Romberg Lab
@romberglab.bsky.social
Solving immunologic mysteries at UPenn and CHOP since 2015 www.romberglab.org
Great story, great science!
Journal of Human Immunity@jhumimmunity.org · 3mo agoX-linked SEPTIN6-related congenital neutropenia and B cell deficiency. new study from Lauren M. Gunderman, Eric J. Allenspach and colleagues @seattlechildrens.org: rupress.org/jhi/article/... #InbornErrorsOfImmunity #ClinicalPhenotypes #Septins #Bcells
CHOP'S 8th Immune Dysregulation Course will be held in person and virtually on June 10th. It will be a buffet of great speakers discussing inflammation in immune-privledged sites. Thanks to generous support from the Jeffrey Modell Foundation, registration and CME credit is completely free.
Project Hail Mary is a beautiful brilliant film. But molecular biologists be warned there's a deeply disturbing scene midway through when Ryan Gosling's scientist places two eppendorfs directly next to each other in an otherwise empty unbalanced microcentrifuge & sets it spinning with wild abandon.
Tough diagnoses being made with artificial thymic organoids at CHOP! @chopresearch.bsky.social
Journal of Human Immunity@jhumimmunity.org · 6mo agoGrier et al. @childrensphila.bsky.social report that mutations in DNA helicase RECQL4 can cause immunodeficiency, including #SCID. The T cell defects are intrinsic to the hematopoietic system and amenable to hematopoietic stem cell transplant. rupress.org/jhi/article/... @romberglab.bsky.social
Congratulations to the 6 @pennmedicine.bsky.social physician-scientists elected to the American Society for Clinical Investigation (@the-asci.org) class of 2026! Please check back as we profile each new member tinyurl.com/4ejz2cnm
Thrilled to be presenting on Inborn Errors of Immunity at #PathUpdate2026 — see you in Sydney 🦘🐨🏄🇦🇺🌏! rcpa.me/pathupdate-26
1/ We’re seeking Sponsors for the 3rd International Symposium on Inborn Errors of Immunity (IEI), and their phenocopies, to be held in Lofoten, Norway, in June 2027. www.hgid.org/collaborativ...
Re-watching The Office with my kids…realizing my PI leadership style is very Michael Scott…. Pray for me
a man in a suit and tie stands in front of a framed certificate that says ' award ' on it
ALT: a man in a suit and tie stands in front of a framed certificate that says ' award ' on it
media.tenor.com
Our recent work describing extreme enrichment of complement factor I deficiency in the Amish from @jacionline.bsky.social was featured on the front page of the Philadelphia Inquirer (@inquirer.com). Above the fold (and the Eagles!). (static1.squarespace.com/static/65273...)
Another immune masterclass in @jhumimmunity.org. This journal is on a tear!
Rockefeller University Press@rupress.org · last yr.Tobin and @macattacklab.bsky.social review #InbornErrorsOfImmunity that can present with rheumatologic and #autoimmune complications and the role of genetic testing for establishing a molecular diagnosis & devising personalized treatment plans to improve patient outcomes. rupress.org/jhi/article/...
.@alneehus.bsky.social, @romberglab.bsky.social and @bloodgenes.bsky.social review how genetic variation impacts early B cell development, & discuss inherited rare variants & more common polymorphisms that predispose to B cell-related immune disorders & malignancies rupress.org/jhi/article/...
Nice commentary by the one and only Stu Tangye in Blood hyping our recent paper on PU.1 agammaglobulinemia.
romberglab.org
PU.1 haploinsufficiency causes agammaglobulinemia and dendritic-cell deficiencies with incomplete penetrance and variable expressivity. buff.ly/itn0zjd #hemesky #immunobiologandimmunotherapy
🚨New Paper Alert🚨 Now out in @bloodjournal.bsky.social We scoured the ends of the earth for rare human PU.1 variants and subjected 134 of them to suite of functional assessments.
Interested in translational human immunology? We are currently recruiting a PhD student or a post-doc to work on an exciting project to to study immune changes leading to the development of type 1 diabetes. #immunosky #sciencejobs uef.varbi.com/en/what:job/...
Postdoctoral Researcher/Doctoral Researcher/Project Researcher, Translational Immunology
The University of Eastern Finland is inviting applications for a Postdoctoral Researcher/Doctoral Researcher/Project Researcher (Translational Immunology) position in Kuopio. The position will be fill
uef.varbi.com
In @jhumimmunity.org, Hajjar et al. identify distinct gut #microbiome profiles in common variable #immunodeficiency patients with noninfectious complications and establish a novel germ-free mouse model using fecal microbiota transplant. rupress.org/jhi/article/...
At last!
Journal of Human Immunity@jhumimmunity.org · last yr.The first JHI articles are online! Poli et al present the 2024 update of the @iuis-online.bsky.social classification of #InbornErrorsOfImmunity (rupress.org/jhi/article/...) & Bousfiha et al provide an accompanying phenotypic classification to assist clinical diagnoses (rupress.org/jhi/article/...)
JHI Associate Editor Neil Romberg @romberglab.bsky.social is an Associate Professor at the University of Pennsylvania, with a special interest in humoral immunity. Learn more about JHI 📗 https://buff.ly/42FXtBZ
Immune response to co-administration of bovine tuberculosis and contraceptive vaccines in badgers (Meles meles) https://www.biorxiv.org/content/10.1101/2025.02.12.637632v1
Grateful to see @retractionwatch.com share our story! Learn more about the launch of Journal of Human Immunity, why our editors made the move, and what’s next for our nonprofit journal with @rupress.org. Insights from our EiC @casanovalab.bsky.social here: retractionwatch.com/2025/02/06/e...
Editors resign from Springer immunology journal to launch nonprofit title
Several top editors of the Journal of Clinical Immunology, a Springer Nature title, have jumped ship to start a new, nonprofit journal with Rockefeller University Press. Jean-Laurent Casanova…
retractionwatch.com
Welcome to the future of #HumanImmunity research! @rupress.org and the International Alliance for Primary Immunodeficiency Societies (#IAPIDS) are launching the Journal of Human Immunity (JHI)! Stay tuned for groundbreaking, #OpenAccess research! 👉 https://buff.ly/4ajqm8W
Reposting the IEI starter pack as there are new additions!
Here’s to all the abnormal normals out there…range life
Don Vinh@donvinh.bsky.social · 2y agoImagine your 🩸test results compared not to a ‘standard reference range’, but to your own values as well. Some reference ranges are based on an archaic, primarily Caucasian reference. Misserves some demographics. Ferritin is an example, 📈in Asians. #PersonalizedMed www.nature.com/articles/d41...
Romberg Lab Merch alert! This year’s frosted mug rates just above the Romberg Lab Softball T-shirt and just below the Romberg Lab Fanny Pack (aka the GOAT). www.romberglab.org/merch-store
