Mirko Pegoraro PhD

@3volution.bsky.social

Lecturer in Epigenetics at LJMU. Focused on understanding Evolution at multiple levels. I am interested in Genetics, Epigenetics and Molecular Biology. 🐝🪰🦟🐜🦠🧬🌈he/him Web: https://shorturl.at/WF8o3 YouTube: https://www.youtube.com/@EEL-2026

🐟🚨 New paper! 🚨🐟 Where do behavioral differences come from? Early life environment clearly matters... ...or not? Early environment affected behavior, but NOT how different individuals became from each other. Those differences were seeded before birth through factors OTHER than genetic variation 🤯

Born This Way: Individuality Is Seeded Before Birth and Robust to Ecological Stress

We reared and recorded behaviours of clonal Amazon mollies in standardized environments, with and without predation stress, from birth through week four of life, to understand how the developmental e...

onlinelibrary.wiley.com

Excited to share this work from @darbly.bsky.social's lab and my lab with @davidhildebrand.bsky.social @briandepasquale.bsky.social and many others! It turns out that the sensory neurons that detect CO2 in Aedes aegypti mosquitoes have lots of recurrent connections! 🦟👃🌟

PLOS Biology@plosbiology.org · 6d ago

CO2 is an important cue used by #mosquitoes when searching for a human blood meal. @darbly.bsky.social @megyounger.bsky.social &co show that the wiring of #neurons that sense CO2 differs from that in #Drosophila, allowing robust detection of this key host cue @plosbiology.org 🧪 plos.io/4cFCPpV

Feedforward connectivity of maxillary palp glomeruli. Top left: Schematic with feedforward OSN-to-PN connections highlighted. Top right: Dendrograms (flattened 2D representations of the 3D dendritic arbor preserving distance information) of uPNs and their incoming feedforward synapses from OSNs. * denotes branch leading to soma, and arrow denotes branch leading to the inner antennocerebral tract (iACT). (top) uPN cable length, glomerular volume, and cable density. Scale bar 100 µm. Bottom left: Coronal view of uPN reconstructions. Scale bar 25 µm. Bottom right: Axograms (flattened 2D representations of the 3D axonal arbor preserving distance information) of representative OSNs with their feedforward synapses to uPNs shown as colored dots. Scale bar 25 µm.

Night eyes 😎 Finally got proper pictures of this amazing phenomenon! Mantises change their eye color (and light sensitivity) at night by transporting pigments from the surface of each compound eye unit toward the deeper eye region. Same female Tenodera sinensis, two different times. #bugsky

A female Tenodera sinensis mantis with dark black eyes against a light background, seen from very close up.A female Tenodera sinensis mantis with green/brown eyes against a light background, seen from very close up to show the details of her face. The pseudopupil is clearly visible on her left eye, facing the camera.

Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22

Weidinger Lab "find that mTORC2 regulates macrophage recruitment to the wound, while mTORC1 is required for wound debris clearance by macrophages... It also appears to directly regulate cardiomyocyte dedifferentiation & proliferation, making mTOR signaling a central hub for regenerative responses."

bioRxivpreprint@biorxivpreprint.bsky.social · 2mo ago

A tight balance of anabolic mTORC1 signaling and catabolic autophagic activity regulates zebrafish heart regeneration https://www.biorxiv.org/content/10.64898/2026.07.23.740244v1

SAMA ET AL: why can't we make a profit with this revolutionary technology ME: your operating cost scales super-linearly with the value it delivers to users SAMA ET AL: better tell the government we have invented the angels from evangelion or something