Preprint from marignanilab.com. LKB1 isn't just a tumour suppressor kinase with metabolic function; there's more😁. We used scRNAseq, CRISPR, patient tumours, METABRIC genomics & new mouse model to ask:what is the impact of losing LKB1 expression on breast cancer? www.biorxiv.org/content/10.6...

Vibrational optoacoustic detection of lipid-membrane dynamics enables label-free imaging of cell membrane potential #SingleCell 🧪🧬🖥️ https://www.biorxiv.org/content/10.64898/2026.06.18.733116v1

🚨#Preprint alert! @antoranlab.bsky.social in close collaboration with @imartincorena.bsky.social lab www.biorxiv.org/content/10.6... How can we study human #epithelial tissues for months in the lab, while preserving their native structures and behaviour but without passaging?

Human 3D epithelioids enable continuous long-term clonal evolution studies across multiple epithelial tissues

Modeling human epithelia in vitro remains challenging because current systems do not fully preserve the combination of architecture, heterogeneity, clonal composition, and long-term dynamics shown in ...

biorxiv.org

Are you interested in learning multiomics analysis for your project? Join me for a hands-on workshop at Bilimler Köyü (Village of Sciences) in Foça, İzmir for a week. #spatialtranscriptomics #scrnaseq

Upskill in #scRNAseq! Our July workshop covers QC, normalisation, and clustering in R. Learn the ‘why’ behind the workflow with expert facilitators. Applications close 13 July: www.biocommons.org.au/events/scrna... #NCRISImpact #SingleCell

WORKSHOP: Single cell RNAseq analysis in R — Australian BioCommons

Analysis and interpretation of single cell RNAseq (scRNAseq) data requires dedicated workflows. In this hands-on workshop we will show you how to perform single cell RNAseq analysis using a number of tool. More information Apply

biocommons.org.au

💨☕👩‍💻Excited to share our recent discovery. Tumour suppressors LKB1 and SMARCA4 working together to regulate gene expression, acting as a nexus between metabolism and chromatin remodelling. #LungCancer #CancerResearch #Epigenetics #Metabolism #LKB1 #SMARCA4 www.frontiersin.org/journals/cel...

Frontiers | Tumor suppressors LKB1 and SMARCA4 functionally interact to regulate gene expression across diverse biological processes in lung cancer

IntroductionThe tumor suppressor kinase liver kinase B1 (LKB1) is known to regulate the activity of the metabolic sensor AMP-activated protein kinase (AMPK),...

frontiersin.org

Excited to share our work published in @cp-immunity.bsky.social! We investigated the role of HIF-1α in CD4 T cells using #Xenium spatial transcriptomics in infected lungs containing #TertiaryLymphoidStructures (TLS) (1/10). www.cell.com/immunity/ful...

HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung

Tertiary lymphoid structures are critical components of tissue immunity, necessitating better understanding of their organization and immune functions. De Lima et al. investigate the spatial and tempo...

cell.com

🆕 New Study: Scientists working on a Gut Cell Atlas have conducted #singlecell #RNAseq on intestinal cells, discovering clusters of immune and endothelial cells localise around scar tissue in the submucosa. 🧬💻 ➡️ buff.ly/0Y9bpZN @uoe-igc.bsky.social @helmsleytrust.bsky.social #CellAtlas #scRNAseq

New study maps cellular mechanisms driving fibrosis in Crohn's Disease

Researchers at the Earlham Institute, the University of Edinburgh and Heriot-Watt University have analysed gut cells to understand the drivers behind fibrosis (scarring), a common complication in Crohn’s Disease affecting 10-20% of patients.

buff.ly

🚀 Course: Advanced Python for Data Science & Bioinformatics 📅 23–26 March | 🌍 Online Ready to level up your Python skills for biology? Dive into data wrangling, BioPython, visualization & machine learning, and build an end-to-end project 🐍📊🧬 www.physalia-courses.org/courses-work... #Python

A minimal PyTorch re-implementation of AlphaFold2 github.com/ChrisHayduk/... We need more stuff like this. The incentive is to always be making the new groundbreaking tool, while maintenance + improvement of "old" tools gets left behind. But there is still heaps to be gained in "old" tools

