocampus. This shift could contribute to cognitive resilience, with the myelin gene Plp1 playing a major role. www.science.org/doi/10.1126/...

Aging activates escape of the silent X chromosome in the female mouse hippocampus

Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.

science.org

Bioinformatics Job Opportunity Research Associate / Staff Scientist Vancouver Canada Join the Silent Genomes Project to provide an outstanding genetic variation database for Indigenous peoples of Canada to improve rare disease diagnosis tinyurl.com/bm4ptux3 Priority to Canadians Please repost

Research Associate

Academic Job Category Faculty Non Bargaining Job Title Research Associate Department Wasserman Laboratory | Department of Medical Genetics | Faculty of Medicine (Wyeth Wasserman) Posting End Date Febr...

tinyurl.com

Looking for a postdoc with expertise in genetics and neuroscience. Experience in Drosophila a plus. Get in touch! www.uwo.ca/research/fun...

Western Postdoctoral Fellowship Program

Western University, in vibrant London, Ontario, delivers an academic and student experience second to none.

uwo.ca

This large multi-omic study links tandem repeat (TR) variations to gene regulation in the human brain. We’ve know for sometime that TRs are not just genomic noise (TRs cause HD, FXS, SCAs, ALS/FTD to name a few), but ~18k TRs as potential causal variants is still a shock. doi.org/10.1038/s415...

Multi-omic quantitative trait loci link tandem repeat size variation to gene regulation in human brain - Nature Genetics

Mapping of multi-omic molecular quantitative trait loci associated with tandem repeat size variation in up to 4,412 human brain samples from 1,597 donors offers insights into how these variants affect...

doi.org

UBC’s Dept of Medical Genetics is hiring a tenure-track Assistant Professor at the Life Sciences Institute. If you’re interested in joining a strong research community in Vancouver, check out the job posting: medgen.med.ubc.ca/assistant-pr... Please share with anyone who might be a great fit!

Good morning! Day 1 of #CHDI2025 is kicking of NOW! Get ready to follow along for some exciting Huntington’s disease research over the next 3 days.

Job available for Full Professor Tier 1 Canada Research Chair (CRC) - Indigenous Health and Well-Being at the Faculty of Health Science, Simon Fraser University (RT 🙏🏼 please): www.sfu.ca/vpacademic/a...

Canada Research Chair - Indigenous Health and Well-Being

sfu.ca

My group would take at least 2 people interested in neurodegeneration as post docs bsky.app/profile/maxi...

Marco A. Maximo Prado@maximoprado.bsky.social · 2y ago

We are looking for motivated post docs. Projects on Alzheimer’s and Synucleinopathy. New mouse models, combined lightsheet/15.2T MRI and high throughput cognitive testing using touchscreens. Perfect for a recent graduate in Neurosciences or related field. Come work with us in 🇨🇦 👊😀🧪 please share.

The HD community has come to Bluesky!

Mahmoud Pouladi@pouladilab.bsky.social · 2y ago

Made a starter pack of the Huntington disease researchers/orgs I can find on Bluesky. If you’re an HD researcher and want to be added, reply or DM. go.bsky.app/UM9WCpA

www.ubc.ca/campus-notif... in-person classes at ubc Vancouver are cancelled tomorrow. I only found out due to a message from a colleague in another department forwarded to me. You can cancel outright or move to online.

New opportunity posted: Principal Investigator in neurodevelopment/Assistant Professor – CHU Sainte-Justine Azrieli Research Centre, Université de Montréal can-acn.org/principal-in... #neurojobs @CRA_CHUSJ

Made a starter pack of the Huntington disease researchers/orgs I can find on Bluesky. If you’re an HD researcher and want to be added, reply or DM. go.bsky.app/UM9WCpA

Come be my boss! We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children. Toronto, Canada (the deadline has been extended from Jan 31) Please Re-post. jobs.sciencecareers.org/job/667223/p...

Program Head - Molecular Medicine, The Hospital for Sick Children Research Institute - Toronto (City), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 667223

Provide leadership and mentorship to members of the Molecular Medicine Program and influence the scientific direction of the Research Institute

jobs.sciencecareers.org

This looks useful for Canadian academics https://universityaffairs.ca/career-advice/how-to-write-a-narrative-cv/

How to write a narrative CV - University Affairs

This document should strongly demonstrate your capability as well as the feasibility of your proposed work.

universityaffairs.ca

Beware! AAV libraries prone to length & homology dependent chimerism! Our latest preprint, from the brilliant @jblalanne.bsky.social‬, was a true surprise as related phenomena are textbook for lentivirus (highly relevant to HIV & Perturb-seq) yet to our reading not known for AAV tinyurl.com/5amc562a

Extensive length and homology dependent chimerism in pool-packaged AAV libraries

Adeno-associated viruses (AAVs) have emerged as the foremost gene therapy delivery vehicles due to their versatility, durability, and safety profile. Here we demonstrate extensive chimerism, manifesti...

tinyurl.com

@jblalanne.bsky.social · 2y ago

Brief PSA for the functional genomics community: if you are profiling complex libraries with >1 internal components (e.g., enhancer+barcodes in MPRAs) delivered via AAVs, be aware that there might be substantial unlinking within your libraries if you packaged as a pool! doi.org/10.1101/2025...

Appreciate this generous write up on our recent preprint! www.thetransmitter.org/spectrum/hai...

Many autism-linked proteins influence hair-like cilia on human brain cells

The finding may help explain autism’s association with multiple co-occurring conditions that involve cilia defects.

thetransmitter.org

Come join us @umontreal.ca - We're looking to recruit a Professor in the field of neurobiology, with a focus on linking neurodevelopment to neural circuit function and dysfunction. #neuroskyence #neuroscience 🧪 See ad below - www.fens.org/careers/job-...

Protein quality control is a tug-of-war between degradation machinery and chaperones that promote folding. Thrilled to see our latest manuscript is now published! 👇 Follow 🧵 for quick summary journals.biologists.com/jcs/article-...

This is pretty wild! Electric spoon that enhances the perception of saltiness in food! techcrunch.com/2025/01/05/k...

Kirin offers a taste of its electric salt spoon at CES 2025 | TechCrunch

On the first night of CES 2025, Kirin Holdings, a Japanese company known for its beer and beverages, showed off its new electronic spoon that makes your

techcrunch.com

My first #job ad here! We are looking for a res assistant in #bioinformatics to analyse #single-cell and #spatial #transcriptomics data in #skin inflammation. Job based at King's College London, with opportunity to spend time at @ubcmedicine.bsky.social in beautiful Vancouver tinyurl.com/4xd9n5n7

Research Assistant in Bioinformatics at King's College London

Recruiting now: Research Assistant in Bioinformatics on jobs.ac.uk. Click for details and explore more academic job opportunities on the top job board

tinyurl.com

Terrific! Paywalls are disappearing! No more 12 month embargo between when NIH funded work appears in a journal and when it becomes accessible to all (as of December 2025). www.nih.gov/about-nih/wh...

Scientist position at The Hospital for Sick Children in Toronto. We are looking for neuroscientists with interests in the molecular and cellular bases of cognition. The position is open-rank, and the successful candidate will also be appointed at U Toronto. Deadline is Feb 15th. Come join us!