🚨 Excited to share that our new paper is published today in Neuron ! We show that P2Y2 receptor activation restores cerebrovascular function and reverses behavioural impairments in mice carrying a 16p11.2 deletion. #Autism #Publication #BasicScience www.cell.com/neuron/fullt...

Purinergic receptor activation rectifies autism-associated endothelial dysfunction

Ouellette et al. report that a 16p11.2 deletion induces a bioenergetic failure in brain endothelial cells. Activation of purinergic signaling via P2Y2 receptors restored endothelial function and impro...

cell.com

Exciting opportunities at a world-class institute in Toronto! apply.interfolio.com/192324

I'll save you the click-through: A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet. It's plausible that Claude found the same signatures independently...

Carl Zimmer@carlzimmer.com · last wk.

Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc

Check out the WCVM: Sept 25-26 “The two-day event opens up the veterinary college to the public to showcase the veterinary profession and to highlight the many roles of veterinarians in animal health, public health, research, industry and community service.” #Saskatoon wcvm.usask.ca/education/ve...

Vetavision 2026 - Western College of Veterinary Medicine

wcvm.usask.ca

Here's a way to get a pure science shot on Bluesky: a custom feed that only shows the posts from people you follow that are linked to a DOI bsky.app/profile/pape...

Paper Skygest Team@paper-feed.bsky.social · last yr.

**Please repost** If you're enjoying Paper Skygest -- our personalized feed of academic content on Bluesky -- we'd appreciate you reposting this! We’ve found that the most effective way for us to reach new users and communities is through users sharing it with their network

What in the world am I looking at here? @Nikon? www.nikonsmallworld.com/galleries/20...

Abnormal beating of airway cilia from a child with Primary Ciliary Dyskinesia (PCD) | 2026 Small World in Motion Competition

Ning Xu - Abnormal beating of airway cilia from a child with Primary Ciliary Dyskinesia (PCD), a genetic disorder affecting respiratory function.

nikonsmallworld.com

You know what's also interactive? Reading the paper. Talk to your colleagues about the paper you just read. Tell them why you loved it. Tell them why you hated it. And even better: invite the authors to talk about their paper 🧪

Ran Blekhman@blekhman.bsky.social · 3w ago

This is the future of scientific papers. Instead of a PDF, the paper is an AI agent that you can talk to, ask questions, run analyses. No more digging through supplements - just ask the paper directly: "what p-value cutoff was used in Fig 3B? Re-run at 0.01." www.nature.com/articles/s41...

🚨Thrilled to share our latest work is out!🚨 Ever wondered how epicardial activation regulates the immune response during cardiac regeneration? Yes? Check it out. No? Check it out anyway. 😉 Huge congrats to @gurrr.bsky.social and @gulsumkayman.bsky.social ! 🔗 link.springer.com/article/10.1...

Sulf1 regulates inflammation via modulation of TGF-β dependent epicardial activation - EMBO Reports

Unlike adult humans, zebrafish can regenerate their hearts after injury. After cardiac injury, the epicardium is rapidly activated to contribute both signaling factors and progenitor cells that are es...

link.springer.com

This is the update I was most excited to release so far. This week, Cell Culture and Lab Assistant (free iOS App) gets a new update: Sequences (Beta) 🧬 It is a beta, so some things might not work as intended yet. They will be fixed. 😅 The update will be live this week.

🧵 What if one reason fertility declines with age isn’t just genetic-but mechanical? Thrilled to share our new paper in @NatureCellBio : Elevated contractility drives implantation failure in mouse embryos from aged females… here’s what we found 👇 www.nature.com/articles/s41... 1/11

Elevated contractility drives implantation failure in mouse embryos from aged females - Nature Cell Biology

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

nature.com

Really cool tools! Tracing the origins of de novo coronary collateral formation in cardiac repair www.science.org/doi/full/10....

This is bonkers.

Reese Richardson@reeserichardson.bsky.social · last mo.

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

🚨 Want to isolate astrocytes and study their function? With Nicole Blakeley, PhD Candidate in our lab, we are happy to present a new protocol, which hopefully will help labs dive into glial biology with less hurdles. Cheers ! #glia #astrocytes

Protocol for assessing molecular signatures and metabolic function of primary murine cortical astrocytes

Astrocytes are the most numerous brain cells and are central to the regulation of brain metabolism. Here, we present a protocol for identifying molecular signatures and assessing the metabolic functio...

cell.com

For the zebrafish folks, in case you don't know: if you use it -which you do-, you can cite ZFIN as Bradford et al 2022 academic.oup.com/genetics/art... 🧪🐟

Zebrafish information network, the knowledgebase for Danio rerio research

Abstract. The Zebrafish Information Network (zfin.org) is the central repository for Danio rerio genetic and genomic data. The Zebrafish Information Networ

academic.oup.com

MwahahahahahadScientist@mads100tist.bsky.social · 2mo ago

I am very serious about citing resources (ZFIN, Flybase, Wormbase, yeast, mouse, rat, human, etc) and asking authors to cite them precisely for this reason: the more we talk about them and cite them in our papers, the better chance we have at justifying why we should increase the budget 🧪

Proud to share our new paper in EMBO Reports! 🧬 How does a cell "decide" to become lymphatic vs blood endothelium? Turns out it's not just which genes switch on — it's how the genome folds around them. 💥 link.springer.com/content/pdf/... #Lymphatics #Zebrafish #DevBio #VascularBiology #Genomics

Wake up babe! A new online resource for fish nerds just dropped. 🐟🧪 www.floridamuseum.ufl.edu/discover-fis...

