Fresh preprint from the lab: CIP2A tetramerization is required for mitotic DNA repair. A fantastic collaboration with @marcelvanvugt.bsky.social. By @laurendehaan.bsky.social, @rebeccaschneeweiss.bsky.social, and colleagues from Groningen, Vienna, Leiden, and Amsterdam 🙌 doi.org/10.64898/202...

Proud to see this preprint from @virginiabusetto.bsky.social out today — she's uncovered how a pseudohelicase-centered complex couples RNA cleavage to poly(UG)ylation. Beautiful mechanistic work from the lab, go check out the thread! 🧵

Virginia Busetto@virginiabusetto.bsky.social · last wk.

Very excited to share our new preprint: “A pseudohelicase-centered complex couples assembly-dependent RNA cleavage to poly(UG)ylation”! 🎉 Want to know more? 🧵👇 www.biorxiv.org/content/10.6...

Great work. It shows again how interesting the evolution of small rna systems is.

René Ketting@reneketting.bsky.social · 2w ago

Happy to share PhD work of @shamithagovind.bsky.social She unraveled how GTSF1, a protein known from the Piwi field, regulates RdRP in nematodes. Thanks also to @psarkies.bsky.social @sebastianfalk.bsky.social Ralf Sommer, Falk Butter, @migueldvalmeida.bsky.social link.springer.com/article/10.1...

👀 Keep cutting-edge RNA research running behind the scenes! The @sebastianfalk.bsky.social lab is looking for a Research Technician/Lab Manager to support research on the molecular machines that process RNA using structural biology, biochemistry, and biophysics ➡️ tinyurl.com/nrjj6bvt

I am thrilled to share our paper out in @cp-cell.bsky.social : "Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways." (1/4) www.cell.com/cell/fulltex...

Systematic discovery of pathogen effector functions across human pathogens and pathways

The eORFeome, a large-scale collection of open reading frames encoding viral proteins and secreted bacterial and parasite effectors, enables functional genomics across diverse pathways and pathogens. ...

cell.com

🔬 Passionate about RNA biology? Join the lab of @sebastianfalk.bsky.social for your Master's project to explore the function of proteins and protein complexes using cutting-edge biochemical, structural, and cell biology approaches ➡️ tinyurl.com/3k7upan4

I’m very happy to be part of our FWF “Emerging Fields” consortium! Together with @gekaragoz.bsky.social, @sebastianfalk.bsky.social and CCRI/CeMM/VetMedUni colleagues Eleni Tomazou, @dseruggia.bsky.social and @floriangrebien.bsky.social, we will study the ribosome code in pediatric cancers.

Max Perutz Labs Vienna@maxperutzlabs.ac.at · 6mo ago

A strong Perutz presence in a new @fwf-at.bsky.social consortium: @elifkaragoz.bsky.social will coordinate the Emerging Fields project 'Translating the Ribosome Code of Pediatric Cancers' 🤝 The team includes @sebastianfalk.bsky.social and @marco.heinlab.org ➡️ tinyurl.com/3d6z3ry5

Die Universität Wien ist an vier von insgesamt sechs neuen Emerging-Fields-Konsortien des @fwf-at.bsky.social beteiligt: Förderungen für die Bereiche #Kognitionsbiologie, #Genregulation, #Nanoplastik und #Mathematik. 🧪👨‍🔬👩‍🔬 Mehr Informationen zu den Projekten hier: ⤵️ www.univie.ac.at/aktuelles/pr...

