Job alert! I'm recruiting a new post-doc to work on mechanisms of co-translational quality control in the ER. Looking for expertise in ribosome biology and yeast genetics/cell biology. Please reach out to me with any questions. www.dundee.ac.uk/work-for-us/...

Postdoctoral Research Assistant - UOD2336

Closing date: Thursday 27 August 2026, 23:59

dundee.ac.uk

Finally out - our work on high throughput design and characterization of disordered protein sequences 🪱🪱🪱. A long time collaboration with BFFs @alexholehouse.bsky.social and @remenecker.bsky.social, with experimental work led by @trevorbrandt.bsky.social and @karaehunt.bsky.social.

Rational design of disordered proteins for sequence–function investigation - Nature

GOOSE enables the design and testing of thousands of disordered protein region sequences to reveal distinct sequence-to-function relationships.

nature.com

Everything you wanted to know about the protein chemistry behind how amino-acid changes affect the cellular abundance of proteins from @tkschulze.bsky.social Effects of residue substitutions on the cellular abundance of proteins doi.org/10.7554/eLif...

Are you analysing hydrophobicity in disordered proteins and still using the Kyte & Doolittle scale? Maybe instead consider the "stickiness-scale" that Fan & Giulio derived using SAXS data for >100 IDPs doi.org/10.1021/acs....

Partitioning of Rubisco activase into the pyrenoidal Rubisco condensate is mediated by a functional protein-protein interaction "https://doi.org/10.1038/s41467-026-70724-5" www.nature.com/articles/s41...

Partitioning of Rubisco activase into the pyrenoidal Rubisco condensate is mediated by a functional protein-protein interaction - Nature Communications

Algal photosynthesis relies on a biomolecular condensate known as the pyrenoid, which sequesters the cell’s Rubisco. The pyrenoid constituent Rubisco activase partitions to the condensate via an eleme...

nature.com

😭 openai.com/index/introd...

Introducing GPT-Rosalind for life sciences research

OpenAI introduces GPT-Rosalind, a frontier reasoning model built to accelerate drug discovery, genomics analysis, protein reasoning, and scientific research workflows.

openai.com

This is (I think) a Greater Blue-Eared Starling (Lamprotornis chalybaeus) & the amazing chrome job is their super-power. They've evolved to manipulate light in VERY specific ways, attracting mates, intimidating rivals. Let's look at the nanostructures that bring this bling into being.

If you consider 'hiring’ AI instead of a graduate student, you're saying the quiet part out loud: PhDs are viewed as a PI's labor force not academics studying for an advanced degree... www.science.org/content/arti...

We are hiring a postdoc in computational biophysics and machine learning studies of intrinsically disordered proteins We aim to study the function of IDPs by combining CG MD, ML and bioinformatics in collaboration with @tanjamittag.bsky.social & @rhp-lab.bsky.social tinyurl.com/REWIRE-PD

This is kinda bonkers. In addition, 20 amino acids were found on Ryugu, along with uracil and vitamin B3. These have been found in other instances, but since the samples from Ryugu were collected directly from the asteroid and delivered in sealed capsules, contamination on Earth could be ruled out.

Nature Astronomy@natastron.nature.com · 5mo ago

Samples returned from the asteroid Ryugu contain all five canonical nucleobases (A, G, C, T, U). Their presence in Ryugu and Bennu supports the hypothesis that carbonaceous asteroids contributed to the prebiotic chemical inventory of early Earth. http://dlvr.it/TRWtVp ☄️

When you still haven't solved the orientation bias of your protein sample #CryoEM

With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR www.nature.com/naturecareer...

Papers are like buses... You wait for ages, then two come along at once. Huge congrats to @bornanovak.bsky.social and @jefflotthammer.bsky.social for pushing and driving every aspect of this work, preprinted ~1 year ago to the day (Friday before BPS), now published! www.nature.com/articles/s41...

Accurate predictions of disordered protein ensembles with STARLING - Nature

The deep learning model STARLING can generate accurate ensembles of intrinsically disordered regions of proteins using only protein sequence as input.

nature.com

Borna Novak@bornanovak.bsky.social · last yr.

Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models). www.biorxiv.org/content/10.1...

