Tissue-specific aging clocks map structured aging-modulatory drug-score patterns across 49 human tissue and cell-line categories - Biogerontology

Aging clocks are typically trained on pooled multi-tissue data, implicitly assuming that aging is uniform across organs. Here we challenge this assumption by constructing 49 transcriptomic clocks acro...

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From memory clinics to Brain Health Services: implications for older adults and the future of cognitive care in Europe

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Clinical factors associated with retreatment and early coronary outcomes in Kawasaki disease in children aged < 6 months: a single-center cohort study - PubMed

• In this infant-only cohort, pre-treatment CAA Z-score ≥ 2.5 and neutrophil-to-lymphocyte ratio ≥ 2.15 were associated with additional IVIG. • Pre-treatment CAA Z-score, lower albumin, and an early r...

pubmed.ncbi.nlm.nih.gov

Pacing strategies in Gran Fondo cycling: a large-scale analysis of the Quebrantahuesos race - Sport Sciences for Health

Purpose Pacing is a key determinant of endurance performance, yet pacing behavior in mass-participation Gran Fondo cycling events remains insufficiently described. The objective of this study was to e...

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Associations of length of stay with sarcopenia parameters in geriatric patients: age and sex differences in the oldest old - Aging Clinical and Experimental Research

Background Hospital-associated deconditioning is a contributor to secondary sarcopenia, which may be driven by prolonged hospital length of stay (LoS). This study investigated the bidirectional associ...

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Aging in Behçet's syndrome: an overlooked risk for late-life cognitive impairment - PubMed

Behçet's syndrome (BS) is a chronic multisystemic inflammatory disorder with a heterogeneous clinical course. A severe subset with central nervous system involvement (neuro-Behçet's syndrome, NBS) car...

pubmed.ncbi.nlm.nih.gov

Pleiotropy and disease interactors: the dual nature of genes linking ageing and ageing-related diseases - Biogerontology

Ageing-related diseases (ARDs) display diverse phenotypes yet share an age-dependent rise in incidence, suggesting mechanistic links with ageing processes. We examined whether ageing-related genes dif...

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Ageing was never a singular problem in biology: implications for mechanisms, measurements and interventions - Biogerontology

Biological ageing is often approached through its underlying mechanisms and their therapeutic potential. Yet age-related decline arises from multiple processes shaped by evolutionary constraints and f...

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Remote sensing across scales and platforms: monitoring Castelporziano nature reserve forest insect outbreaks - Rendiconti Lincei. Scienze Fisiche e Naturali

Stone pines (Pinus pinea) are a dominant species in Mediterranean coastal forests, playing a crucial ecological and landscape role. However, these ecosystems are experiencing increasing pressure from rising temperatures, prolonged droughts, and other stressors, which weaken trees and make them more susceptible to natural disturbances, such as insect infestations, leading to significant forest decline. This study presents a multi-platform, temporal, and spatial resolution remote sensing approach to detect and monitor insect outbreaks. The study area is Castelporziano Presidential Estate (Rome, Italy), a pine-dominated periurban forest of high ecological value and severely affected by Tomicus destruens (Coleoptera: Curculionidae) and Toumeyella parvicornis (Hemiptera: Coccidae). Very high-resolution Pléiades and DigitalGlobe images were used to map forest disturbances accurately and to assess the accuracy of the yearly forest disturbance maps obtained through Sentinel-2 data. Sentinel-2 data enabled the production of yearly disturbance maps in near real time (NRT), improving the Three Indices Three Dimensions (3I3D) unsupervised forest disturbance algorithm. Lastly, PlanetScope data were used to calculate the Mean Time Lag (MTL) between disturbance occurrence and detection in Sentinel-2 NRT images, revealing an average detection delay of 8.5 days. Additionally, the unsupervised model’s performance was evaluated, yielding an overall accuracy of 85%. The accuracy of the Sentinel-2 forest disturbance map was assessed against the map derived from Pléiades/DigitalGlobe, achieving an overall accuracy of 92%. These findings confirm that integrating multi-source remote sensing data enhances the timeliness and reliability of insect outbreak monitoring, offering valuable tools for managing Mediterranean forests threatened by climate change and biotic agents. Graphical Abstract

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Recommendations from the European interdisciplinary council on ageing on physical activity and diet for mental health conditions in older adults - Aging Clinical and Experimental Research

The global rise in life expectancy is accompanied by an increase in the prevalence of mental health conditions among older adults, including mild cognitive impairment (MCI), dementia, delirium, depres...

