The AJP-Lung editorial fellowship is inviting applications for a new round: ow.ly/rUAN50Zq10K I really enjoyed and benefitted from participating - more info in this article from previous fellows: doi.org/10.1152/ajplung.00251.2026

A query for the immunologists: Are there any PAMPs left to discover?

Are tapes a good option for long-term cold storage of microscopy data? I'm looking at storing ~200 TB with no recurring fee (no cloud) and with as little esoteric server/command line fuss as possible www.ibm.com/fr-fr/produc...

Great to see our new paper out in Nature Communications. In it we describe three novel phenotypes in lungs of patients with pneumonia. Pn1 -a non-neutrophil driven lung injury phenotype, Pn2-a balanced immune response with best recovery and Pn3-persistent inflammation driven by immature neutrophils

Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes

Nature Communications - Analysis of cell samples from pneumonia patients may indicate specific phenotypes associated with disease. Here the authors use a multi-omics approach to analyse...

rdcu.be

Read about how research into lymphatic function is changing our understanding of immune regulation in the lungs in our review: doi.org/10.1016/j.co... Congratulations to co-authors Amy Rivers and Camila Migues Ramirez!

We present: Index-agnostic oblique plane light sheet microscopy of centimetre-scale cleared tissues at subcellular resolution www.biorxiv.org/content/10.6...

UK-based cell biologist? Interested in membrane trafficking? Want to find a conference? Looking for a job (PI, postdoc...)? Do link to www.ukmembranetraffic.com, where @jezcarlton.bsky.social and Chris Stefan (not here?) do sterling work

Sad to hear of the loss of Richard Lehman. Grateful to him and @raj-mehta.bsky.social for recording this podcast - an excellent teaching resource: creators.spotify.com/pod/profile/...

Mary Dixon-Woods@marydixonwoods.bsky.social · 3mo ago

I’m very sorry to hear the great Richard Lehman has died. He brought clarity and wit to his work, including his wonderful BMJ column, and never stopped caring about patients long after he stopped being a GP. He will be very much missed.

Happy to share that our latest work on VEGFR2 in lymphatic endothelium is published @natcomms.nature.com “VEGFR2 is required for VEGF-C–VEGFR3–PI3Kα-mediated sprouting lymphangiogenesis” tinyurl.com/47bns9pp This project has been a long journey for the lab @taijamakinenlab.bsky.social , A thread.

🔬 PhD position at Imperial College London! Uncover how pericytes, mysterious vascular cells, drive asthma inflammation. Use spatial transcriptomics, 3D imaging & transgenic models to unlock new therapies. 3-year funded PhD | Oct 2026 start 👉 www.findaphd.com/phds/project... 📧r.joulia@imperial.ac.uk

Defining the Immune Functions of Lung Pericytes and Their Dysregulation in Asthma at Imperial College London on FindAPhD.com

PhD Project - Defining the Immune Functions of Lung Pericytes and Their Dysregulation in Asthma at Imperial College London, listed on FindAPhD.com

findaphd.com

Happy #FluorescenceFriday. I feel so lucky to get to work with these weird and curious primary macrophages from 🐸. They exhibit myriad different morphologies and behaviours, including spinning endlessly and stationary, kinda like progenitor cells under compression from 🐟. Also actomyosin is strong!

Great to see how this research into mechanisms of neutrophil-assisted breast cancer metastasis has developed! Updates summarised in a postlight: doi.org/10.1242/prel... @prelights.bsky.social

Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer - preLights

Pre-metastatic neutrophilia and lung-metastatic breast cancer: a one-two punch to the lungs

doi.org

Leo Carlin@bair-head.bsky.social · 5mo ago

Excited to share our latest work lead by Fred Fercoq and Gemma Cairns. Huge thanks to @breastcancernow.bsky.social and amazing colleagues for making it possible. www.cell.com/cell-reports...

Thrilled to share the first paper from the lab, out now in Molecular Cell! A wonderful collaboration with @thurstonlab.bsky.social bridging Salmonella host-pathogen interactions and regulatory genomics - two of my favourite things in one story. www.cell.com/molecular-ce... 🦠 🧵1/10

Salmonella effector SteE reprograms the macrophage regulatory network to drive specific hyperactivation of STAT3 target genes

Diaz-del-Olmo et al. reveal how a Salmonella virulence protein alters the transcriptional layout of infected macrophages through hyperactivation of a transcription factor and coordinated chromatin rem...

cell.com

Thank you to all the fantastic students, supervisors, co-organisers and advisors who took part in this (very) oversubscribed Summer Studentship scheme. Delighted that it has opened doors for the students involved!

Royal Microscopical Society@royalmicrosoc.bsky.social · 4mo ago

Our latest issue of infocus Magazine #RMSinfocus highlights the excellent @bioimaginguk.bsky.social and @physicsoflifeuk.bsky.social Summer Studentship scheme - providing opportunities to students from low-income backgrounds. Download the article: www.rms.org.uk/resource/ope...

