Anup Parchure
@anupap.bsky.social
Associate Research Scientist at Yale School of Medicine. Interests in phase separation and organization of specialized secretion and insulin signaling. On the job market. Course director in Cell Biology https://www.scienspur.org/
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
Our new publication in Nature Cell Biology 🔬 How cells reseal damaged lysosomes: Ca²⁺ leak → VPS34 makes PI3P on the ER → recruits DFCP1 → clusters VPS13C lipid-transfer bridges at ER–lysosome contacts to patch the membrane. No DFCP1 = failed repair. www.nature.com/articles/s41...
DFCP1-containing ER microdomains mediate lysosomal membrane repair - Nature Cell Biology
Radulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...
nature.com
Our collaborative paper is now out in Matrix Biology! We made TANGO1L KO cells and analyzed them extensively. TANGO1L Is Required for Collagen Secretion in a Type-Dependent Manner and Shapes Collagen Proteostasis in the Endoplasmic Reticulum. doi.org/10.1016/j.ma...
Mishra, @rpadinjat.bsky.social et al. @ncbsbangalore.bsky.social show that CERT protein is required to maintain ER-PM MCS in #Drosophila #photoreceptors, which maintains #phosphoinositide levels at the PM during G-protein–coupled PLC signalling rupress.org/jcb/article/... #Neuroscience
*JobAlert* One more week to apply for a post-doc position in my lab at Dundee to study co-translational protein quality control of secretory and membrane proteins. This is a collaborative project with @kulathu.bsky.social and @zeqiraj.bsky.social www.jobs.ac.uk/job/DSM201/p...
Postdoctoral Research Assistant - UOD2336 at University of Dundee
Discover an exciting academic career path as a Postdoctoral Research Assistant - UOD2336 at jobs.ac.uk. Don't miss out on this job opportunity - apply today!
jobs.ac.uk
Endocytic clathrin coats are surprisingly dynamic: triskelia turn over in seconds. How is the turnover regulated and what is it for? Read Anne-Laure Boinet's preprint with @rouxlab.bsky.social www.biorxiv.org/content/10.6...
Very happy to see this #MechanoGolgi story out (and in full open access, thanks to @upf.edu). Thanks a lot to everyone who contributed and helped make this possible, and, hopefully, more to come! rupress.org/jcb/article/...
Mechanical forces stimulate Golgi export
Bhaskar Naidu and Vera Lillo et al. show that extracellular mechanical forces reciprocally regulate Golgi function. By linking cell adhesion and spreading,
rupress.org
Felix Campelo@felixmendu.bsky.social · last yr.🧵 I've been meaning to write a #Skytorial on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉 www.biorxiv.org/content/10.1...
I made a small VR app for looking at our beta cell reconstructions in 3D. I can also control it from my PC, which makes it nice for outreach events. Pretty happy with how it turned out.
📢 We are looking for a Junior Group Leader to join us at @institutcurie.bsky.social! Having joined the department just over a year ago, I can honestly say that it is an exceptionally stimulating and supportive scientific environment, filled with outstanding colleagues — all in the heart of Paris.
UK-based cell biologist? Interested in membrane trafficking? Want to find a conference? Looking for a job (PI, postdoc...)? Do link to www.ukmembranetraffic.com, where @jezcarlton.bsky.social and Chris Stefan (not here?) do sterling work
@mhakala.bsky.social shows that HRS forms bidimensional condensates onto endosomal membranes to flatten clathrin/ESCRT-0, an observation unexplained since the 2000s. Thx to Kukulski lab, @stefvass.bsky.social @colomlab.bsky.social @kaksonen.bsky.social @mishakudryashev.bsky.social rdcu.be/fihKk
Out now in @annualreviews.bsky.social: my review on the origins of eukaryotic membrane traffic! I propose that archaea-derived proteins supported a primordial system of tubules to ferry cargo between compartments. Modern coated vesicles may have been a later innovation. doi.org/10.1146/annu...
A Tubules-First Model for the Origin of Eukaryotic Membrane Traffic
The discovery of membrane trafficking proteins in Asgard archaea—the closest archaeal relatives of eukaryotes—reveals the deep evolutionary roots of the eukaryotic endomembrane system. This review syn...
doi.org
It was fun writing this with David @dgershlick.bsky.social! Check it our if you want to hear our view on small #GTPases networks in endosomal trafficking :) part of the themed issue on Membrane trafficking edited by @fromme-lab.bsky.social and Philippe Chavrier www.sciencedirect.com/science/arti...
Dynamic GTPase networks reshaping endosomal organelle identities
Endosomal GTPases, while often used as markers for specific endosomal organelles, functionalize the surface of endosomal compartments into biochemical…
sciencedirect.com
RNA-specific local translation is patterned by condensates for multinucleate cell growth www.nature.com/articles/s41...
RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology
Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...
nature.com
You are finishing your PhD and looking to continue in science? The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro.... Thanks for reposting!
Contact/Job - Department of Molecular and Cellular Biology - UNIGE
mocel.unige.ch
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET
learned to write this way from my PhD advisor. Some journals however have a limit on the word count.
Thiago Carvalho@cyrilpedia.bsky.social · 9mo agoThe Platonic Ideal "The key point with figure legends is that it should be possible for a reader to ignore the entire manuscript! With only the figures & fig legends to go on, they should be able to understand what you've done & (roughly)what you’re trying to demonstrate" @tirscienceblog.bsky.social
Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
bioRxivpreprint@biorxivpreprint.bsky.social · 10mo agoOrganelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
Come to be our colleague! Center of Paris, excellent facilities, research spanning the whole range of basic and biomedical life science topics, enthusiastic and collaborative colleagues, crème brûlée every Friday... What else could one want?
Institut Pasteur | 130 years of biomedical research@pasteur.fr · 10mo ago🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research
Join us tomorrow for the inaugural Metabolism in Development & Physiology online seminar! We have an exciting line up of talks planned for the coming months from leaders in the field and concurrent trainee talks. Submit your abstracts soon for 2026! 🕓 Every 2nd Thursday | 16:00 CET
Metabolism in Development and Physiology, Virtual Seminar Series@devmetphys.bsky.social · 11mo agoWe’re excited for our very first “Metabolism in Development & Physiology” seminar next week! 🗓 13 Nov 2025, 16:00 CET 🎙 Alexander Aulehla (EMBL Heidelberg) 🎙 Christopher Bell (Uni of Oxford) Register here to join the the talks: forms.gle/Y8QzucogKKrZ...
The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
crick.ac.uk
A new set of very cool results in support of cisternal maturation of the Golgi apparatus. It is very intriguing that the debate is ongoing with new approaches.
MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 12mo agoProviding order amongst constant traffic: #LMBResearch from Sean Munro (@cellbiol-mrclmb.bsky.social) with John Briggs (@mpibiochem.bsky.social) reveals how GOLPH3 allows COPI vesicles to distinguish between Golgi residents & ER-bound proteins. Read more: www2.mrc-lmb.cam.ac.uk/protein-sort...
Be our new colleague! 🎉 The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor. 👉 More details here: lnkd.in/e8Z9eAm4 👉 Our department: mocel.unige.ch Please feel free to share this opportunity with your network.
🧵 I've been meaning to write a #Skytorial on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉 www.biorxiv.org/content/10.1...
Mechanical forces stimulate Golgi export
Human cells face a wide range of external mechanical stimuli that vary with cell type, state, and pathological conditions. The rapidly growing field of mechanobiology investigates how cells sense and ...
biorxiv.org
We're recruiting junior team leaders @mrc-lms.bsky.social This time we're looking for those working in human metabolic disease. It's a great place to start your lab. Fantastic colleagues, exciting science, world class facilities. Join us! lms.mrc.ac.uk/work/vacanci...
Programme Leader Track - MRC Laboratory of Medical Sciences
We are recruiting Programme Leader Track positions focusing on 1) Metabolic Physiology using murine and/or human in vivo models and 2) Immunometabolism.
lms.mrc.ac.uk
Role of clathrin adaptor complex AP3 in secretion of dense core vesicles from the Sahu lab, NBRC. Badal from my lab has added an experiment testing the role of AP3 in secretion of neuropeptides in C. elegans.
bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · last yr.AP-3 complex sorts preferential cargo to govern dense core vesicle function in neuroendocrine cells https://www.biorxiv.org/content/10.1101/2025.06.27.661901v1
An important piece of my postdoctoral work now out. My first entry into the early secretory pathway regulation had many interesting surprises. Thanks for the collaboration @ishier.bsky.social. The deflects in collagen secretion really elevated the paper.
Ishier Raote@ishier.bsky.social · last yr.Is the ERGIC a stable organelle? How are its identity and diverse roles maintained? @anupap.bsky.social (Bogan lab, Yale) shows TUG maintains ERGIC integrity, shaping cargo flux and functions like collagen secretion and autophagy—a cargo-selective brake via ERGIC organisation. rdcu.be/euig6
Farewell America. I am leaving with many new deep connections and bonds. I couldn't be more content and thrilled about my postdoctoral work especially with positive news about a manuscript in the last few days. Hopefully a new chapter in my life will begin soon. Now back to applications 😀.
ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion
ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion
Sue et al. show that ER stress impairs insulin secretion by misplacement of permissive proteins from the plasma membrane. This results from defects in the retromer and the constitutive secretory pathway. Thus, in type 2 diabetes, ER stress mediates β cell dysfunction, not just loss of β cell mass.
dlvr.it
