Planar cell polarity-directed cell crawling drives polarized epithelial morphogenesis: Current Biology www.cell.com/current-biol...

Planar cell polarity-directed cell crawling drives polarized epithelial morphogenesis

Sharan et al. investigate how planar cell polarity (PCP) directs counter-rotational cell flows during hair placode morphogenesis by coordinating cell crawling at the basal surface. 3D imaging and comp...

cell.com

Big paper from @hejnol.bsky.social lab. Title says it all. Congrats, Stanislav Kremnyov and the team. www.nature.com/articles/s41...

A blastoporal organizer in a ctenophore - Nature

Experiments using the comb jelly Mnemiopsis leidyi and the sea anemone Nematostella vectensis reveal that the emergence of a core signalling pathway may have been a key innovation enabling the transit...

nature.com

Our work on Trichoplax locomotion and mechanosensing capabilities is out now in @currentbiology.bsky.social. Congrats Marvin Leria & all co-authors! authors.elsevier.com/c/1n8Ig3QW8S...

Really happy to share my PhD story about the regulation of developmental speed in the Drosophila eye 🪰😃👀, which is now published @embojournal.org: link.springer.com/article/10.1... Grateful to everyone who make this possible, particularly F. Schweisguth @pasteur.fr @devstempasteur.bsky.social

The vertebrate yolk sac: evolutionary origins & current advances in #invitromodels Blagrove & co examine the evolution of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, & explore how in vitro models are uncovering its biology. doi.org/10.1242/dev....

We are happy to share our new bioRxiv pre-print on A-P axis patterning. A great collaboration with Felix Zhou (UT Southwestern) & the Yeomans group (Physics, Oxford) www.biorxiv.org/content/10.6...

New paper out in @cp-cellstemcell.bsky.social. We uncover unexpected complexity in how metabolism changes when the embryo implants or when stem cells exit naive pluripotency, revealing a central role for dynamic TCA cycle rewiring in cell fate decisions. www.cell.com/cell-stem-ce...

TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency

Using carbon tracing and functional experiments, Kafkia, Pladevall-Morera, et al. show that TCA cycle rewiring underlies mouse embryo implantation and the exit from naive pluripotency. In this context...

cell.com

Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.

I’m pleased to share our latest preprint (my first as 1st-author) from Jérôme Gros’ group (@jeromegros.bsky.social), now on bioRxiv. It reports actin and myosin dynamics during epithelial remodeling in avian gastrulation. (doi: doi.org/10.64898/202...)

Actin and myosin dynamics during epithelial remodeling in avian gastrulation

Epithelial remodeling is powered by contractile forces exerted by the actomyosin cytoskeleton. In invertebrates, pulsatile contractile flows of the medio-apical actomyosin cortex have been shown to be...

doi.org

Wnt and Nodal asymmetries stratify mouse laterality phenotypes in the absence of node flow https://www.biorxiv.org/content/10.64898/2025.12.21.695689v1

#RésultatScientifique 🔎 | Comment les filaments d'actine s'organisent à l'intérieur des cellules et des tissus vivants 🔬 @institutfresnel.bsky.social 🤝 @univ-amu.fr @centralemed.bsky.social @cnrs.fr 📍 @cnrs-dr12.bsky.social

Comment les filaments d'actine s'organisent à l'intérieur des cellules et des tissus vivants

En utilisant la microscopie de fluorescence résolue en polarisation, les biologistes et physiciens de l'Institut Fresnel, associés à une équipe internat

insis.cnrs.fr

Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh 🧵 www.sciencedirect.com/science/arti...

Investigating morphogen and patterning dynamics with optogenetic control of morphogen production

Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…

sciencedirect.com

Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6

Very happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics

Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

nature.com

If you’ve been following this account closely, you might already know methods to probe mechanics in vitro, but what about in live embryos? I’m @amichaut.bsky.social, and I’m going to share a few great papers on this aspect of #EpithelialMechanics.

Here is what I have been up to in the lab of @stephangrill.bsky.social together with @neipel.bsky.social and many others. Intrigued by avian left right symmetry breaking we found that a tissue-scale active torque drives chiral flow and requires mechanical coupling to the underlying tissue.

