Vincent Graziano
@vinnieviruses.bsky.social
Postdoc’ing in Andrew Wang’s Lab Yale internal Medicine: Rheumatology | former UConn Health PhD candidate - Rathinam Lab | Former postgrad in the Wilen Lab at Yale | RNA is life
Once in a while, we get the privilege to enjoy works like this: www.science.org/doi/10.1126/...
Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase
Defense-associated reverse transcriptases (DRTs) are widespread bacterial anti-phage systems that use unconventional mechanisms of polynucleotide synthesis. We show that DRT3, which comprises two dist...
science.org
I'm glad to see this being covered - because, frankly, this is a death-blow to collaborative science - however, the assumption of good faith in any of these decisions by reporters is mind-boggling. This is happening for one reason - to assure top-down control of what gets funded and what does not.
Max Kozlov@maxkozlov.bsky.social · 5mo agoThe US NIH is stepping back from 'top-down' science. My latest analysis for @nature.com shows that funding calls have plummeted by 90%, funneling billions into broad, 'investigator-initiated' ideas, rather than targeted, agency-driven ones. A massive shift for the American biomedical enterprise.
Out today in Nature - our collaborative work with Ryan Flynn's lab, led by Dr. Peiyuan Chai with support from Dr. @sinakheiri.bsky.social and @shahjess.bsky.social from our group. Exciting findings showcasing how glycoRNAs can modulate angiogenesis!
Ryan Flynn@raflynn5.bsky.social · 6mo agoScience update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
Huge advance in glycoRNA biology. Congrats to @raflynn5.bsky.social and all of the wonderful authors! Can’t wait to see what you guys do next!
Ryan Flynn@raflynn5.bsky.social · 6mo agoScience update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
Thanks to Autoimmunity podcast @kevinbonham.bsky.social & @woodrufflab.bsky.social for discussing our glycoRNA paper w/ @raflynn5.bsky.social @vinnieviruses.bsky.social
@audiommunity.org · 10mo agoIn our latest episode, @woodrufflab.bsky.social and @kevinbonham.com talk about glycoRNAs, and the way they're shielded from the immune system in a new paper from the labs of @raflynn5.bsky.social and @vijayrathinam.bsky.social 🧪 audiommunity.org/episodes/epi...
In our latest episode, @woodrufflab.bsky.social and @kevinbonham.com talk about glycoRNAs, and the way they're shielded from the immune system in a new paper from the labs of @raflynn5.bsky.social and @vijayrathinam.bsky.social 🧪 audiommunity.org/episodes/epi...
Episode 47 - When you're a hammer
YouTube video by Audiommunity
youtube.com
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation: Molecular Cell www.cell.com/molecular-ce... @raflynn5.bsky.social @vinnieviruses.bsky.social
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
A new function of glycosylated RNAs has been discovered by Graziano et al. in which the glycosylation of RNA molecules shields acp³U RNA modification from triggering innate immune responses.
cell.com
Don’t trust the experts”? That’s not democracy, that’s recklessness. On a plane, I want a pilot. In a hospital, I want doctors and scientists who understand the evidence. Expertise isn’t religion or authoritarianism — it’s training, accountability, and data. Ignore it and we all pay the price.
Republicans Against Trumpism@rpsagainsttrump.bsky.social · 11mo agoRFK Jr: We need to stop trusting the experts... Trusting the experts is not a feature of science or democracy, it's a feature of religion and totalitarianism.
🚨New Paper in Cell 🧵🔎 Happy to share our work led by the @camilahcoelho.bsky.social, on mAbs against mpox. We were very excited (and lucky!) to contribute to this collab. effort. 🦠“Human monoclonal antibodies targeting A35 protect from death caused by mpox”🦠 doi.org/10.1016/j.cell.2025.08.004
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
Another piece of the #glycoRNA puzzle revealed by @raflynn5.bsky.social and @vijayrathinam.bsky.social!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity. www.nature.com/articles/s41...
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
nature.com
4/5 The Glycobiology Significant Achievement Award: Dr. Ryan Flynn @raflynn5.bsky.social, Harvard University, 👏👏🥂
@vijayrathinam.bsky.social @vinnieviruses.bsky.social @raflynn5.bsky.social discovers why RNA undergoes glycosylation: N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells @nature.com www.nature.com/articles/s41...
Incredible discovery ! The first known role for sugar coated RNAs : immune evasion ! @raflynn5.bsky.social does it angain with @vinnieviruses.bsky.social @vijayrathinam.bsky.social and colleagues !
Ryan Flynn@raflynn5.bsky.social · 12mo agoRNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
Check out this @nature.com paper from the brilliant scientist I get to call my husband!!!!
Vincent Graziano@vinnieviruses.bsky.social · 12mo agoHi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors www.nature.com/articles/s41...
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
Big congrats to Vinnie Graziano @vinnieviruses.bsky.social who led the project and huge thanks to our great collaborators: Jennifer Porat, Thomas Carell, Franck Barrat, Beiyan Zhou, Sivapriya Kailasan Vanaja, Michael Wilson, and Penghua Wang!! #innate_immunity #interferon #celldeath
Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors www.nature.com/articles/s41...
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
nature.com
Wow Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions ki.se/en/about-ki/...
Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
ki.se
The science being done in my lab right now is the best in my 20 years as a professor at UW. It's just incredible whiplash to flip between that the science funding situation here in the US, and to think about the societal abandonment of the brilliant young trainees who are pushing the work forward.
My next paper is going to be written like a Choose your own Adventure: To do a Western Blot from the pulldown, go to page 7 To CRISPR out the functional domains, go to page 46 To skip till the Acknowledgements, go to page 52
**US-CAN Doctoral Excellence Award @WesternU -$160,000 to 25 PhD students for up to 4 years. - Must've had offer rescinded/cancelled from US school. -Expedited admission process. -Feel free to reach out, if interested in a PhD in inorganic chem! www.forbes.com/sites/michae...
A Leading Canadian University Makes A Pitch For Top U.S. PhD Students
Western University, one of Canada’s leading public research universities, is launching an initiative aimed at luring away PhD students from premier U.S. institutions.
forbes.com
If you were too young in 2003 here is what Bush told the American people: 1) The Iraq War won’t cost a lot of money 3) We won’t need a lot of troops 4) We’ll bring peace and freedom to Iraq 5) We’ll find WMDs 6) We’ll be welcomed as liberators 7) It will be easy 8) It won’t take long All lies.
Can confirm: 60 Minutes will be worth watching tonight about #NIH.
Jeremy Berg@jeremymberg.bsky.social · last yr.TV watching recommendations The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration. 1/2
Pope Francis lifted the world as he led the Church with his profound moral voice. As he returns to God, may his call to humility and concern for the least among us continue to resound.
From a source at NIH: “Right now NIH’s ability to buy things is dead. Nearly all people with the power to make an order — purchasing people — have been removed. The NIH hospital can’t buy medicines, the labs can’t buy petri dishes. X-Ray machine breaks? Too bad. Everything is stopped”
“This will go down as one of the darkest days in modern scientific history” 🧪 www.nature.com/articles/d41...
‘One of the darkest days’: NIH purges agency leadership amid mass layoffs
In shock move, four institute directors at the US biomedical agency are removed from their posts.
nature.com
There is no other way to say this: Today is the day the CDC was essentially dissolved. What's left is a husk. People will die as a direct result. www.wired.com/story/cdc-gu...
The CDC Has Been Gutted
Thousands of CDC employees who worked on things like preventing HIV and lead poisoning have been told they were subject to a reduction in force. Experts say people will die.
wired.com