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Environmentally friendly pediatric gastroenterology: a narrative review - European Journal of Pediatrics

Medical care might be highly resource-intensive, with a significant contribution to greenhouse gas emissions and waste generation. This narrative review aims to provide a synopsis of the current evide...

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Association of supine versus seated hypertension with cardiovascular events in older adults - European Geriatric Medicine

Purpose Supine hypertension is prevalent but underdiagnosed among older adults, and its relationship with cardiovascular risk in adults aged ≥ 65 years remains unclear. This study aims to investigate ...

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Client Challenge

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Client Challenge

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Single-center study of vancomycin treatment in children with infection: influencing factors of plasma trough concentration and assessment of clinical effectiveness - PubMed

Achieving optimal vancomycin trough concentrations in vivo is crucial to its therapeutic effectiveness. This study was a retrospective, single-center, observational cohort analysis designed to further...

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eHealth in geriatric rehabilitation: an international consensus study

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Are we making progress in the diagnosis and management of sarcopenia? Results from a UK-wide survey - European Geriatric Medicine

Purpose To describe current practice in diagnosis and management of sarcopenia in older people in the United Kingdom (UK). Methods Healthcare professionals from UK organisations were invited to complete an online survey about sarcopenia diagnosis and management. Results One hundred and one responses were analysed. Respondents represented a range of professional groups across 62 organisations from secondary care, primary care, community providers and private practitioners. Sarcopenia was identified in only 32/62 (52%) organisations. Within these organisations, 17/32 (53%) did not use a recognised algorithm for diagnosis, although 31/32 (97%) of organisations assessed muscle strength. Twenty-nine (91%) organisations reported offering interventions to people diagnosed with sarcopenia, but resistance training was offered by only 19 (59%). Conclusion This survey has shown that just over 50% of respondent organisations in the UK are identifying sarcopenia in older people as part of clinical practice, highlighting the need for ongoing work to achieve further improvement.

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Proportion of participants meeting falls prevention guidelines in an evidence-based community-based exercise program - Aging Clinical and Experimental Research

Background Although exercise is strongly recommended to prevent falls in older adults (exercise that challenges balance, performed three hours per week on an ongoing basis), few community-based programs meet these recommendations. Aims Assess the proportion of participants meeting fall prevention exercise recommendations in a community-based program and explore how adherence varies by individual characteristics and participation mode (in-person, tele-exercise, or hybrid). Methods A cross-sectional analysis of Zoomers in Balance participants who completed an online questionnaire about their demographic data, mode of participation, and their perceived balance intensity in a 12-week series using the Balance Intensity Scale (1-no effort at all to 5-maximal effort). Weekly attendance was self-reported after each 12-week series, and ongoing participation was assessed using registration data over one year. Results The average perceived balance intensity was 3.2 ± 0.7 (range 1–5), the average attendance was 1.3 ± 0.6 h/week (range 0.2–4.2), and participants attended an average of 3.4 ± 0.6 series/year (range 2–4). None of the participants met all three guidelines. The most fulfilled recommendation was ongoing participation (43%), which was greater in the hybrid (B = 2.68; p < 0.001) and tele-exercise (B = 1.28; p < 0.001) groups compared with the in-person mode. In addition, the mode of participation was associated with meeting one or more guidelines (χ2 = 23.05; p < 0.001), without any significant difference between modes. Discussion Offering hybrid participation options could lead to greater adherence to evidence-based guidelines, thereby reducing the risk of falls. Conclusion The proportion of participants meeting fall prevention guidelines in a community-based program is low, with a trend indicating that hybrid options are more effective.

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