Fish Families of the World Gallery

This searchable gallery includes entries for fish families of the world, which may include photographs of preserved specimens, reconstructed CT and photogrammetry 3D models, xrays, characteristics for...

floridamuseum.ufl.edu

So proud to have “Early-life stress alters H3K4me1 in VTA to prime stress sensitivity” out now in Neuron! This work spanned Many years and Many people contributed. Huge thanks to @hyejaykim.bsky.social, @ja-balouek.bsky.social, Luke Geiger, and Meaghan Creed www.cell.com/neuron/fullt...

Early-life stress alters H3K4me1 in VTA to prime stress sensitivity

Kim, Geiger et al. report that early-life stress increases the chromatin modification H3K4me1 and its enzymatic writer, SETD7, in the ventral tegmental area. They show that this form of epigenetic pri...

cell.com

🚨 Now available on Nature Careers ! #Recruitment #Ottawa

Tier 2 Canada Research Chair in Vascular Links to Neurodevelopment - Ottawa, Ontario (CA) job with University of Ottawa, Ontario CANADA | 12861923

uOttawa, in partnership with the OHRI, invites applications for a Tier 2 CRC in Vascular Links to Neurodevelopment and their impact on brain health.

nature.com

We are hiring! Are you an ambitious postdoc with a background in vascular bioengineering and cell biology? Then please join our team at Amsterdam UMC and help unravel the mechanisms that govern vascular integrity. #embobuildnetworks #vascularbiology #EVBO werkenbij.amsterdamumc.org/en/vacatures...

Vacatures - Postdoc Vascular Biology - Amsterdam UMC

Are you an ambitious scientist with a background in vascular bioengineering and cell biology? Join our team at Amsterdam UMC and help unravel the mechanisms that govern vascular integrity.

werkenbij.amsterdamumc.org

“The whole point of AI tools is that I no longer need to retain information in my biological memory. My biological memory is for other things now. Important things. Like my Netflix password” 😂 inpreparation.substack.com/p/opinion-i-...

Opinion: I Was Not Allowed To Type Prompts Into ChatGPT During My Chalk Talk And This Is Discrimination

By Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University

inpreparation.substack.com

Registration and Abstract submission for the 2026 Canadian Lipid and Vascular Summit (Edmonton Chapter) is open! clvsummit.ca

The #ThermoFisher #antibody scandal is an ugly reminder, I think, of how few people (including those at TF, it seems) are trained to properly validate antibodies before use. Some advice on antibody validation in the posting 👇 totalinternalreflectionblog.com/2022/09/18/h...

Hitting the target (a short guide to validating antibody specificity)

Antibodies are essential and ubiquitous tools in biology, but their unguarded usage can easily lead to error. Here’s how to validate their specificity, and ensure that they’re hitting the rig…

totalinternalreflectionblog.com

Reese Richardson@reeserichardson.bsky.social · 4mo ago

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

Beautiful paper from Andrew Yang’s group. A whole suite of new tools for studying brain waste clearance. A few take home points: www.cell.com/cell/fulltex...

Physiological brain clearance architecture revealed by neuronal protein tracing

Neuronal protein tracing, unlike CSF tracers, reveals that brain clearance follows a “nearest exit” principle through distinct border immune niches disrupted differently by disease.

cell.com

Hi everyone! I am a PhD student in virology and I built a completely free iOS app in my free time. Please try it, any feedback is welcome! A repost would help more scientists see it. 📱 apps.apple.com/us/app/cell-... #Biology #PhD #AcademicSky #scicomm #virology #LabLife

Cell Culture and Lab Assistant App - App Store

Download Cell Culture and Lab Assistant by Umut Tank on the App Store. See screenshots, ratings and reviews, user tips, and more apps like Cell Culture and Lab…

apps.apple.com

If you are looking for a useful free app for your lab, check this apps.apple.com/us/app/cell-... Developed by Umut Tank, a PhD student in Germany as a fun side project!

Cell Culture and Lab Assistant App - App Store

Download Cell Culture and Lab Assistant by Umut Tank on the App Store. See screenshots, ratings and reviews, user tips, and more apps like Cell Culture and Lab…

apps.apple.com

SAVE THE DATE for the 13th Canadian Developmental Biology Conference — March 7–10, 2027 — bringing together researchers, trainees, and innovators in developmental biology from across Canada and beyond.

Why do guinea pigs have so many natural bypass arteries — and mice and humans almost none? We develop in vivo Perturb-seq for endothelial cells to ask how protective collateral arteries are built. Preprint with by Irene Fan, Ronghao Zhou, and Kristy Red-Horse: www.biorxiv.org/content/10.6...

🚨 New preprint on bioRxiv! Pericyte loss triggers hypoperfusion, BBB dysfunction, endothelial VCAM-1/type I IFN activation, venular-like transitions & delayed white matter injury linked to human SVD signatures. Congrats Dr. Dorota Stefancova & team! www.biorxiv.org/content/10.6...

🚨WE ARE HIRING🚨 Interested in regeneration? cardiac development? just like doing zebrafish research? Join us in beautiful Montreal! Check here if interested www.izfs.org/jobboard/ame... @zebrafishrock.bsky.social @isrbio.bsky.social @izfs.bsky.social