How can an extremely simple equation open the door to virtually infinite complexity? Fifty years ago, Bob May’s classic paper in @nature.com on chaos showed how deterministic rules can generate unpredictability, with deep implications for ecology, physics & beyond. mym.iimas.unam.mx/ramon/docs/M...

🎉 Excited to receive an #ERCPoC grant! QrCiliopathies will test the hypothesis that glutamine sensing is critical in renal ciliopathies, and an actionable node for therapeutics development. In PKD and beyond. #cilia #metabolism #mitochondria #PKD

The latest article by @veronicabiga.bsky.social uses live-imaging and mathematical modelling to understand how hybrid states emerge in a cross-repressive transcription factor motif!

@veronicabiga.bsky.social · 2mo ago

Our latest study is now available online!

Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors

Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors

Comparing signaling response profiles and fate outcomes in single cells reveals logic and limits of signal interpretation.

buff.ly

We are looking for an experienced light microscopy specialist, motivated to support our users in the Advanced Light Microscopy Facility at EMBL Heidelberg. embl.wd103.myworkdayjobs.com/en-US/EMBL/j... -closing date 11 May 2026 @eurobioimaging.bsky.social @globalbioimaging.bsky.social

embl.wd103.myworkdayjobs.com

These two books contain the sum total of all human knowledge

A wrap-up of @events.embl.org #EESBioOsc Biological Oscillators meeting! sites.google.com/view/dynamic...

Dynamical Systems (in) Biology - Updates

01/04/2026: A wrap-up of EMBL's Biological Oscillators meeting It was great to visit the EMBL in Heidelberg for be Biological Oscillators 2026 meeting, by far one of my favourite ones. An occasion to ...

sites.google.com

Unfortunately @events.embl.org #EESBioOsc is coming to an end. As usual it was a scientific treat, and seeing @sarapozzi.bsky.social present her work was a highlight of the meeting. Nicely done!

So grateful to my buddy the great @davidemazza.bsky.social and all the contributors from our teams to this joint effort to unravel NF-κB–p53 crosstalk. Davide’s thread nicely explains the main findings — here’s a short side note from me 🧵👇 (1/n)

Davide Mazza@davidemazza.bsky.social · 5mo ago

🧵 I’m very happy to share a new preprint from the @samuzambrano.bsky.social group and ours — a project driven by @emabiong.bsky.social, a PhD student bold enough to tackle a question at the interface of our two expertises: how the biological oscillators p53 and NF-κB talk to each other.

What we found surprised us: these two transcription factors cooperate at the molecular level, yet this cooperation produces functional antagonism. Even more intriguingly, inflammatory signals can impair DNA repair by reshaping the temporal dynamics of p53. If you’re curious, here’s the story 👇

🧵 I’m very happy to share a new preprint from the @samuzambrano.bsky.social group and ours — a project driven by @emabiong.bsky.social, a PhD student bold enough to tackle a question at the interface of our two expertises: how the biological oscillators p53 and NF-κB talk to each other.

New preclinical work in #ScienceSignaling reveals how #Tcells respond in real time to signaling inputs of varying intensities and could shed further light on how these cells become activated in the context of immunity and inflammation. https://scim.ag/4qN2h1d

Antigen affinity modulates ERK pulsing frequency during T cell activation

Real-time, single-cell imaging reveals ERK signaling dynamics in response to T cell receptor stimulation.

scim.ag

#FluorescenceFriday Proud of our the last paper @cellcommlab.bsky.social & 1st one of @jboixcampos.bsky.social We continue to study #CellMigration & how cells decide where to go: ↖️↗️⬇️? (movie of the actin #cytoskeleton) Full www.science.org/doi/10.1126/... @focalplane.bsky.social @science.org 🧪🔬

Blog post: Chance favors the (theoretically) prepared mind Data is big, machines are learning, so what good is theory anyway? Isn't most discovery driven by serendipity anyway, with theory mostly a "post-mortem"? I argue that this view discounts the value of theory. open.substack.com/pub/arjunraj...

