Today at @humantechnopole.bsky.social we treated ourselves to a real deli! Huge thanks to @olibclarke.bsky.social for spending the day with us + value time in the labs + great talk 🙏 (apparently Oli is immune to to jet lag 😂)

It has been an amazing gathering of old and new friends. We shared tips but also addresses ☺️ One thing is sure: this workshop series is going strong.

Instruct-ERIC@instruct-eric.bsky.social · 5mo ago

The Instruct Best Practices in Cryo-EM Workshop is an opportunity for facility staff and technicians to exchange experiences and the latest developments EM - thank you to all participants for a great meeting so far in Milan! @thermofishersci.bsky.social #IMAGINE @humantechnopole.bsky.social

📢 First preprint from the Casañal Lab! Excited to share our work on human NSUN2, done together with the brilliant @ecleroy.bsky.social. Using #CryoEM, we capture the dramatic structural rearrangement of tRNA as it flips a cytidine into the NSUN2 catalytic pocket for m⁵C modification. Take a look👇

Elodie Carmen Leroy@ecleroy.bsky.social · 5mo ago

🚨 Preprint alert! We solved the structure of human NSUN2 bound to Asp tRNA, revealing how it installs m⁵C and recognizes RNAs #CryoEM #RNABiology A collab between Casañal & Gullerova labs, with @miclass.bsky.social and me working side by side as co-first authors 🔗 doi.org/10.64898/202... (0/7🧵)

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit www.nexperion.net/semcm2026

Time to get signed up for the Symposium on Structural Proteomics! This time at @humantechnopole.bsky.social in Milan 6th-8th October Full speaker lineup announced. Thanks to @thermofishersci.bsky.social @brukercorporation.bsky.social, Affipro and MSVision for support Info ssp2025.squarespace.com

🧬 We're excited to host the 13th Symposium on Structural #Proteomics at HT in Milan on 6–8 Oct 25! Join this international meeting with talks on protein structure and interactions by crosslinking MS, HDX-MS, native MS, chemoproteomics & more 👉 ssp2025.squarespace.com ▶️ @ssp2025.bsky.social

Pit stop for our Aquilos dewar got even easier with the 3D printed funnel from friendly Zurich team (shout-out to blueskyless Piotr Szwedziak)!

🚀 We’ve just received some user feedback for the National Facility for Structural Biology and I couldn’t be more grateful and excited!

🚨 We're Hiring! We're looking for a passionate and skilled EM Specialist to join our team! 📅 Application Deadline: July 9th, 2025 🔗 Learn more and apply here: careers.humantechnopole.it/o/electron-m...

Human Technopole - Electron Microscopy (EM) Specialist

APPLICATION CLOSING DATE: July 9th 2025About the InstituteHuman Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian government, with the aim o

careers.humantechnopole.it

Thrilled that Sir Mel Greaves will be our next speaker for the @humantechnopole.bsky.social External Seminar Series on June 5th. Thanks to Andrea Sottoriva for hosting! For external people wanting to join, please see: forms.office.com/e/dtD3NcRKMN.

🚀 Second Round of National Facility Access is Underway! Application Deadline for next round is 31-05-2025! Get in touch if you need any help designing your experiments.

"Excited" to commission the iFLM microscope on our Aquilos 2 @humantechnopole.bsky.social Bringing some colors in an otherwise grey landscape 😆 This will greatly boost our CLEM workflows!

Great to have @martinpacesa.bsky.social as invited speaker to our weekly Structural Biology Colloquia. Such a solid, functional and impactful workflow 🤩. Thanks a lot for coming!

Excited to see the first batch of biomass safely delivered from our National Facility for Structural Biology @humantechnopole.bsky.social to Filippo Acconcia of Università Roma Tre. A big thank you to our stellar Biomass Unit, onward to more milestones!

A real milestone for the local community, today we celebrate the beginning of service provision by @humantechnopole.bsky.social National Facility for Structural Biology. Lucky to have a smiling @luigiscietti.bsky.social (in pic with our Gaetano D'Urso) from IEO as first user to the Cryo-EM Unit.

