The ‘missed disease’ that affects 190 million: endometriosis drug shows early promise

Modified medication targets the cells implicated in the condition’s tell-tale lesions.

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Building clinical translation on squares of discovery - Nature Reviews Immunology

Why do so many promising immunotherapies fail to reach their potential? Adrian Hayday argues that transformative clinical advances depend on protecting specialized ‘squares of discovery’ in which deep...

nature.com

Intratumoral Bacillus cereus orchestrates stem-like lymphoid niches to potentiate immunotherapy response in hepatocellular carcinoma

Hu et al. integrate spatial multi-omics to identify stem-like lymphoid niches (SLNs) organized by CD70+ ILC2s and Tpex cells that predict PD-1/PD-L1 immunotherapy responses in hepatocellular carcinoma (HCC). They reveal that Bacillus cereus-PI-PLC increases SLN abundance and synergizes with PD-L1 blockade, highlighting microbiota-driven enhancement of cancer immunotherapy through SLNs therapeutically in HCC.

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Starved of oxygen and fueled by macrophages: Path to progression in RCC

In this issue of Cancer Cell, Vuong et al. perform a cross-species functional and molecular analysis of the mechanisms of response and adaptation to VEGFR kinase inhibitors and immunotherapy, identifying SPP1+ tumor-associated macrophages as key players of response to therapy. They further demonstrate that chronic treatment promotes metastatic spread.

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A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma

Rade et al. present a longitudinal single-cell atlas of BCMA CAR-T therapy in multiple myeloma, revealing that cilta-cel drives potent CD4⁺ cytotoxic responses and superior outcomes. Their findings identify plasmacytoid dendritic cells as unexpected BCMA-expressing targets and suggest therapeutic potential in blastic plasmacytoid dendritic cell neoplasm.

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Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis

Rheumatoid joints contain macrophages with reparative potential, yet inflammation persists. Huang et al. demonstrate that these homeostatic macrophages lose their protective role by undergoing PANoptotic death. Mechanistically, C1q activates the mitochondrial enzyme SARM1, driving NAD⁺ cleavage into cADPR, which precipitates metabolic collapse and PANoptosis. The resulting macrophage death amplifies autoimmune tissue inflammation through the release of pro-inflammatory mediators.

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Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 - Nature Cell Biology

Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

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A scalable, low-cost, sample hashing workflow for multiomic single-cell analysis using the Seq-Well S3 platform

Nature Protocols, Published online: 06 March 2026; doi:10.1038/s41596-025-01308-8This Protocol presents a detailed guide for generating and analyzing single-cell multiomic data from low-input samples with the Seq-Well S3 platform.

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Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics - Nature Methods

This work presents SUM-seq, an ultra-high-throughput method for co-profiling chromatin accessibility and gene expression in single nuclei across multiplexed samples, advancing the study of gene regula...

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Researchers praise ‘stunning’ results of new prostate cancer treatment

Early trials of the drug VIR-5500 showed it shrinking tumours in some patients

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A multimodal imaging pipeline to decipher cell-specific metabolic functions and tissue microenvironment dynamics - UCL Discovery

UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.

discovery.ucl.ac.uk

Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage

Li et al. show that SPOP mutations and USP7 overexpression promote TREX1 upregulation, leading to increased cytosolic DNA degradation and suppression of cGAS-STING-mediated immune activation. Targeting USP7 enhances the effectiveness of radiotherapy combined with immune checkpoint blockade, providing a new strategy to overcome resistance and improve therapy outcomes.

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Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity

Commensal microbes shape host immunity at barrier tissues and promote resistance to infection. Xu et al. identify a commensal Corynebacterium-derived lipid that activates IL-17⁺ γδ T cells via T cell receptor and IL-1 signaling, enhancing barrier defenses. This finding highlights the translational potential of a microbe-informed therapeutic strategy at barrier surfaces.

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How Does Immunotherapy Help Us Treat Cancer? – with Samra Turajlić

YouTube video by The Francis Crick Institute

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Polyamine-dependent metabolic shielding regulates alternative splicing - Nature

Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.

nature.com