Please welcome Dr. Radu Zabet! He graduated at Politehnica University of Bucharest and completed his PhD in Computer Science at Kent. His research focused on the application of genomics, computer science, and physics to study gene regulatory networks. Check more details about Dr. Zabet below🚀

🚨 Excited to share the latest work from my lab “Explainable AI identifies H3K18ac as a new marker of active enhancers” www.biorxiv.org/content/10.6.... Spearheaded by the amazing Khizra Maqsood and Duarte Pólvora-Brandão with contributions from Jareth, Bhavana, Catalin, Roxana, Olivia and Fanny. 1/n

🚨 Excited to share a new manuscript from the lab. Here, we have developed a new method, HiCPotts, to identify significant interactions in 3D chromatin data www.biorxiv.org/content/10.6...; package bioconductor.org/packages/HiC.... Big shoutout to an amazing previous PhD in the lab Godwin. 1/n

🚨 We discovered a new mode of Hox gene regulation in annelids! 🪱 A distal enhancer acts as a "global control region", lifting Hox genes from Polycomb repression. This is reminiscent of Hox gene control in vertebrates, but the two modes likely evolved convergently. www.biorxiv.org/content/10.6...

Checkout the latest paper from @smarino0111.bsky.social on cerebellar organoids as models of medulloblastoma initiation. Happy to have contributed to this story as part of our long term collaboration with Silvia including within the BTR Centre for Excellence @braintumourrsch.bsky.social

Silvia Marino@smarino0111.bsky.social · 3mo ago

Delighted to share our latest work @genesdev.bsky.social on cerebellar #organoids as models of #medulloblastoma initiation. Great work of Tom Willott/James Nicholson 🙏🏻 to collaborators/funders in particular Sara Badodi @raduzabet.bsky.social @braintumourrsch.bsky.social @cruk-si.bsky.social

If you want to read more about our recent work on how gene body methylation buffers noise in gene expression academic.oup.com/nar/article/... , @jamespblloyd.bsky.social has a excellent spotlight in @cp-trendsgenetics.bsky.social.

Gene body methylation buffers noise in gene expression in plants

Abstract. Non-genetic variability in gene expression is an inevitable consequence of the stochastic nature of processes driving transcription and translati

academic.oup.com

James Lloyd 🧬@jamespblloyd.bsky.social · 3mo ago

I wanted to share my new Spotlight in @cp-trendsgenetics.bsky.social that highlights a terrific paper linking gene body methylation with noise in gene expression: Silencing the noise with gene body methylation doi.org/10.1016/j.ti...

Two postdocs, one mainly computational and one mainly wet lab, will be joining us on a collaborative project between my lab and Radu Zabet lab exploring deregulation of enhancers in glioblastoma @blizardinstitute.bsky.social @qmul.bsky.social Check out the advert and apply!

Dr Radu Zabet@raduzabet.bsky.social · 4mo ago

My lab and @smarino0111.bsky.social lab are currently looking for 2 PDRAs on a 3-year @bartscharity.bsky.social funded project. The posts will be based in Blizard Institute within Queen Mary Faculty of Medicine and Dentistry. Check out the details and apply here: qmul-jobs.tal.net/vx/mobile-0/...

My lab and @smarino0111.bsky.social lab are currently looking for 2 PDRAs on a 3-year @bartscharity.bsky.social funded project. The posts will be based in Blizard Institute within Queen Mary Faculty of Medicine and Dentistry. Check out the details and apply here: qmul-jobs.tal.net/vx/mobile-0/...

The BHF PhD programme has 10 studentships now recruiting at the Universities of Cambridge, Edinburgh, Oxford & Imperial College! www.cam.ac.uk/jobs/bhf-4-y... Cambridge has 5 studentships available. Check us out here: www.phpc.cam.ac.uk/research/dep... Plz RT and feel free to get in touch!

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

Abstract submission for the Mol Hem Workshop is now open here ehaweb.org/connect-netw... Submit for your chance to present your latest unpublished work in a highly visible session that forms part of the EHA annual meeting program in Stockholm.

Excited to share our latest publication on interindividual variation of DNA methylation in human whole blood, spearheaded by the amazing Olivia Grant and co-led with @leo-schalkwyk.bsky.social and Meena Kumari. link.springer.com/article/10.1...

Systematic investigation of interindividual variation of DNA methylation in human whole blood - Genome Biology

Background Interindividual genetic variability is well characterised, but we still lack a complete catalogue of loci displaying variable and stable epigenetic patterns. Results Here, we report a catal...

link.springer.com

Join @berasymbionts.bsky.social , @tatsuyanobori.bsky.social and us for a postdoc on the remarkable developmental biology of symbiosis! Applications are due March 25th 🪲🦠 @johninnescentre.bsky.social @thesainsburylab.bsky.social

John Innes Centre@johninnescentre.bsky.social · 5mo ago

VACANCY - We’re searching for a Postdoctoral Researcher to join the newly appointed group of Dr @hassansalem.bsky.social, to explore the developmental biology of host-microbe symbiosis www.jic.ac.uk/vacancies/po... Deadline - 25 March 2026 Salary - £37,500 - £45,350 Contract - 3 years, full-time

New from @chemamd.bsky.social lab @qmulsbbs.bsky.social Collab with Elaine Seaver, @baxevanislab.bsky.social @neva-meyer.bsky.social @abhinavsur.bsky.social New chromosome-level assembly for Capitella teleta 🪱 academic.oup.com/gbe/advance-... #DevBio #WormWednesday @genomebiolevol.bsky.social

Transposable elements are increasingly studied in single-cell data, but how reliable are current locus-level quantification methods in short-read scRNA-seq data? If you work with single-cell RNA-seq or TEs, we hope this is a useful resource — feedback very welcome!