More than 1'800 tomograms available for the community. Towards visual proteomics using our favorite organism Chlamy! Check out the preprint: www.biorxiv.org/content/10.1... Find it on EMPIAR (11830) and fully annotated on the CZI data portal: cryoetdataportal.czscience.com #TeamTomo

Towards community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii

In situ cryo-electron tomography (cryo-ET) has emerged as the method of choice to investigate structures of biomolecules in their native context. However, challenges remain in the efficient production...

biorxiv.org

Shoutout to Simona Sorrentino, our incredible Cryo-EM Specialist, whose dedication to outreach and communication is making a real impact...also on national TV 🤩

Absolute delight living with these extraordinary people! Russian deli for the National Facility for Structural Biology dinner 🤤

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.

Cmon…Structural Proteomics post in a StruBio National Facility, working WITH Cryo-EM, Biophysics, Biomass and Single-Molecule. Mmmh, did I mention this person will also work with Genomics Facility?!? Too easy to advertise. 🤭

Sebastiano Pasqualato@spasqualato.bsky.social · 2y ago

JOB ALERT!!! The National Facility for Structural Biology at @humantechnopole.bsky.social is HIRING!! BlueSky-less Andrea Graziadei is looking for a technician to join his Unit and push #structuralproteomics to new, uncharted territories!! 1/3

Great talk today at our weekly @humantechnopole.bsky.social Structural Biology Colloquia!!! @spasqualato.bsky.social and Natasha Danilenko are outstanding pillars of Biophysics Unit.

Highly recommended Group Leader!!! Cosy city and great field.

Ferdos Abid Ali@abidalilab.bsky.social · 2y ago

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪

👇 Did you know one can use pulsed lasers not only to increase contrast in #cryoEM images, but also to reduce preferred particle orientation, by melting & re-vitrifying samples in a controlled way? ❄️🔬

cryoEM papers@cryoempapers.bsky.social · 2y ago

Laser Flash Melting Cryo-EM Samples to Overcome Preferred Orientation biorxiv.org/cgi/content/short/2024.11.21.624652v1

Absolute delight to have Kasia Tyck @biophysk.bsky.social to show us the wonders of single molecule! Pulling a single protein and measure 1nm changes is 🤯. I also love remote seminars, you can get experts from anywhere in less time. Impact-less and impactful at the same time.

I kind of forgot how to announce Feeds, but here goes For an all-in-one CryoEM Feed: #CryoEM, #CryoET, #TeamTomo all-in-one feed that curates posts from the last 7 days containing the various cryoEM and cryoET related hashtags and keywords. bsky.app/profile/did:...

The next GRC on volume Electron Microscopy is coming soon. Don't miss this opportunity and apply now as the number of seats is limited. #volumeEM www.grc.org/volume-elect... As I am new to bsky, please share widely (do we still say retweet?). 🙏

𝐄𝐥𝐞𝐜𝐭𝐫𝐨𝐧 𝐌𝐢𝐜𝐫𝐨𝐬𝐜𝐨𝐩𝐲 𝐒𝐩𝐞𝐜𝐢𝐚𝐥𝐢𝐬𝐭 post: deadline extended! Please, share it with whoever is seeking professional growth. "Junior" profiles strongly encouraged, you'll be put on the right training track by our Specialists. careers.humantechnopole.it/o/electron-m...

Our TEaM is growing! We are looking for an EM Specialist with expertise in Volume EM applications 🦠🔬🧫 to join the CryoEM Unit at Human Technopole. Always open to questions! INFO: careers.humantechnopole.it/o/electron-m...

We are growing! The Image Analysis Infrastructure Unit @humantechnopole is looking for a Bioimage Analyst to support SPA and Cryo-ET\STA workflows. No walls between Units, great spirit on Campus. @damiandn.bsky.social and I happy to share any info! Info: careers.humantechnopole.it/o/bioimage-a...

hype. 🤩

Sjors Scheres@sjorsscheres.bsky.social · 3y ago

This should be in weeks, not months. And yes, ModelAngelo, DynaMight, Blush and new tomography pipelines will all be part of it. Thereby, this represents a major update, which will still need a bit of TLC. But we're getting there! 😀