After a negative decade - finally a good year for IPF patients - Inhaled Treprostinil associated with a smaller decline in FVC & fewer clinical-worsening events (but also ~30%). Still no improvement - but let’s all hope momentum continues #CurePF4ALL www.nejm.org/doi/full/10....

Inhaled Treprostinil for Idiopathic Pulmonary Fibrosis | NEJM

Preclinical data indicate that inhaled treprostinil may be useful for the treatment of idiopathic pulmonary fibrosis (IPF) through an antifibrotic mechanism, a premise that is supported by clinical...

nejm.org

Do we study the right biology after myocardial infarction (MI)? • Surgery in standard mouse model disrupts bone marrow & masks MI-specific immune responses • Minimally invasive model better reflects patient immune responses & reveals immature neutrophils worsen heart function tinyurl.com/MImodels

This was so fun! Thank you so much to @cindyleifer.bsky.social and @microbetv.bsky.social for the opportunity to discuss pregnancy immunology ✨

Microbetv@microbetv.bsky.social · 5mo ago

@cindyleifer.bsky.social talks with Gabrielle Rizzuto from Memorial Sloan Kettering Cancer Center about her work on the curious immunology of pregnancy and how a woman tolerates a genetically different baby but quickly rejects a mismatched organ donation.

Ok pals. Looking to move all my teaching materials open and online, and am developing new modules that I want to start off this way. Content = reading, quizzes, videos, and code tutorials. Opinions on the best platform? Good examples of best practice I can steal from? Many thanks.

Few but mighty - check out this cool study implicating gamma delta T cells in controlling macrophage responses in lung cancer!

Leo Carlin@bair-head.bsky.social · 5mo ago

Delighted to share our latest paper, led by Dr Ximena Raffo-Iraolagoitia, just published in Science Advances! www.science.org/doi/10.1126/...

1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...

@simoncleary.bsky.social, Longhui Qiu, Mark Looney et al. developed a new #intravital technique for imaging pulmonary lymphatics. rupress.org/jem/article/... 📘 In our #Lymphatics collection: rupress.org/jem/collecti...

Happy to share a write-up of our recent publication @natcomms.nature.com demonstrating how circumferential actomyosin-driven endothelial cell contractions constrict vessel diameter, providing insights into mechanisms of normal vessel remodelling and CCM. www.bdr.riken.jp/en/news/rese...

When vessel constriction fails: Cellular mechanics linking developmental remodeling to vascular malformations

bdr.riken.jp

The rules of immunity are different in early life! Lead author Dr. Yue Xing finds that early life DCs sense allergens and trigger inflammation directly in skin. This in-situ activation state emerges from a developing HPA and low glucocorticoids. #Naiklab @nature.com www.nature.com/articles/s41...

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation - Nature

Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to allergens in later l...

nature.com

www.biorxiv.org/content/10.6... Excited to share our new preprint: Not all microglia are the same. In this study, we identify a specialized ApoE-dependent program in the median eminence positioning microglial lipid metabolism as a driver of hypothalamic adaptation to nutritional stress.

I am looking for an Illustrator to help with making schematics and diagrams. Might anyone guide me on who to contact? Thanks #science #Illustration #Academia

Cool to see data backing up an anecdote I have been told - that short (1 hour) formaldehyde fixation can be better than longer (6 hours+) fixation for staining some antigens:

bioRxiv Immunology@biorxiv-immuno.bsky.social · 6mo ago

Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualisation in epithelial tissues https://www.biorxiv.org/content/10.64898/2026.02.13.705745v1

Anyone ever tried super glue (cyanoacrylate) for mounting coverslips with stained mammalian cells, to be used for fluorescence microscopy? I'm looking for ways to conserve microscopy samples for a looooooong time...

Too much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @Yale www.nature.com/articles/s41...

On the balance of knowledge - Nature Reviews Immunology

Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

nature.com

Useful article addressing an often-overlooked way in which research impacts the environment:

Thiago Carvalho@cyrilpedia.bsky.social · 6mo ago

'This initiative encourages staff to delete unnecessary data and improve data management, thereby lowering the environmental impact of data storage. We present a roadmap with 11 quick tips (Fig 1) for organizing a data cleaning challenge within any organization.' journals.plos.org/ploscompbiol...

Good news!! Oral Nalbuphine reduces cough count baseline by ~50 % in Idiopathic Pulmonary Fibrosis–Associated Cough jamanetwork.com/journals/jam...

Oral Nalbuphine in Idiopathic Pulmonary Fibrosis–Associated Cough

This randomized clinical trial examines the safety and efficacy of oral nalbuphine in patients with chronic cough caused by idiopathic pulmonary fibrosis.

jamanetwork.com