@sverregr.bsky.social
1/ 🚨🚨Preprint alert! "Perfect" isn't always smart 🧠. Anyone can tell apart two stimuli (including our mice). But how do we extract rules that apply to new stimuli? 🧵 biorxiv.org/content/10.6... @marius10p.bsky.social @computingnature.bsky.social #neuroAI #neuroscience #AI
🚨🧠 Our paper is out! We introduce a simple computational model that generates macroscopic, long-timescale dynamics as seen in large-scale neural recordings. #neuroscience #dynamics @marius10p.bsky.social @zhong-lin.bsky.social @hhmijanelia.bsky.social Link: go.nature.com/4tRNjIu
Nature@nature.com · 3mo agoNature research paper: A critical initialization for biological neural networks go.nature.com/4tRNjIu
🚨 Ever wanted a simple way to control the activity of thousands of neurons? We introduce an all-optical raster photostimulation method to do just that! w/ @computingnature.bsky.social @marius10p.bsky.social #FluorescenceFriday #neuroskyence www.biorxiv.org/content/10.6... 1/n
Long-term editing of brain circuits using an engineered electrical synapse www.nature.com/articles/s41... - this is wild, from Kafui Dzirasa and colleagues!
Long-term editing of brain circuits using an engineered electrical synapse - Nature
Connexin proteins found in white perch fish were used to engineer synthetic electrical synapses, enabling precision circuit editing in mammals.
nature.com
The footsteps illusion-like pausing and sticking illusion The rectangles in the upper half appear to move to the right and stop periodically; however, they are moving to the right at a constant speed in the same way as the rectangles in the lower half.
I always assumed that brain function had to line up with cytoarchitectonics. It turns out I was wrong. Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams. www.biorxiv.org/content/10.6...
1/ 97% of cortical PNNs are on PV interneurons. But PNN-positive and PNN-negative PV cells don't split into two groups — they sit at different ends of a transcriptional continuum of fast-spiking specialization. New preprint 🧵
I'm very excited to finally see this one out in @natneuro.nature.com ! It has been an incredible journey alongside extremely talented people! Thanks to everyone involved and enjoy the reading! 1/n www.nature.com/articles/s41...
Position-independent emergence of neocortical neuron molecular identity, connectivity and function - Nature Neuroscience
Even when neocortical neurons form in abnormal locations, they retain their identity and function, revealing that brain circuit formation can be guided by intrinsic developmental programs rather than ...
nature.com
What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...
Just published my review of neuroscience in 2025, on The Spike. The 10th of these, would you believe? This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more Enjoy! medium.com/the-spike/20...
2025: A Review of the Year in Neuroscience
Enlightening the brain
medium.com
✨ New preprint ✨ What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our work introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡 www.biorxiv.org/content/10.1... 1/13 🧵
Large-scale cellular-resolution read/write of activity enables discovery of cell types defined by complex circuit properties
The complexity of the mammalian brain’s vast population of interconnected neurons poses a formidable challenge to elucidate its underlying mechanisms of coordination and computation. A key step forwar...
biorxiv.org
Our paper on 'mini analysis' is now published in @jphysiol.bsky.social If you are recording mPSCs or sPSCs, I hope this helps with analysis. Interpretation of these datasets is not as easy as it seems..! Happy to discuss if you are interested physoc.onlinelibrary.wiley.com/doi/10.1113/...
‘Mini analysis’ misrepresents changes in synaptic properties due to incomplete event detection
Abstract figure legend Summary of the study where simulated recordings (left) were used to characterise the effect of incomplete detection on mini (mPSC) analysis. Recording noise levels (red) determ...
physoc.onlinelibrary.wiley.com
Does predictive coding work in SPACE or in TIME? Most neuroscientists assume TIME, i.e. neurons predict their future sensory inputs. We show that in visual cortex predictive coding actually works across SPACE, just like the original Rao+Ballard theory #neuroscience www.biorxiv.org/cgi/content/...
🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸♀️. Try it now on 🤗 huggingface.co/spaces/mouse... paper: www.biorxiv.org/content/10.1... w/ @computingnature.bsky.social 1/n
New paper out with @hafting.bsky.social and @markandermann.bsky.social lab on reactivations and memory consolidation : www.science.org/doi/10.1126/...
Local inhibitory circuits mediate cortical reactivations and memory consolidation
Reducing inhibitory activity after training prevents cortical reactivations and memory consolidation.
science.org
We previously showed that specific hypothalamic neurons get more and more activated by each bite of food until they put a brake on homeostatic feeding. Here, we find that this brake is already on at the start of a meal in obese mice on a high-fat diet. Congrats to Marta, Stephen and the whole team!
Marta Porniece@martaapp.bsky.social · last yr.🚨 Paper alert! 📣 We found abnormal feeding-related neural responses in satiety-promoting, MC4R-expressing neurons in the mouse paraventricular hypothalamus (PVH-MC4R) following diet-induced obesity. www.biorxiv.org/cgi/content/... #obesity #feedingbehaviour #obesityresearch #neuroscience
New preprint out in eLife! Neurons in medical entorhinal cortex (MEC) develop responses to visual cues and reward as mice learn a visual Go/NoGo task. elifesciences.org/reviewed-pre...
Like every year, our lab plans to attend the @sfn.org meeting in the US. But is it safe to go? This scientist was sent back (as confirmed by @lemonde.fr, no less). Other visitors were recently detained by ICE goons for days. It feels risky. See y'all at FENS in Barcelona? www.fens.org
Federation of European Neuroscience Societies - The voice of European neuroscience, representing more than 20,000 European neuroscientists
fens.org
Chelsea G. Summers@chelseagsummers.bsky.social · last yr.So on March 9, a French scientist, on a visa to attend a conference in Houston, was denied entry to the US and subsequently expelled because his phone had messages decrying scientific policies put forward by the Trump administration: www.lemonde.fr/internationa...
Thalamic opioids from POMC satiety neurons switch on sugar appetite www.science.org/doi/10.1126/... - or why we crave dessert, even when we're full! 🍰🍨
Thalamic opioids from POMC satiety neurons switch on sugar appetite
High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the n...
science.org
delighted to share our work revealing a new type of excitatory hippocampal neuron we call the "ovoid cell", which has really exquisite properties relative to adjacent pyramidal cells! superb work of first-author @adriennekinman.bsky.social and many others in the lab www.nature.com/articles/s41...
Atypical hippocampal excitatory neurons express and govern object memory - Nature Communications
Pyramidal cells are classically thought to comprise the excitatory output of the subiculum. Here, the authors show the existence of “ovoid cells”, excitatory subiculum neurons with specialized gene ex...
nature.com
1/12 How do animals build an internal map? In our new paper, we tracked thousands of mouse CA1 neurons over days/weeks as they learned a VR navigation task. @nspruston.bsky.social & co-1st author @johanwinn.bsky.social Video: www.youtube.com/watch?v=yw_4... Paper: www.nature.com/articles/s41...
Learning produces an orthogonalized state machine in the hippocampus
YouTube video by Weinan Sun
youtube.com
A little challenge for neuro/cog sci (/psych/comp-sci/bio/philosophy!) blueys: How would you define "cognition"?
🎄PinkyCaMP- our christmas gift to you! 🎁: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with: ✨exceptional, brightness ✨phototability ✨and optogenetic compatability. Check out our new preprint: www.biorxiv.org/content/10.1...
OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019). The renamed: Bluesky-sized history of neuroscience (biased by my interests)
Together with some friends we built an optical Brain Machine Interface to see if cortical activity (PPC) can control behaviour in real time, without animals having to learn to use it. Here's what happened: www.biorxiv.org/content/10.1...
biorxiv.org
In collaboration with Reuben Saunders, @jswlab.bsky.social, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! www.biorxiv.org/content/10.1...
A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function
Organ function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the...
biorxiv.org