Chance favors the (theoretically) prepared mind

In defense of the role of theory in innovation

open.substack.com

Extremely funny to call the pope “holier-than-thou”

Fig. 6: Mathematical model

Network Medicine is entering a new phase: one that demands we rethink how we study, model and ultimately treat complex diseases. www.sciencedirect.com/science/arti... #ComplexSystems #NetworkScience #Medicine #MedSky 🧪🧬🌐 🧵 1/

Halloween is a nice day to share our new site, where you can find more info on what our team does. It can briefly be summarized as Dynamical Systems (in) Biology: sites.google.com/view/dynamic...

Dynamical Systems (in) Biology

We are a team interested in (nonlinear) dynamical systems, in cell biology, in systems biology and in combinations of these elements. Here you can learn about us, who we are, what we publish, how to c...

sites.google.com

How do dynamics of signalling molecules skew cell fate decisions? With this review we try to move our first steps in the signalling dynamics field, together with the expert lead of @samuzambrano.bsky.social! Kudos to Fulvio, Sara and Erika for their excellent work!

Samuel Zambrano@samuzambrano.bsky.social · 10mo ago

Cells respond to stimuli by activating signaling pathways with a surprising variety of dynamics. Why? As we review here, there is growing evidence connecting dynamics with specific cell fate decisions www.frontiersin.org/journals/cel...

Cells respond to stimuli by activating signaling pathways with a surprising variety of dynamics. Why? As we review here, there is growing evidence connecting dynamics with specific cell fate decisions www.frontiersin.org/journals/cel...

Frontiers | Linking signaling dynamics and cell fate decisions through single-cell imaging: evidence and challenges

Our ever-growing capacity to observe dynamic processes at the single-cell level has highlighted how cells use complex signaling dynamics to provide adequate ...

frontiersin.org

New @nejm.org One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing www.nejm.org/doi/full/10.1056/NEJMoa2400521

DB-OTO Gene Therapy for Inherited Deafness | NEJM

Genetic deficiency of otoferlin, a protein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafness. Medicines to treat the condition are lacking; children...

nejm.org

How dit life originate in our planet? How can we create it in the lab?Our @royalsocietypublishing.org Theme Issue "Origins of Life: the possible and the actual", coedited with @sfiscience.bsky.social C Kempes and Susan Stepney is out! royalsocietypublishing.org/toc/rstb/202... @manlius.bsky.social

Philosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1936

royalsocietypublishing.org

How do you prevent cacio e pepe sauce from congealing? A thoroughly researched answer earned its authors a prize!

Pasta Physics Scoops Up an Ig Nobel Prize

A group of Italian physicists was awarded the Ig Nobel Prize in Physics for their study of the phase diagram of a cheesy sauce renowned in Italy.

physics.aps.org

I wrote a response to Thomas Friedman's "magical thinking" on AI here: aiguide.substack.com/p/magical-th...

Magical Thinking on AI

A Response to Thomas Friedman's Recent AI Columns in the New York Times

aiguide.substack.com

Melanie Mitchell@melaniemitchell.bsky.social · 11mo ago

Just reading the Friedman AI articles in the NYT. There is *a lot* of magical thinking in them. E.g.: "We discovered in the early 2020s that if you built a neural network big enough, combined it with strong enough A.I. software and enough electricity, A.I. would just emerge." (1/2)

David Baltimore passed away this weekend. A pioneer of molecular virology who won the Nobel prize in medicine & physiology for his discovery of viral reverse transcriptase. This essay he wrote in 2018 reflecting of his 60yr career in science is a great read. www.annualreviews.org/content/jour...

Our @ourworldindata.org we visualise weekly updates of wildfire data from the Global Wildfire Information System. Spain was having a pretty low/average year until the past few weeks when it went roaring past previous years. You can track this data here: ourworldindata.org/wildfires

My new @science.org editorial on the role of scientists in defending democracy is out today. As authoritarianism takes hold in the US, we must fight for the democratic principles that enable a free society and scientists have a key role. I hope you'll join us. www.science.org/doi/10.1126/...

Scientists’ role in defending democracy

The United States’ democratic leadership, commitment to freedom of expression, and investment in the pursuit of knowledge have long enabled its preeminence in science and technology. Yet today we are ...

science.org

🎯

TanentzapfLab@tanentzapflab.bsky.social · 12mo ago

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.

There is something harder than reviewing a manuscript: reviewing a very bad manuscript.