Structural basis of caveolin-driven membrane bending https://www.biorxiv.org/content/10.64898/2026.02.05.703862v1

As Fran was nice enough to highlight this, I thought I'd put up a brief thread. 3 in 10 proteins that our cells make are either embedded in membranes (ion channels, adhesion molecules, etc.) or secreted (insulin, antibodies). They move through the secretory pathway. 1/

Fran Bottanelli@franbottanelli.bsky.social · 6mo ago

Exciting preprint from the @merz.bsky.social lab proposing how fidelity of membrane fusion is achieved #membranes #trafficking

Exciting opportunity for a #postdoc to join @suyangzhang.bsky.social’s group in the LMB Structural Studies Division to investigate co-transcriptional splicing using cryo-EM and biochemistry. Read more: www.nature.com/naturecareer... Apply by 11 FEB #PostdocJobs #ScienceJobs

Why do mated songbirds sing beautifully coordinated duets? My Ph.D. work showed that duets are cooperative signals that pairs use to defend their shared territory. This visual summary is based on Logue & Gammon 2004 Animal Behaviour 68: 521-531 and Logue 2005 Cognition, Brain, Behavior 9:497-510.

Physicists' perspective on the future direction of condensates in Cell Biology. arxiv.org/abs/2601.03677

Roadmap for Condensates in Cell Biology

Biomolecular condensates govern essential cellular processes yet elude description by traditional equilibrium models. This roadmap, distilled from structured discussions at a workshop and reflecting t...

arxiv.org

Really don’t understand why loads of people are advocating delegation of paper reading and reference searching to AI, and even paper-writing using AI. It’s like volunteering to be left out of the discovery process and intellectual works, happily living as a slave to the “transformers”.

Experimental structures provide valuable hypotheses and accelerate but do not replace evolutionary and statistical analyses of protein sequences

Mathieu M.J.E. Rebeaud@chercheurjuteux.com · 8mo ago

AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination www.nature.com/articles/s41...

Very exciting project! Trafficking, IDRs, and structural biology!

Liz Miller@lizmillercu.bsky.social · 8mo ago

My excellent collaborator, Giulia Zanetti, is advertising for a post-doc to work on our shared MRC grant. Please consider applying to this great lab with a supportive mentor to do some exciting structural biology. www.ucl.ac.uk/work-at-ucl/...

Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have. mrc.tal.net/vx/mobile-0/...

Our review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics With @dariagusew.bsky.social & Carl G. Henning Hansen doi.org/10.1016/j.sb...

I found a tiny octopus on the tide pool🐙✨️ Small as it is, it’s every bit an octopus ... and absolutely adorable!! It even shoots ink🫧 ͛.*

I agree. I think protein folding is evidence that one can form specific structures that are thermodynamically driven by non-specific, dynamic interactions, with additional contributions to specificity from h-bonds etc (that probably contribute less to the "driving" force).

The structure of most folded proteins are stabilised by the hydrophobic effect which in some sense is quite fuzzy. And the hydrophobic cores of proteins can be quite dynamic.

Now published in @cp-cellsystems.bsky.social - we look at the chemical features that make proteins tolerant to dehydration, and the functions these proteins fill. 🏜️🚱 tinyurl.com/bsfy56yt

Protein surface chemistry encodes an adaptive tolerance to desiccation

Desiccated cells lose over 85% of their water content and experience widespread biomolecular dysfunction. Romero-Pérez et al. show that the yeast proteome contains a subset of proteins that are desicc...

tinyurl.com

yep, this is very concerning. Some have already tried to raise the alarm in 2022, and since then, the “quality” of AI-generated images has only improved... www.cell.com/patterns/ful...

Deepfakes: A new threat to image fabrication in scientific publications?

There is an increasing risk of people using advanced artificial intelligence, particularly the generative adversarial network (GAN), for scientific image manipulation for the purpose of publications. ...

cell.com

Pedro Beltrao@pedrobeltrao.bsky.social · 9mo ago

Finally the scary example. The image of a western blot with a time course experiment, staining a protein of interest, showing the increase of protein over time and a second staining with a control antibody that does not change over time

Language models cannot reliably distinguish belief from knowledge and fact #AI Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation. www.nature.com/articles/s42...

Language models cannot reliably distinguish belief from knowledge and fact - Nature Machine Intelligence

Suzgun et al. find that current large language models cannot reliably distinguish between belief, knowledge and fact, raising concerns for their use in healthcare, law and journalism, where such disti...

nature.com