📣 ✨Permanent Researcher Position opportunity on genome stability and/or stem cell biology at our Department✨ 📍CEA, Paris region, France 🇫🇷 shorturl.at/Cubjc Do no hesitate to contact team leaders to discuss the possibilities Please spread the word and share with potential candidates!

📣 Abstracts due July 31 for the first “Rad51 filament—molecular mechanisms & genomic stability” meeting 🌐 shorturl.at/w4Dc2 🧬 New Rad51 insights across organisms: DNA repair, replication stress, meiosis, with great speakers 🗓️ Sept 30–Oct 2, 2026 📍 ASNR, Fontenay-aux-Roses (near Paris)

RAD51 Filament – Molecular mechanisms and impact on genomic stability

Registration and payment platform

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📣 New meeting on RAD51 biology! 🌐 lnkd.in/eyV8dY_S 🔬 🧬 Come explore the latest discoveries on RAD51 biology, and its central roles in DNA repair, replication, and meiosis. ✨ Fantastic invited speakers and ample opportunities for oral presentations.

Thank you Massimo for this amazing opportunity! Really honored to be presenting at the next GiiN !!

Lopes_Lab@lopeslab.bsky.social · 4mo ago

Another great opportunity for genome integrity / replication stress aficionados to attend two excellent seminars with a simple click. Join us in a few days (Tue April 7th)! 👇

Back home after a truly inspiring trip where I had the honor to present at the Asian meeting on radiobiology at Hiroshima and at the VII Farm-DNA in São Paulo! Had the chance to connect with amazing scientists, old and new friends! Thanks so much to the organizers for these wonderful opportunities!

Super proud of Léa Girard who graduated from her Master with a really high grade and of Tiya Jahjah who defended her qualifying exams brilliantly !! You rock!!

Join us NEXT WEEK for the #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," featuring a workshop lead by Drs. Laurie Sanders and Tobias Dansen, a keynote talk by Dr. Karlene Cimprich, and more! Register Today: emgs-us.org/event/OxiDNA...

Two year postdoc position available in the Sparte lab at IGDR to investigate the crosstalk between ADP-ribosylation and SUMOylation signaling at stressed replication forks

Don't miss the next #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," presented by the EMGS DNA Repair SIG. 🧬 Register Today: emgs-us.org/event/OxiDNA...

Choose Science. Choose Europe. A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open. With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond. Apply by 10 September → europa.eu/!fBTMgF

Back home truly inspired by this fantastic meeting! Thanks so much to the organizers for putting it together!!

Vincenzo Costanzo@labvincenzo.bsky.social · last yr.

Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together!

Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together!

Really honored to have contributed with a review to this super special issue!! Thanks @albertociccia.bsky.social and @vindignilab.bsky.social for the initiative of putting together this issue on hot topics in the replication stress field!

Alberto Ciccia@albertociccia.bsky.social · last yr.

Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social. www.sciencedirect.com/special-issu...

Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways

📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP

Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.   Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...

Nature research paper: Mechanism for local attenuation of DNA replication at double-strand breaks https://go.nature.com/4k8AdCX

Mechanism for local attenuation of DNA replication at double-strand breaks - Nature

DNA double-strand breaks induce local genome maintenance and inhibition of replication initiation at nearby topologically associating domains without affecting global DNA synthesis.

go.nature.com

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability

Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.

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🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)

The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

tinyurl.com

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...

Dear all, Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk

Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td

Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability

Nature Cancer - Whalen et al. report that increased DNA end resection in BRCA-deficient, PARP inhibitor-resistant cancers leads to increased sensitivity to DNA nicks, limiting tumor formation in...

rdcu.be

It's craaazy that chemo has been in the clinic for so long, yet its therapeutic index remains incompletely understood. In this #Perspective, Letai & de The explore existing models + knowledge gaps, & suggest principles for optimizing dosing + scheduling. @natrevcancer.bsky.social bit.ly/3C53w8g

Conventional chemotherapy: millions of cures, unresolved therapeutic index - Nature Reviews Cancer

Conventional chemotherapy has successfully cured millions of patients with cancer, yet the mechanisms of action for this remain unclear. In this Perspective, Letai and de The assess the existing mecha...

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Please RT. Join the sixth edition of our Training Unit @institut_curie international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...

Celebrating 2024 and feeling super excited with the upcoming new year with this amazing group of terrific scientists I am so lucky to work with!! 🤩🤩 Happy holidays everyone and that 2025 be an awesome year for all of us !

Please join this starter pack for everyone working from chromatin replication to epigenetic inheritance and cell fate! Now still small, but we hope to gather everyone interested in joining. Please message us to be added, go.bsky.app/ALFFRUN

ok, Genome Stability people. Here are our two starter packs - since I can't pin them both independently to my profile, have to make a new post. Still adding new people to the second pack. As usual, please reach out if you would like to be added! bsky.app/starter-pack... bsky.app/starter-pack...