"Ribosome Heterogeneity Revealed by Complex-Up Native Mass Spectrometry and Top-Down Proteomics" has made it onto the cover of this week's #JACS! Explore the science behind the artwork: buff.ly/zj0j5nx

UMich Biophysics has an open search for a new faculty member. Application materials are due 5/15. Search is open rank (despite the title in the link). Would love to bring more structural biology colleagues to Biophysics. #NMR careers.umich.edu/job_detail/2...

Lund University, Sweden, is recruiting an Assistant Professor in Biophysical Chemistry with a focus on NMR Spectroscopy lu.varbi.com/en/what:job/... #NMRjobs #NMRchat #NMR #chemsky 🧲

Assistant Professor in Biophysical Chemistry with a focus on NMR Spectroscopy

The Chemistry Department at Lund University, Faculty of Engineering invites applications for a position as Assistant Professor in Biophysical Chemistry with a focus on NMR Spectroscopy. Description of

lu.varbi.com

We would love feedback on a new NCBI-BLAST service we are launching today: sky-blast.com Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable

The AAUP wholly condemns this punitive weaponization of federal grant funding. This attempt to discipline & control a university campus is a transparent hallmark of authoritarian rule & harshly violates the central mission of education to serve the public good. www.nytimes.com/2025/03/07/n...

White House Cancels $400 Million in Grants and Contracts to Columbia

The Trump administration blamed the university’s failure to protect Jewish students from harassment during protests last year over the war in Gaza.

nytimes.com

For International Women's Day, here are twelve more women from chemistry history, with achievements ranging from developing antifungal medicines to creating milk substitutes for people with lactose intolerance 👩🏽‍🔬👩🏻‍🔬 www.compoundchem.com/2025/03/07/i... #IWD2025 #ChemSky 🧪

Please share: @delauro.house.gov is cochair of the US House Congressional Rapid Response Task Force and Litigation Working Group. They are looking for instances where the impoundment and restriction of NIH/NSF funds is having a negative impact. Submit examples here delauro.house.gov/constituent-...

2025 Federal Financial Assistance Freeze

On Monday, January 27th, 2025, President Trump issued an order to freeze virtually all of approved and legally required federal funding.

delauro.house.gov

RNA xkcd.com/3056

Science IRL decisions went out today! We were able to fund 13 of the 77 proposals that were submitted. They are communicating science in stage productions, boxes at bus stations, interactive frog statues, musical performances, farmers market tables, backs of cars, knitting clubs, and much more.

If you have an undergrad that will graduate this year but who needs a little more research experience before their next step, encourage them to apply to the UConn RAMP program. genome-postbac.biology.clas.uconn.edu. The application deadline for the 2025 cohort is February 21st. 🧪 1/2

Home | Research and Mentoring for Postbaccalaureates

Welcome to the UConn RaMP on Genomic NoveltyUConn RaMP is the yearlong Research Training Program for recent graduates with a primary focus on first generati ...

genome-postbac.biology.clas.uconn.edu

Today is the International Day of Women and Girls in Science 👩‍🔬🧑🏽‍🔬 The Women in Chemistry category on the Ci site has a range of graphics on women in chemistry, both historical and present-day! www.compoundchem.com/category/wom... #ChemSky 🧪 #WomenInScience

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Special Bluetorial: The benefits of different life experiences The scientific community has folks with a very wide range of life experiences. We have a lot to learn from one another.

a cartoon says hey everybody an old man 's talking while bart simpson looks on

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

media.tenor.com

Preprint, In situ light-driven pH modulation for NMR studies, Aarav Barde, Ruixian Han, Martin A. Olson, Marco Tonelli, Chad M. Rienstra, Katherine Henzler-Wildman, Thirupathi Ravula www.biorxiv.org/content/10.1... #NMRchat #NMR

Let's make a thread of RNA-related conferences in 2025 🧵 (add missing!)

Let me give a concrete example of the importance of applications with high risk-high reward as well as the role of NIH staff in taking risks. Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible). 1/n

Upcoming Magnetic Resonance Events, Workshops and Conferences (pinned) #NMRchat #NMRevents #NMR

Happy #TryptophanWednesday!