The process of #PeerReview is vital to contemporary science, but is also under enormous strain. @carlbergstrom.com & Kevin Gross use mathematical models to dissect the threats to the long-term viability of peer review, suggesting ways to stabilize it @plosbiology.org 🧪 plos.io/4kR02bo

As scRNA-seq cohorts grow in scale (e.g. FinnGen, TenK10K), so does the need for methods that can handle millions of cells from thousands of donors. LIVI's scalable design enables systematic trans-eQTL discovery in such datasets, revealing cellular mechanisms underlying complex disease risk. 11/n

Working on trans-eQTL mapping with population-scale scRNA-seq? Meet LIVI, our latest framework that enables efficient trans-eQTL mapping at single-cell resolution across cohorts of hundreds to thousands of donors. Preprint: doi.org/10.64898/202... Summary in the 🧵 below by @danaivagiaki.bsky.social

Danai Vagiaki@danaivagiaki.bsky.social · 6mo ago

Delighted to present Latent Interaction Variational Inference (LIVI), a framework for trans-eQTL mapping at single-cell resolution that I developed during my PhD together with colleagues from @steglelab.bsky.social 1/n

Allele-specific splicing modulates protein isoforms and Alzheimer's risk https://www.biorxiv.org/content/10.64898/2026.02.13.705796v1

📝 Researchers identify potential immune evasion mechanism in premalignant lung lesions ✍️ RNA-Seq Blog

📝 Nanopore sequencing of intact aminoacylated tRNAs ✍️ RNA-Seq Blog

When asked to draw a scientist, school-age kids in the United States are increasingly sketching women, according to a study from 2018. Read more on #WomenInScienceDay: https://scim.ag/4qFrPON

A LaTeX package to add coffee strains to your documents😆 framagit.org/Pathe/coffee...

Patrick / coffeestains · GitLab

This package provides an essential feature to LaTeX that has been missing for too long. It adds a coffee stain to your documents. A lot of time can...

framagit.org

Biological data governance in an age of AI www.science.org/doi/10.1126/... #biosecurity

the Epstein files are really devastating because they remind me of how many girls and women miss out on professional opportunities, mentorship and careers because of how many powerful, rich and influential men only view girls and women — and interactions with them — through the lens of sex

"Both research papers and salami can be cut into multiple, smaller pieces." Insightful. en.wikipedia.org/wiki/Least_p...

Least publishable unit - Wikipedia

en.wikipedia.org

Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...

Transcriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of Psychiatry

Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...

doi.org

A Most Powerful Test for Gene-Gene Interaction in the Presence of Main Effects https://www.biorxiv.org/content/10.64898/2026.01.30.702572v1

I made a filterlist for uBlock Origin to remove Generative AI features on websites. Includes blocks for * Google AI Summaries * YouTube Ask button & chat summaries * GitHub Copilot * Facebook AI chat * X's Grok buttons * Deviantart DreamUp * Booru AI images * And more github.com/Stevoisiak/S...

A reminder that proteins are highly dynamic molecules. 🟧 We have made much progress in measuring & predicting static protein structures, but the dynamics that animate life remain challenging to measure & model.

Guide to multi-omics integration with toy examples: supervised latent components (DIABLO), unsupervised shared/partial/unique structure (DIVAS), VAEs/conditional VAEs, and key baselines (MOFA, JIVE, SNF) with practical tips + code. github.com/Trhova/Multi...

Advancing regulatory variant effect prediction with AlphaGenome www.nature.com/articles/s41... 🧬💻🧪 Code: github.com/google-deepm... Author roundtable: www.youtube.com/watch?v=V8lh...

This preprint combines cell-line scRNA-seq reanalysis with bulk LUAD checks in cBioPortal. The cross-dataset consistency for metabolic and cell cycle terms is encouraging.

bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · 7mo ago

Tumour suppressors LKB1 and SMARCA4 functionally interact to regulate gene expression of diverse biological processes in lung cancer https://www.biorxiv.org/content/10.64898/2026.01.26.699134v1