Published in The New England Journal of Medicine. Peer-reviewed. Large sample size. Sound methodology. An antiviral pill has, for the FIRST time, been shown to PREVENT COVID-19 in individuals exposed to SARS-CoV-2. Ensitrelvir blocks the enzyme coronaviruses need to make new copies of themselves.

Absolutely thrilled 💣 to share our preprint 🖨️: "Mapping active cis-regulatory elements from transcription initiation events”. www.biorxiv.org/content/10.6... We introduce nucCAGE and PRIME to identify active cis-regulatory elements (CREs) and disease-associated, non-coding variants.

Visualising heteroplasmic mitochondrial DNA variants in situ? Now out as #mtDNA-smFISH in @cp-devcell.bsky.social! We find purifying selection against pathogenic mtDNA variants through genetic bottlenecks in the germline and the developing brain. www.cell.com/developmenta...

Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in vivo

Chandrasegaram et al. directly visualize mitochondrial DNA inside intact cells and tissues and reveal how genetic cell-to-cell variability arises during development. They show that somatic bottlenecks...

cell.com

Germ cells have their own versions of core transcription factors and fertility depends on them. We're hiring a PhD student to figure out how! 📢 Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 Deadline May 1 👇 Please share with anyone who might be interested!

Dear gene regulation aficionados in the wider Copenhagen 🇩🇰area: Please feel cordially invited to our 3rd Copenhagen Gene Regulation Seminar 👨‍🏫 next week on Thursday, the 5th of March. 📆 Hope to see you in Panum for 2 exciting talks! 👇

DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!

Post-replicative chromatin accessibility predicts cell fate change

Knudsen and colleagues use repli-ATAC-seq to compare replicated and unreplicated chromatin in two models of cell identity change. They find that lineage-specific elements are accessible earlier in rep...

cell.com

Join us for a day of talks, posters, and discussions, featuring a morning joint lecture with Nobel Laureates Eric F. Wieschaus and Christiane Nüsslein-Volhard! Date: Monday, May 4th, 2026 Location: University of Copenhagen, Mærsk Tower sites.google.com/view/emergin... Free to participate

Healthcare in Greenland is publicly funded, free at the point of use, and despite geographical challenges considered very good. Healthcare costs in the USA are extortionate and responsible for 60% of all US bankruptcies. So maybe Denmark should be sending hospital ships the other way.

Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.

Nature Biotechnology@natbiotech.nature.com · 6mo ago

Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR - @yaruidiao.bsky.social @dukehealth.bsky.social go.nature.com/4rZqimf

How resilient are tissues to cell mispositioning and loss, and how do they restore their cell numbers? Check our latest work, from @ybellaichelab.bsky.social Congratulations to all authors. Artwork from the artist @lale-alpar.bsky.social (lalealpar.com) www.cell.com/developmenta...

Tissue mechanics and systemic signaling safeguard epithelial tissue against spindle misorientation

Bosveld et al. identified a multilayered system of safeguards that reuses homeostatic mechanisms to maintain epithelial integrity and cell number in the face of spindle misorientation. This work delin...

cell.com

In 1927, Vera Menchik became the first Women's World Chess Champion at age 21 & is the longest-reigning women's champion in #chess history. She defended the title 7 times, held it undisputed until her tragic death in 1944 at age 38 in a V-1 rocket bombing during #WWII. She was born #OTD in 1906.

Interested in transcriptional regulation, enhancers and 3D genome folding? In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control www.biorxiv.org/content/10.6... detailed 🧵👇

And a new paper from the lab. A follow up to a previous study in which we elucidate the mechanism of the nuclear transport. Read the full story: www.nature.com/articles/s41...

IMP@impvienna.bsky.social · 6mo ago

To regulate gene activity, proteasomes - waste disposal machines of cells - must enter the nucleus. IMP Researchers now show how the adaptor protein AKIRIN2 helps ferry this massive complex through the nuclear pore: https://www.nature.com/articles/s41467-026-69162-0

1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...

I think that, like with art, papers offer an opportunity for you to tell the story your own way. Could another person research the same question? Yes. However, each person has the opportunity to do it and communicate it in their own way, and we must protect that 🧪

We need to teach PhD students how to write a great cover letter - one that links their research to a future lab’s goals, shows genuine enthusiasm, and clearly explains fit. It’s not a CV summary or a formality; it’s their first real conversation with future colleagues.

🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...

Every American needs to watch this:

Auschwitz was at the end of a process. We must remember that it did not start from gas chambers. This hatred gradually developed: from ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder. Auschwitz took time.

Congratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳

Our work on improving human egg quality was featured in @theguardian.com. We hope this will help to make #IVF more successful and allow more couples to conceive. 💜

Human eggs ‘rejuvenated’ in an advance that could boost IVF success rates

Exclusive: Research suggests supplementing eggs with a key protein reduces age-related defects, raising hopes of improved IVF for older women

theguardian.com

I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories! link.springer.com/collections/...

Jeg står her omkring i morgen fra ca. kl 10 og frem til 11:30 eller der omkring. Så går turen videre til Panum. Håber vi ses!

Bizarre that our 2020 #Drosophila #AMP review already feels out of date. Thanks to #AnnualReviews to cover the many updates in the field and present a much more complete picture of the diversity, mechanisms, topics, of fly immunity re: host defence peptides. www.annualreviews.org/content/jour...

We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale See preprint for: — Ensembles of >12000 full-length human proteins — Analysis of IDRs in >1500 TFs 📜 doi.org/10.1101/2025... 💾 github.com/KULL-Centre/...

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 10mo ago

AF-CALVADOS: AlphaFold-guided simulations of multi-domain proteins at the proteome level https://www.biorxiv.org/content/10.1101/2025.10.19.683306v1

Our collab w. V Goel, @nicholas-aboreden.bsky.social , J Jusuf, G Blobel, L Mirny, @irate-physicist.bsky.social out in @natsmb.nature.com www.nature.com/articles/s41... Was co-submitted with @allanaschooley.bsky.social @jobdekker.bsky.social whose paper should also come out soon Brief thread 👇

Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology

Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...

nature.com

Ed Banigan@irate-physicist.bsky.social · 2y ago

been lurking here a while but time to spend less time in the bad place Here's my latest work in collab w/ Viraat Goel, @andersshansen.bsky.social, Leonid Mirny, Nick Aboreden, Gerd Blobel et al. Dynamics of microcompartment formation at the mitosis-to-G1 transition www.biorxiv.org/content/10.1...

“Harvard geneticist David Reich said … increasingly sophisticated analysis of genetic material made possible by technological advances shows that virtually everyone came from somewhere else, and everyone’s genetic background shows a mix from different waves of migration that washed over the globe.”

Pure bloodlines? Ancestral homelands? DNA science says no. — Harvard Gazette

Geneticist explains recent analyses made possible by tech advances show human history to be one of mixing, movement, displacement.

news.harvard.edu

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

HDAC3 prevents enhancer hyperactivation to enable developmental transitions

Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...

biorxiv.org

Guess, I'll have a coffee then.

Excited to share our Review on human PGC development covering the latest in vivo observations & in vitro developments, esp. in the last 5 years. Have a read! journals.biologists.com/dev/article/... From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social

Emerging principles and models of human primordial germ cell development

Summary: This Review examines recent insights into early human germ cell development and how these regulatory principles guide stem cell-derived models aiming to reconstitute human gametogenesis in vi...

journals.biologists.com