📢 We are looking for a PhD student to join our lab! Explore how DNA replication is regulated during development and disease using quantitative cell biology, advanced microscopy, CRISPR engineering, and AI tools. 👉 Full details: www.ibp.cz/en/for-publi... Thank you for sharing! 🔬

Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

PAF15–PCNA exhaustion governs the strand-specific control of DNA replication

Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

rdcu.be

🚀 Qlife Winter School 2026: Quantitative Approaches to DNA Damage and Repair! Hands-on workshops for Master's, PhD, postdocs & junior scientists. 🗓 Apply by Jan 19, 2026! #QlifeWinterSchool #QuantitativeBiology #LifeScienceTraining

Thrilled to share our latest work - now available in full in Nature Communications - led in my lab by @vcherdy.bsky.social, with key collaborative contributions from @nitikataneja.bsky.social . rdcu.be/eVrxX

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

Nature Communications - Replication fork plasticity upon genotoxic stress is modulated by nuclear architectural components by elusive mechanisms. Here the authors implicate Lamin A/C – best...

rdcu.be

Hana Polášek-Sedláčková @hanasedlackova.bsky.social from our Institute of Biophysics is one of 28 group leaders who just became @embo.org Young Investigators for the next four years. #LifeSciences www.avcr.cz/en/media/pre... Details ➡️ www.embo.org/press-releas...

Thrilled to be selected as one of the 28 EMBO Young Investigators for 2026! It is an incredible honor, and I am especially proud to be the second scientist from Czechia chosen since the programme began in 2001. Happy to join Tomas Pluskal in representing our country in the EMBO YIP.

EMBO@embo.org · 10mo ago

Congratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome! Read the press release here: https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/

Truly delighted to host @agagambus.bsky.social next week in Brno for an IBP Guest Lecture! Her groundbreaking work and genuinely human approach to science have always been a great inspiration to me. Come and join us for her lecture at IBP 👇

📢 Excited to share that our study has just been published in Nature Communications! We uncover how CRL4-DCAF12 regulates the cellular levels of MCMBP, a chaperone essential for assembling nascent MCM2-7 complexes, to ensure accurate and error-free genome duplication.

A comprehensive genetic catalog of human double-strand break repair | Science www.science.org/doi/10.1126/...

A comprehensive genetic catalog of human double-strand break repair

The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

science.org

@natsmb.nature.com has published three pieces on scientists returning to their country of origin after working abroad. www.nature.com/nsmb/article... Two more will come out. The most recent one by @hanasedlackova.bsky.social hits home for me, a very interesting read. www.nature.com/articles/s41...

Returning home: there and back again in Czechia - Nature Structural & Molecular Biology

Returning to Central Europe was appealing and challenging. Here, I reflect on my part in rebuilding a research career in Czechia and fostering a collaborative scientific community across the region.

nature.com

ICYMI: New online: Returning home: there and back again in Czechia

Returning home: there and back again in Czechia

Nature Structural & Molecular Biology, Published online: 07 August 2025; doi:10.1038/s41594-025-01642-1Returning to Central Europe was appealing and challenging. Here, I reflect on my part in rebuilding a research career in Czechia and fostering a collaborative scientific community across the region.

go.nature.com

📢 Excited to share my World View article, just published in @NatureSMB, where I reflect on returning to Czechia and building research group grounded in collaboration🤝, resilience and curiosity💡. www.nature.com/articles/s41...

🧑‍🔬🎙️ When you publish with JCB, you can reach more of your community by submitting a short video! Want to promote your research in your own voice? 🎦 See our guidelines: rupress.org/jcb/pages/vi... ▶️ Watch video summaries from our authors: www.youtube.com/@JCellBiol

Another reason to consider HaloTag as an alternative to GFP for tagging

Journal of Cell Biology@jcb.org · last yr.

A Biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells. New tools developed by Anoop Kumar Yadav, Abhijeet Jadhav, Hana Polasek-Sedlackova @hanasedlackova.bsky.social and colleagues: rupress.org/jcb/article/... #Technology #Chromatin #epigenetics #CellCycle

We're very proud that our recent PhD graduate (and now postdoc) Rosie Wilkins' study on RNase H2 overexpression in human cells has been published in Oncogene. www.nature.com/articles/s41...

Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress - Oncogene

Oncogene - Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress

nature.com

A Biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells. New tools developed by Anoop Kumar Yadav, Abhijeet Jadhav, Hana Polasek-Sedlackova @hanasedlackova.bsky.social and colleagues: rupress.org/jcb/article/... #Technology #Chromatin #epigenetics #CellCycle

Thank you, Melina, for the interview!

Nature Structural & Molecular Biology@natsmb.nature.com · last yr.

New online: Q&A with Francesca Mattiroli

📢 For all HaloTag lovers💙💚💛❤️💜🩶 we are excited to share that our work, in which we developed a new biotin-HaloTag ligand, is now published in @jcb.org! Full link here: rupress.org/jcb/article-...

Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...

In @jcb.org, the @hanasedlackova.bsky.social lab presents a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...

It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...

CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS

Abstract. Disassembly of the replication machinery (replisome) from chromatin is an active process driven by two ubiquitin ligases Cul2LRR1 and TRAIP, whic

academic.oup.com

Apply to our PhD program!!

Hubrecht Institute@hubrechtinstitute.bsky.social · last yr.

🧬 Looking for a PhD position in molecular or developmental biology? 🔬 ✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/

Finally out in Nature Chem Bio: SNAP-tag2 for faster and brighter protein labeling www.nature.com/articles/s41... Thank you Steffi and Veselin.

SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology

SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...

nature.com

This review discusses the cellular pathways mediating Targeted Protein Degradation approaches and points to some gaps in our understanding of the biology of novel therapeutic tools such as PROTACs. doi.org/10.1038/s420...

Cellular parameters shaping pathways of targeted protein degradation - Communications Biology

This review discusses the cellular pathways mediating Targeted Protein Degradation approaches and points to some gaps in our understanding of the biology of novel therapeutic tools such as PROTACs.

doi.org

This editorial details why we think it's a good idea to standarise reporting of microscopy data and what we are doing towards that. I also feel that it is both important and a step towards helping the community. www.nature.com/articles/s41...

Postdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

If you are interested in working on chromatin and oogenesis in the mouse in beautiful Copenhagen, we are recruiting a postdoc! jobportal.ku.dk/videnskabeli... Please share!

📣Check out our recent review (written with Martina Huranova lab) on converging mechanisms controlling #cilia #dynamics during #cell #cycle, #cell #signaling, and cross-talk of ciliary modules. rdcu.be/epVDc

So excited to share that we @natsmb.nature.com are hiring a new editor! If you are interested about working with an intelligent, compassionate and funny team helping scientists publish great research, please consider applying. Deadline June 20th. springernature.wd3.myworkdayjobs.com/SpringerNatu...

Associate or Senior Editor (Nature Structural & Molecular Biology and Nature Communications)

Job Title: Associate or Senior Editor (Nature Structural & Molecular Biology and Nature Communications) Location: New York, Shanghai, Beijing, Madrid or Milan Closing date: June 20th About Springe...

springernature.wd3.myworkdayjobs.com

Next Tuesday's webinar will feature @agagambus.bsky.social and @chowdhurylab.bsky.social. Join us on June 3rd at 5PM Rome / 11AM NYC for a lively discussion on DNA replication and repair! Zoom link: uniroma1.zoom.us/j/95149984403 Become part of our community: docs.google.com/forms/d/e/1F...