Three articles in @sciimmunology.bsky.social describe the molecular mechanisms by which pyrin is hyperactivated, where CDC42 is a binding partner of the pyrin B30.2 domain www.science.org/doi/10.1126/...

#ImmunometabolismPower! Excited to share our review @cp-cellchembiol.bsky.social with super-talented @tristramryan.bsky.social about the activity of immunometabolites of the #TCA #Krebs cycle working as metabolic damage-associated molecular patterns #metaDAMPs in health & disease!

Metabolic danger signals: TCA cycle metabolites regulate immunity and disease

Mitochondrial tricarboxylic acid (TCA) cycle metabolites have emerged as critical regulators of immunity and inflammation beyond their canonical metab…

sciencedirect.com

Gasdermin D-mediated delivery of caspase inhibitors to suppress pyroptosis @nature.com www.nature.com/articles/s41...

A new PAMP, a new innate immunity principle and a new preclinical application. I am so pleased to share our study on STING activation mechanisms in health and disease. Led by the fantastic Stephanie Ragland, follow the link below for a summary of all we learned. www.cell.com/immunity/ful...

Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING

Innate immune recognition of bacteria is thought to center on cell-surface or endosomal pattern recognition receptors such as TLRs. Ragland et al. identify an intraphagosomal cyclic dinucleotide (CDN)...

cell.com

Excited to share a highlight that Birgit Sawitzki and I wrote about a recent preprint on fine-tuning macrophage polarization using synthetic cytokine receptors from the @sciencekyle.bsky.social Lab! @preprintclub.bsky.social

📣Seeking highly motivated and creative Postdoctoral Fellow Build on our recent Nature 2026 story on caspase-5. Exciting projects linking innate immunity, regeneration, IBD, & cancer. DM or email: blanderadmin@med.cornell.edu. CV, cover letter, 3 refs. #Postdoc #Immunology #IBD #CancerBiology #Hiring

“The entire National Science Foundation budget is less than what we spent in the first week of the war with Iran. The National Institutes of Health,… accounts for a fraction of 1 percent of all federal spending” www.nytimes.com/2026/06/20/o...

Opinion | The Science That Turned Lizard Venom Into GLP-1s Is Under Attack

nytimes.com

New NIH Request for Information regarding capping the number of Research Project Grants allowed per investigator. grants.nih.gov/grants/guide... Open for comments until August 3rd, 2026

A 14-protein plasma signature identifies individuals benefiting from anti-IL-1β-based lung cancer risk reduction @cellcellpress.bsky.social @charlesswanton.bsky.social @clareweeden.bsky.social @wehi-research.bsky.social www.cell.com/cell/fulltex... @crick.ac.uk

Interested in autoinflammatory diseases? Read our review on Variants of Uncertain Significance (VUS) in @natrevrheum.nature.com with @alessandracarbone.bsky.social, Guilaine Boursier & Sinisa Savic. How to decode VUS through genetic, in silico, functional approaches and clinic! rdcu.be/fkOJM

A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines www.nature.com/articles/s41... @lozanzi.bsky.social @harvardmed.bsky.social @natimmunol.nature.com

#InterferonPower #InflammasomePower! Thrilled for our 💥#NewPaper💥 @natimmunol.nature.com spearheaded by Kautilya Jena showing that our #fungal adjuvant #Mannadjuvant prolongs & potentiates protection of mRNA vaccines via #IL1b & #IFNs, broadening it to new variants & overcoming antigenic imprinting!

A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines

Nature Immunology - Jena, Qu et al. show that mannadjuvant, a formulation of fungal mannan and aluminum hydroxide, increases the magnitude, durability and breadth of the response elicited by...

rdcu.be

I'm so delighted to share that I have been awarded a K99/R00 from NIH/NIAID to study the priming and activation mechanisms of NLRP3 against inflammatory diseases 🥳 !! This would never have been possible without the amazing mentoring and support from Ivan @lozanzi.bsky.social !!