Catherine Eichhorn@cdeichhorn.bsky.social · 2y ago

The intervening loop is highly conserved and contains a tryptophan cage, previously reported in the synthetic tryptophan cage (Trp-cage) peptide. To our knowledge, this is the first time a tryptophan cage has been reported in a naturally occurring protein.

📣 Final version of our @elife.bsky.social article is now online! We show how the human tRNA methyltransferase TRMT1 is recognized, cleaved, and inactivated by the SARS-CoV-2 main protease to disrupt host tRNA modification! elifesciences.org/articles/91168 A short bluetorial... 🧵 1/9

Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease

The SARS-CoV-2 main protease specifically cleaves a conserved sequence in the human tRNA modifying enzyme TRMT1, resulting in reduced tRNA binding and the complete loss of TRMT1-mediated tRNA methyltr...

elifesciences.org

PUI chem profs, ACS Omega is doing a call for PUI papers! Also, the OA charges are covered for PUI's that participate in the ACS PUI OA program (there's a list of participating schools, I'll post that list as a comment to this post). axial.acs.org/cross-discip...

Call For Papers: Undergraduate Research as the Stimulus for Scientific Progress in the USA | ACS Publications Chemistry Blog

This Special Issue will highlight the significant research activities at Primarily Undergraduate Institutions (PUIs) in the United States and their unique focus on fostering student engagement in STEM...

axial.acs.org

Happy to share our latest work! Here, we solved the X-ray crystal structure of the hnRNPR RRM1 (our group’s first structure!). We identified an extended RRM (eRRM), where a 45-aa N-terminal extension (Next) motif docks to the RRM: www.biorxiv.org/content/10.1...

Registration for the the joint meeting of Asia Pacific NMR meeting and NMRS India meeting are on going. Register soon to avoid late registration charges. Look forward to seeing you in Pune in June 2025. #NMR #NMRChat tinyurl.com/apnmr-nmrs-2...

APNMR-NMRS-2025

A four-day summit of talks, activities, and interactions. Dear Colleagues, Friends, and NMR Enthusiasts We are pleased to invite you all to the Joint Meeting of the 11th Asia-Pacific NMR and the 30th...

tinyurl.com

I've created a new plugin for #PyMOL (called PyMOLfold) that allows you to fold protein sequences right in the GUI. Simply select your model of choice (e.g., #ESM3, Boltz-1) and paste in your amino acid sequence. github.com/colbyford/Py... #ai #proteinfolding #alphafold

Excited to announce a new collaborative preprint about a structural concept 'local stability compensation'. This states structurally important motifs must be flanked by more stable helices. We observe this effect natural occurring RNAs and experimentally evaluate it. www.biorxiv.org/content/10.1...

I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏 www.nytimes.com/2024/12/09/h...

🌟 Meet the next American Crystallographic Association Early Career Scientist Spotlight: Naba Krishna Das! A grad student, he researches RNA structural biology. Formerly a chemistry teacher with a passion for research, collaboration, and connecting with others. www.amercrystalassn.org/ys-spotlight...

Hi Team #NMRchat #NMR. Happy to see you out here! Let's start spreading the word about the ENC-ISMAR Joint Conference, April 6-10, 2025. Oral Abstract Deadline: January 10 www.enc-conference.org/enc-ismar-2025

I am ***absurdly*** excited to announce the launch of a new funding opportunity through Experiment dot com!!! You have one month to pitch something wonderful in the realm of plant biology/biotech research and education. $10,000 max grant. PLEASE RE-POST + SHARE!!! 1/3 experiment.com/programs/pla...

Plant Biology Exploratory Research Microgrant | Experiment

For Science!

experiment.com

It's great to see the latest RNA puzzles paper has come out. www.nature.com/articles/s41... Its a must-read for those interested in RNA structure prediction!

RNA-Puzzles Round V: blind predictions of 23 RNA structures - Nature Methods

The results of the Fifth RNA-Puzzles contest highlights advances in RNA three-dimensional structure prediction and uncovers new insights into RNA folding and structure.

nature.com

We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered??? www.nature.com/articles/s41...

Stereochemistry in the disorder–order continuum of protein interactions - Nature

Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.

nature.com