Tom Riffelmacher
@tom-riffel.bsky.social
Professor; University of Cologne; We research Immunometabolism, unconventional T cells, and cardio-oncology.
🚨New paper alert!! Out in @insight.jci.org - highlights defects in Vdelta2 T cells in people living with obesity. Importantly we can see bariatric surgery restores these cells!! Led by @ciara.l.flynn but it takes a village. Thanks to funding from HRB. Find it here doi.org/10.1172/jci....
doi.org
We are recruiting a technician! Wir haben eine BTA Stelle in Köln offen. jobs-uk-koeln.onlyfy.jobs/en/job/uf1bu...
Biologisch-technische/r Assistent/in / BTA (w/m/d)
Zur Unterstützung unseres stark wachsenden Teams suchen wir zum nächstmöglichen Zeitpunkt: Biologisch-technische/r Assistent/in / BTA (w/m/d) Innere Medizin - AG Riffelmacher TV-L 38,5 Std./Woche zunä...
jobs-uk-koeln.onlyfy.jobs
Very cool new study from Wendy Garrett's lab: Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit. www.sciencedirect.com/science/arti...
Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit
The efficacy of immune checkpoint inhibitors (ICIs) in colon cancer (CC) is limited by the tolerogenic immune landscape of both the tumor and the inte…
sciencedirect.com
Delighted to see over review and concept on the cover of this month's @cp-trendsendomet.bsky.social where we cover GLP-1s & SGLT2i as anti-inflammatory agents- co-authored with @nickjonesimmuno.bsky.social
Seeking a junior scientist for scRNA-seq analytics in Cologne or remotely. If terms like Seurat, DimPlot, or ggplot2 spark recognition—or curiosity—you might be a fit.Flexible $$ Contract, Part time, MSc-to-PhD transition, or PhD project possible. Please feel free to reach out: triffelm@uni-koeln.de
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
A bit like spiralling publication costs we need to start having a proper discussion around lab equipment servicing costs. These are often completely disproportionate to the cost of instrument and the service that is provided and seem to serve as a cash cow for vendors.
Awesome science creativity podcast @nightsciencepod.bsky.social
Itai Yanai@itaiyanai.bsky.social · last yr.'Both competition and cooperation' – that is an underlying principle of how Google designed its "AI co-scientist" platform to generate ideas and think like a scientist. We talk with the leaders of this project on the latest episode of the Night Science Podcast. @nightsciencepod.bsky.social
Review @natrevimmunol.nature.com Metabolic control of innate-like T cells www.nature.com/articles/s41...
"Immunometabolism, the intersection of cellular metabolism and immune function, has revolutionized our understanding of T cell biology." LJI experts share key discoveries from the growing field of immunometabolism! 👇 #Tcells #Cd1Mr12025
Tom Riffelmacher@tom-riffel.bsky.social · last yr.Just in time for #Cd1Mr12025 Our Review on Innate-like T cell Metabolism is out! Access free here: rdcu.be/eEV67 Please share with your Immunometabolism friends! @cd1mr1.bsky.social @lji.org @uniklinikkoeln.bsky.social @natureportfolio.nature.com @natrevimmunol.nature.com
Just in time for #Cd1Mr12025 Our Review on Innate-like T cell Metabolism is out! Access free here: rdcu.be/eEV67 Please share with your Immunometabolism friends! @cd1mr1.bsky.social @lji.org @uniklinikkoeln.bsky.social @natureportfolio.nature.com @natrevimmunol.nature.com
Metabolic control of innate-like T cells - Nature Reviews Immunology
Functional and metabolic properties of innate-like T cells — namely, iNKT cells, MAIT cells and some γδ T cells — differ from those of conventional T cells. This Review describes how metabolic pathway...
nature.com
Horisberger et al separate Lupus nephritis patients in 3 groups by blood: healthy-like, interferon-dominant and CD8 T cell-dominant. The CD8 T cell-dominant group had the highest biopsy activity score and highest response rate after 1 year; the healthy-like the most chronic damage. 🧪 ⑂ #NephSky 1/
In this #TopRead article, data demonstrated that TNFR family member CD27 is a metabolic regulator in activated human CD4+ cells, suggesting its essential contribution to T-cell metabolism and its relevance as a therapeutic target. Read more in The JI: ow.ly/bCJk50WJAwi.