#EveryCellIsAnImmuneCell! 💥#NewPaperAlert💥 Excited to share our latest review with @agharrison.bsky.social about molecular, cellular & #spatial control of the immune response regulated by #stromal, #innate, & #adaptive immune cells in the lymph node! Free link👉 www.sciencedirect.com/science/arti...

Won’t you be my neighbor? Control of the immune response by stromal and immune cell microenvironments within the lymph node

Efficacious immune responses require the coordinated encounter of rare antigen-specific adaptive lymphocytes with their cognate innate antigen-present…

sciencedirect.com

Please check out our latest publication where we find that caspase-3, which mediates what is thought to be an immunologically silent form of cell death is important for protecting against bacterial infections. Congrats to the whole team for making this possible. journals.plos.org/plospathogen...

Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages

Author summary The immune system uses specialized sensors called inflammasomes to detect infection and trigger protective responses. These responses are carried out by enzymes known as caspases, which...

journals.plos.org

I will start my own research group at @ipblncsic.bsky.social, and I am already available to support fellowship applications!! A dream come true thanks to my mentors' continuous support: J-M Ruysschaert, @ppelegrin.bsky.social, Kate @inflammasomelab.bsky.social, @clarebryant.bsky.social Thank you!

I’m stoked to share my postdoc work with @sunnyshinlab.bsky.social, a collaborative effort with @metabailism.bsky.social & Brian Goldspiel, aided by many valued collaborators: Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly. Some big takeaways:

bioRxiv Immunology@biorxiv-immuno.bsky.social · 7mo ago

Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly https://www.biorxiv.org/content/10.64898/2026.01.16.699988v1

📣 Job opening in our lab! We're looking for a technician with experience in murine models. More details about the job description here 👇 www.linkedin.com/jobs/view/4353643662/

Bronnec, @cinflammasome.bsky.social et al. @ciri-lyon.bsky.social developed SpeckSeq to evaluate the pathogenicity of 228 MEFV variants. SpeckSeq leads to a revised classification of MEFV variants, new diagnoses, & novel insights on pyrin structure–function relationship. rupress.org/jem/article/...

November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online. www.embopress.org/doi/full/10....

NINJ1 blocks HSV-1 entry into macrophages to impact viral replication and immunity | EMBO reports

imageimageNINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro inflammatory cytokines downstream of infection. Mouse macrophages lacking NINJ1 are more permissive to HSV-1 ...

embopress.org

www.nature.com/articles/s41... Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy - Nature

Acetyl-coenzyme A functions as a non-canonical signal to trigger mitophagy, and the acetyl-coenzyme A–NLRX1 axis underlies the KRAS-inhibitor-induced mitophagy response and promotes drug resistan...

nature.com

#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇

#ThatIsTheQuestion Post-translational modifications of NLRP3: to prime or not to prime? Thrilled to have had the opportunity to write this review with @lozanzi.bsky.social 🤩! We discuss how PTMs coordinate during priming to control NLRP3 stability, location & partners. tinyurl.com/35dy5rcc

Post-translational modifications of NLRP3: to prime or not to prime?

The NLRP3 inflammasome plays a central role in host defense against microbial infections but also contributes to inflammatory diseases. Functioning of…

tinyurl.com

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.

Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...

biorxiv.org

#SpookyInflammasome 🎃 With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis. ... more to come on the priming !

Ivan Zanoni@lozanzi.bsky.social · 9mo ago

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature

The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...

doi.org

#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium) Register now: bit.ly/4iXGqjw

💡Our webinars are back! Don’t miss our session on macrophage metabolism this September 18th at 1:00 PM CET. Stoyan Ivanov (Research Director; C3M, Nice) and Malvina Seradj (Postdoc; Institute of Cancer Research, London). 🔗 Register here: tinyurl.com/2feve67c

#InterferonPower Immensely honored and excited to share our new review on all things Interferons out now in @cp-cell.bsky.social. Grateful to the brilliant & inspiring @lozanzi.bsky.social for the chance to contribute! Check it out! authors.elsevier.com/c/1leKGL7PXu...

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...