Do not miss the opportunity to join a great community and catch up on the latest developments in Cancer Metabolism. Terrific lineup + many many slots for selected speakers. Sponsored Travel Grants available. REGISTRATIONS ARE OPEN.
Alessandro Carrer
@acarrer.bsky.social
PI at VIMM and Univ of Padova. Scientist interested in how nutrients dictate fate decisions. Husband and dad(x2).
Now in Cancer Discovery @aacrjournals.bsky.social: Senescent CAFs Drive Early-Stage Lymph Node Metastasis in PDAC via Lactate-mediated Metabolic-Epigenetic Rewiring - by Tianxing Zhou, Jingrui Yan, Jun Yu, Yukuan Feng, Rui Liu, Yongjie Xie, Bin Wang, Jihui Hao, et al. doi.org/10.1158/2159...
Online Now: Do metabolic fluxes change with age? #trends #endocrinology #metabolism
Do metabolic fluxes change with age?
Metabolomes change with age. Yet, fluxomics points to a contradiction: Jankowski et al. in Cell Metabolism report shifts in metabolite concentrations in aged mice, alongside largely preserved metabolite fluxes, evoking important questions on the nature of age-related metabolic disturbances. We discuss how this might recalibrate our understanding of aging metabolism.
dlvr.it
#WeekendRead! #ImmunometabolismPower! #EveryCellIsAnImmuneCell! Ji, Zhang, Lu, Liu &co show @nature.com that infection, irradiation, or lupus #SLE induce a mevalonate intermediates that drives IL6 & CCL20 by #keratinocytes via NFAT to potentate antibody production!
A metabolic alarmin from keratinocytes potentiates systemic humoral immunity - Nature
Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.
nature.com
Registrations for ISCaM 2026 Meeting are finally open!! Join us in Padua (IT) on September 21-23 for science, networking, fun!! Low registration fees, plenty of slots for selected abstracts, travel grants, splendid location, social activities on top of a stellar lineup of speakers!
New paper out in Nature Communications: www.nature.com/articles/s41... We found >250 metabolic enzymes on chromatin. Only ~20 had been reported before. This means hundreds of metabolic enzymes may have unexplored nuclear roles.
Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues - Nature Communications
Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non...
nature.com
Now online in Cancer Discovery @aacrjournals.bsky.social: Targeting the Lipid Metabolism Proteins FASN and GPAM in Alveolar Type II Cells Decreases Lung Metastasis - by Xiao-Zheng Liu, Mariia Yuneva, Sarah-Maria Fendt, and colleagues doi.org/10.1158/2159... @crick.ac.uk
@cp-cell.bsky.social is on 🔥 with #immunemetabolism! Zheng &co show that excessive glycolysis-driven pyrivate cause pyruvylation of STAT1 preventing #interferon signaling 👉 doi.org/10.1016/j.ce... & Finley &co show that ACO2 clears citrate preventing integrated stress response & kidney degeneration👇
Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...
cell.com
What to know more? Join ISCaM2026!!! iscam2026.azuleon.org
ISCaM 2026 :: Welcome
The website of the 13th ISCaM Annual Meeting :: ISCaM 2026
iscam2026.azuleon.org
Christian Frezza@frezzalab.bsky.social · 8mo agoFunctional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction: Molecular Cell www.cell.com/molecular-ce...
Interested in nutrient sensing or the relationship between nutrient availability and cancer? Look no further than ISCaM2026 Registrations open March 2nd
Interested in nutrient sensing or the relationship between nutrient availability and cancer? Look no further than ISCaM2026 Registrations open March 2nd
Dear metabolism lovers, friends… have a look at this year ISCaM meeting that will be hosted in my beautiful Padua. It features a terrific lineup of speakers, plenty of slots for selected talks, several travel grants #ISCaM2026
Today the Italian Pancreatic Cancer Community will host @clausjorgensen.bsky.social for an exciting webinar on TME heterogeneity. Free to join!!!
Excited to announce that registration is officially open for #METPHYS2026! All meeting details can be found here: www.sablesys.com/metphys-the-...
Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc @kimyumi0201.bsky.social: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. 🧵
On this date in 1751, what would eventually become the University of Pennsylvania opened its doors in a building on Fourth Street for the first time. This marked an early moment in a history that now celebrates its 275th anniversary. Read more about Penn’s first campus: https://bit.ly/4gIpLA8
Mouse pancreas epithelial cells with mutant RAS – have prominent nucleoli that sometimes arrange to make little smiley faces 📹 @zeinabrekad.bsky.social @oxfordbiochemistry.bsky.social. At the Dept's imaging facility Micron with @leicamicrosystems.bsky.social THUNDER ➡️ bpod.org.uk/archive/2025...
1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.
link.springer.com/article/10.1... The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells
The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells - The EMBO Journal
Oxidative stress is a major driver of cardiovascular disease; however, the fast changes in cellular metabolism caused by short-lived reactive oxygen species (ROS) remain ill-defined. Here, we characte...
link.springer.com
Anybody got an example of substrate channeling where an isotopic label in a specific product is more enriched than the tracer? I know this is theoretically possible with compartmentalized pools but I am drawing a big old blank on relevant literature?
There is still time for @biochemsoc.bsky.social members to apply for funding for @febsjuniorsection.bsky.social Young Scientist's Forum happening in the Nertherlands in July 2026. Attendance will be supported through funds to support registration, travel and accommodation. Deadline is 10th December
YSF Applications | The 50th FEBS Congress
Apply for the Young Scientists’ Forum at the 50th FEBS Congress. Learn about eligibility, application steps, deadlines, and opportunities for early-career researchers in 2026.
febscongress.org
FEBS Junior Section@febsjuniorsection.bsky.social · 11mo ago🔬 Apply to the FEBS Young Scientists' Forum 2026! 🔬 🗓️✍️ Applications open this week on the 1st of November (deadline 10 December). 🗓️✍️ For more information: febscongress.org/ysf-welcome/
Excited to share our new manuscript on the reprogramming of cholesterol trafficking and sensing in pancreatitis. www.sciencedirect.com/science/arti...
Reprogramming of cholesterol sensing in epithelial cells supports pancreatic inflammation
Pancreatitis is a common cause of hospitalization that necessitates attentive clinical management. Affected individuals are at risk for pancreatic can…
sciencedirect.com
Excited for the opportunity to study how fructose-rich diets promote #pancreaticCancer risk
World Cancer Research Fund@wcrf.org · 11mo ago£5m funding 19 cancer research projects across 9 countries, inc. 🦗 Cricket powder preventing bowel cancer 🧠 Online therapy for brain tumour patients ♳ Microplastics & cancer risk 🇲🇼🇧🇫 Evidence gaps filled in Burkina Faso & Malawi 🍔UPFs in childhood & future cancer risk www.wcrf.org/about-us/new...
Today is #WorldPancreaticCancerDay 💜 #Pancreaticcancer is projected to become the second leading cause of cancer-related deaths in Western societies by 2030. A stark reminder of why our work matters. Today, our thoughts are with all patients and families affected by this devastating disease. 💜 #WPCD
It’s World Pancreatic Cancer Day also for the Carrer lab
www.nature.com/articles/s42... Congrats @jourdainlab.bsky.social & team!!
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
nature.com
Online Now: Single-cell imaging of liver metabolic dynamics using fluorescent biosensors #trends #endocrinology #metabolism
Single-cell imaging of liver metabolic dynamics using fluorescent biosensors
Traditional metabolic studies rely on bulk tissue analyses, masking the cellular heterogeneity that underlies disease progression. Genetically encoded fluorescent biosensors now enable real-time, single-cell imaging of dynamic metabolic processes in the liver. These tools provide insights into the metabolic reprogramming in conditions such as chronic obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and hepatocellular carcinoma (HCC). By tracking specific metabolites involved in glycolysis, lipid oxidation, and the tricarboxylic acid (TCA) cycle, biosensors can reveal how these pathways respond to diverse stimuli. In this review we outline the core principles of fluorescent biosensors, provide specific recommendations for their usage, suggest possible applications in liver metabolism research, and discuss current technical challenges as well as emerging opportunities in this rapidly advancing field.
dlvr.it
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts. www.nature.com/articles/s41...
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications
α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...
nature.com