Jonas Neipel@neipel.bsky.social · last yr.

(1/10) I am excited to finally share our work on avian left/right symmetry breaking with you. We reveal a tissue-scale active torque dipole generated at the Hensen’s node, thanks to crazy experiments by Julia @juliapfanzelter.bsky.social and some analysis by me. doi.org/10.1101/2025...

🏳️‍🌈Our editor @slefkopoulos.bsky.social discussed with @jzylicz.bsky.social about the importance of celebrating Pride, representation in science, and more! Happy Pride! Read here: rdcu.be/ewfba bit.ly/3Uc72TO

Coming out is not a one-time event - Nature Cell Biology

June is the month celebrating Pride in the USA and other countries around the world to honour the Stonewall Uprising of 1969, as well as all progress and current strives claiming equal justice for mem...

bit.ly

Many thanks to Ruoheng Li and @prelights.bsky.social for featuring our preprint!

preLights@prelights.bsky.social · last yr.

Seeing and (not) believing! On the role of hypoblast in primitive streak induction. In her second #preLight, Ruoheng Li covers the #preprint by @aurelienvilledieu.bsky.social and the @jeromegros.bsky.social's research team.

🚨 A very interesting conference on gastrulation coming up soon 🚨 Don't miss the chance to interact with these renowned speakers! Early bird deadline: July 15th

Jérôme Gros@jeromegros.bsky.social · last yr.

Registration is now open! Gastrulation Reloaded: Developing, engineering & evolving the body plan 📅 October 14–17, 2025 📍 Paris, France 🗓️ Abstract & early bird deadline: July 15, 2025 www.gastrulation-reloaded.conferences-pasteur.org/home Exceptional lineup of speakers & many selected talks

🧵Just out ! We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration. Here’s the story👇 authors.elsevier.com/c/1lM285Sx5g... Work done in @frelab.bsky.social at ‪ ‪ @institutcurie.bsky.social

🥳 Thrilled to share our lab's first preprint, led by our talented postdoc Justine Creff! 👩🏻‍🔬 We tackled a fundamental question: how the epithelium withstands mechanical stress at the interface of cells with distinct geometries and mechanics, such as enterocytes (E) and goblet cells (G) (1/9)

The effector caspases drive cell death, but their activation can often be survived, so how do cells make this decision? Our new preprint from @levayerr.bsky.social shows that instantaneous caspase activity is important, but past activation has a key role to play! www.biorxiv.org/content/10.1...

🚨New preprint Glad to share my postdoc work on the role of the hypoblast in primitive streak induction! Discover how live imaging observations led us to revisit the molecular mechanisms governing embryonic axis induction Thanks to @jeromegros.bsky.social and all co-authors! doi.org/10.1101/2025...

Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction

In birds and mammals, the formation of the primitive streak, the hallmark of the primary axis and site of gastrulation, is thought to occur when an anterior displacement of the hypoblast (visceral end...

doi.org

🚨📣 New preprint alert! Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos! A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social 📄 www.biorxiv.org/content/10.1... #devbio #mechanics

Direct measurements of active forces and material properties unveil the active mechanics of early embryogenesis

Despite progress in probing tissue mechanics, direct long-term measurements in live embryonic epithelia are lacking. This limits our understanding of amniote embryonic morphogenesis, which takes place...

biorxiv.org

ICYMI: Commentary on "mechanism" in dev bio Ozpolat et al argue for diverse approaches to mechanism - from molecular to systems level journals.biologists.com/dev/article/...

A case for broadening our view of mechanism in developmental biology

ABSTRACT. Developmental biologists can perform studies that describe a phenomenon (descriptive work) and/or explain how the phenomenon works (mechanistic work). There is a prevalent perception that mo...

journals.biologists.com

Announcing this upcoming conference: GASTRULATION RELOADED: Developing, engineering, and evolving the body plan Join us as we explore the latest research on gastrulation and axis formation/elongation, featuring common, exotic, and synthetic embryos! 📅 14–17 October 2025 📍 Paris, France