Veronica Finazzi@veronicafin.bsky.social · 5mo ago

Happy to share our new preprint! 📊 We benchmarked methods for locus-level transposable element quantification in short-read scRNA-seq, using both real datasets and simulations with read-level ground truth. Huge thanks to @catavallejos.bsky.social and @antonio-scialdone.bsky.social! #TEsky

A plant #histone H3.3-specific #amino acid safeguards the deposition of H3K36 #methylation for proper #development and #stress responses www.cell.com/developmenta... #PlantScience #SciComm @cp-devcell.bsky.social @epigeneticspod.bsky.social @epigenometech.bsky.social @histone3.bsky.social

A plant histone H3.3-specific amino acid safeguards the deposition of H3K36 methylation for proper development and stress responses

Plant histone variant H3.3 uniquely carries T31 rather than the S31 found in animals. Li et al. demonstrate that T31 prevents plant-specific ATXR5/6-mediated H3K27me1 deposition, which would otherwise...

cell.com

We are one of the potential host labs for a Lecturer position in Molecular Genetics & Genomics — please share, and get in touch for more info! 🧬📣

IBDM, Institut de Biologie du Développement de Marseille@ibdm.bsky.social · 6mo ago

🧬 The Department of Biology at @univ-amu.fr will soon recruit a lecturer in Molecular Genetics & Genomics (Eukaryotes). 🧪 Apply with an eligible team: Bertrand; Delacour; Kodjabachian; Libé-Philippot; Mann; Schaeffer; Thomas. Details: lnkd.in/eFS8qQpU

🚨3-year Postdoc Position @halloulab.bsky.social (Kennedy Institute, Oxford) - on Spatial Biology & Bioinformatics of Fibrosis🚨 An exciting project combining #SpatialTranscriptomics & #Mechanobiology👇: shorturl.at/LLS5r Deadline: 16 March - Please RT 📢! @kiroxford.bsky.social @ox.ac.uk

March 4th is world obesity day. Obesity is a chronic relapsing disease and is not a choice. #obesityisnotachoice

www.cell.com/cell/fulltex...

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

Giant DNA viruses encode a cap-binding complex homologous to eIF4F, the defining translation-initiation complex of eukaryotes. The viral cap-binding complex is required for viral protein synthesis and...

cell.com

Diving into evolutionary biology! What is the origin of the most abundant class of insect transcription factors, ZAD-ZnFs? We suggest that they evolved from ancestral insulator-binding proteins that control 3D genome topology. www.science.org/doi/10.1126/...

Decoding the molecular logic of rapidly evolving ZAD zinc finger proteins in Drosophila

Identification of ZAD-ZnF genes as key regulators of genome organization during Drosophila embryogenesis.

science.org

Domain-adaptation deep learning models do not outperform simple baseline models in single-cell anti-cancer drug sensitivity prediction #SingleCell 🧪🧬🖥️ https://www.biorxiv.org/content/10.64898/2026.02.24.707713v1

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab. @mrclmb.bsky.social Please get in touch if you have any questions. www.nature.com/naturecareer...

Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Cambridge, Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12854636

Research Group Leader Tenure Track Starting Salary £67,979 to £76,868 per annum MRC Laboratory of Molecular Biology, Cambridge, UK The MRC Laborato...

nature.com

Sjors Scheres@sjorsscheres.bsky.social · 6mo ago

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

'We show that histone butyrylation on H3K27 is detected in human colon samples. Furthermore, histone acetylation, butyrylation, and propionylation on H3K9 and H3K27 are responsive to levels of SCFAs in human colon cancer cell lines and are associated with active gene regulatory elements.' #preprint

Fascinating discovery by team @stanfordbiosci.bsky.social www.cell.com/cell/abstrac...

Nutrient competition predicts gut microbiome restructuring under drug perturbations

Systematic profiling of 707 drugs on their impact on stool-derived microbial communities shows that nutrient competition explains and predicts species shifts under drug treatment and that post-drug re...

cell.com

The function of nuclear speckles is revealed! This is an incredibly important paper with absolutely beautiful data! Wow! www.cell.com/cell/fulltex...

Nuclear speckles enable processing of RNA from GC-rich isochores

Nuclear speckles are key subnuclear structures that regulate gene expression in GC-rich regions. This work shows that the evolution and expansion of core speckle proteins were crucial for the increase...

cell.com

Karolinska Institute is hiring for 7 new positions! Individual job details below!👇 #ScienceJobs

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR www.nature.com/naturecareer...

Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14

Ancient co-option of LTR retrotransposons as yeast centromeres - Nature

Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

nature.com

Regulatory Features and Functional Specialization of Human Endogenous Retroviral LTRs: A Genome-Wide Annotation and Analysis via HERVarium https://www.biorxiv.org/content/10.64898/2026.02.17.706328v1