A strong Perutz presence in a new @fwf-at.bsky.social consortium: @elifkaragoz.bsky.social will coordinate the Emerging Fields project 'Translating the Ribosome Code of Pediatric Cancers' 🤝 The team includes @sebastianfalk.bsky.social and @marco.heinlab.org ➡️ tinyurl.com/3d6z3ry5

We are excited to share our new preprint: iCLIP3 — an improved protocol for transcriptome-wide mapping of protein–RNA interactions at single-nucleotide resolution.

bioRxivpreprint@biorxivpreprint.bsky.social · 7mo ago

iCLIP3: A streamlined, non-radioactive protocol for mapping protein-RNA interactions in cellular transcripts at single-nucleotide resolution https://www.biorxiv.org/content/10.64898/2026.03.01.708747v1

This is a video summarizing our recent paper (www.nature.com/articles/s41...) youtu.be/eNY2CRlYTRo

And the 4th paper in this week contribution from our lab tells about ribosome biogenesis in yeast. A follow-up story from our wonderful collaborators in Graz - the Bergler Lab. Structural work was again done by the amazing @lgrundmann.bsky.social: academic.oup.com/nar/article/...

A comprehensive view on r-protein binding and rRNA domain structuring during early eukaryotic ribosome formation

Abstract. Formation of the eukaryotic ribosomal subunits follows a strict regime to assemble ribosomal proteins (r-protein) with ribosomal RNAs (rRNA) whil

academic.oup.com

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET

GERMAN PRESIDENT STEINMEIER: “.. the United States has broken with the values that it helped to establish .. “.. we have now moved beyond the stage where we can lament the lack of respect for international law or the erosion of the international order; we are far beyond that, I believe.”

Interested in the unexpected? How about a link between piRNAs and maternal histone mRNAs … Great collab with @sebastianfalk.bsky.social, @koenig-lab.bsky.social and Florian Steiner. #piRNA #histone #mRNA #maternal #RNAbiology #RNASky www.biorxiv.org/content/10.6...

Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway. And found a hidden RNA-decay axis from Piwi to the RNA exosome.

bioRxivpreprint@biorxivpreprint.bsky.social · 9mo ago

RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing https://www.biorxiv.org/content/10.64898/2025.12.16.694471v1

RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing https://www.biorxiv.org/content/10.64898/2025.12.16.694471v1

RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing https://www.biorxiv.org/content/10.64898/2025.12.16.694471v1

Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...

Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668

The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a   Tenure Track Professors...

nature.com

📢 New preprint: Experiment-guided AlphaFold3 resolves accurate protein ensembles. doi.org/10.1101/2025... AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇

As 2025 comes to an end, it’s time for me to say good bye to my postdoc home during the past 6 years – the Pauli lab @pauligroup.bsky.social @impvienna.bsky.social

Come discuss recent breakthroughs in RNA biology, from molecules to organisms, at the EMBO | EMBL Symposium 'The complex life of RNA'! 👉 s.embl.org/ees26-12-bl Submit your abstract by 7 July and present your research at #EESRNA 🥼

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

When transposons jump, genomes diverge - even in cultured cells. I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)

Professorship in plant genetics. The Botanical Institute at Kiel University is advertising a W2 professorship. Great opportunity to do plant research in the north of Germany. See: www.berufungen.uni-kiel.de/de/dateien/o...

PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity. But how does piRNA-guided target interaction translate into silencing? PhD student Júlia Portell Montserrat has an intriguing answer www.cell.com/molecular-ce...

I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October. More info: www.imb.de/students-pos...

Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo

🎉 Congrats to @kgaurav.bsky.social, Lukas Stelzl & @reneketting.bsky.social (SFB1551) on their new Biophysical Journal paper! #MUT16 #PhaseSeparation #MutatorFoci #SmallRNA #GeneRegulation #Celegans #ProteinAssembly #RNAResearch #MultiscaleSimulations Great teamwork👏👏👏 www.cell.com/biophysj/ful....

Multi-scale Simulations of MUT-16 Scaffold Protein Phase Separation and Client Recognition

Phase separation of proteins plays a critical role in cellular organisation. How phase separated protein condensates underpin biological function and how condensates achieve specificity remain elusive...

cell.com

Happy to share the latest work on a bacterial protein that inhibits human mRNA decay machinery, in collaboration with @smlea.bsky.social #RNAsky www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications

Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay - Nature Communications

Intracellular pathogens hijack host gene expression to subvert cellular processes. Here, the authors show that Legionella pneumophila’s PieF effector inhibits the human CCR4-NOT deadenylation machiner...

nature.com