First session featuring our DGfI study groups ✅ covering innate immunity, autoimmunity, solid tumor immunology, trained immunity and CNS. Much food for thought and discussion during the coffee break☕☕☕ #IUIS25 @dgfi-org.bsky.social
Bittersweet farewell weeks at @kiroxford.bsky.social, a place pivotal to my growth as an independent scientist. With deep gratitude for this chapter, I'm thrilled to begin the next at @unibas.ch @biomedizin.unibas.ch, where my lab will study organelle inheritance in T cells in the context of ageing.
Kennedy Institute of Rheumatology@kiroxford.bsky.social · last yr.Dr Mariana Borsa (@nanaborsa.bsky.social), a postdoc studying autophagy and ageing, will leave the Kennedy Institute to start an exciting new chapter in Switzerland as a Principal Investigator!! 🎉 www.kennedy.ox.ac.uk/news/dr-mari...
MTA/BTA Stelle zu besetzen bei uns im lab! Join us!
In diabetic retinopathy, microvascular damage & inflammation disrupt the blood-retina barrier, but the role of microglia was unclear Thomas Langmann & team now show suppression of microglia-driven inflammatory responses preserves retinal integrity. buff.ly/2k5pD5W
This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥 www.nature.com/articles/s42...
The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism
This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
nature.com
Very cool! www.journal-of-hepatology.eu/article/S016...
Polyunsaturated fatty acid-induced metabolic exhaustion and ferroptosis impair the anti-tumour function of MAIT cells in MASLD
Mucosal-associated invariant T (MAIT) cells constitute a highly abundant innate-like T cell population in the human liver that is critical for immune surveillance of hepatic cancers but often dysfunct...
journal-of-hepatology.eu
Forget Trump & Musk's bromance...join us at Keystone's Immunometabolism Across Scales: From Cells to Systems to Healthspan! Super science, discussions and colleagues. Be there- Vancouver, BC Jan 11-14, 2026. Keynotes: Amazing Drs. Dana Pe'er and Marcia Haigis!! Speaker line-up is GOAT!
We also see a surge of postdoc applications of highly qualified scientist who normally would pursue their work in the US
Reuters@reuters.com · last yr.Max Planck Society sees flood of US job applicants amid Trump swoop on universities reut.rs/45uYNZR
A huge congratulations to LJI's Dr. Tom Riffelmacher! Tom's work has helped reveal a whole new side of T cells, and we are thrilled to see what he does next! 🎉
Tom Riffelmacher@tom-riffel.bsky.social · last yr.I am not dreaming, it’s official! I am starting my lab as Professor in the department of medicine III at @unicologne.bsky.social We will explore the immunometabolic control of unconventional lymphocytes in cancer and cardiovascular disease. WE ARE HIRING AT ALL LEVELS (MTA/BTA, postdoc, PHD)
With nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive
I am not dreaming, it’s official! I am starting my lab as Professor in the department of medicine III at @unicologne.bsky.social We will explore the immunometabolic control of unconventional lymphocytes in cancer and cardiovascular disease. WE ARE HIRING AT ALL LEVELS (MTA/BTA, postdoc, PHD)
I'd like to share this short piece on a topic I hope you will find useful. It is the result of a personl journey and many discussions with friends and peers. Let me know your thoughts. network.febs.org/posts/the-pr...
The Professional Self: The Enemy Inside
network.febs.org
I am honored to be part of the Gates foundation research consortium on unconventional T cells and grateful for their support.
Reuters@reuters.com · last yr.Bill Gates said the world's poorest would receive some $200 billion via his foundation as he pledged to give away almost his entire personal wealth in the next two decades, at a time when governments worldwide are slashing international aid reut.rs/3StcPn2
Great time catching up with friends from near and far, and making new ones at HawAAI #AAI2025 #IMMUNOLOGY2025
