Richard Eva Lab
@richardevalab.bsky.social
CNS regeneration lab, King's College London, Wolfson SPaRC. We use neuronal cell biology to study axon regeneration, identifying and testing new therapies for eye disease and spinal cord injury.
Far from a static structure, the ER actively shapes its environment. See how its motility allows it to physically shape the cellular environment in this microscopy footage from Dong Li (CAS) & Andy Moore (Janelia): youtu.be/DnOYwPLhq60 doi.org/10.1016/j.ce... #FluorescenceFriday #Microscopy
It does not happen often that a Current Biology review is turned into a YouTube video, but when it is done like this here by Anton Petrov, it is something that should happen more often!👁️👁️👁️ www.cell.com/current-biol... www.youtube.com/watch?v=6LP3...
We Actually Have a Third Eye (And It’s Not Metaphysical)
YouTube video by Anton Petrov
youtube.com
Our article on how GSK3b controls microtubule bundling in axons is live 🎉 Here's our #notthecover attempt www.pnas.org/doi/10.1073/...
This is amazing...
Dr. Keith R. Brunt@profbrunt.bsky.social · 7mo agoEpstein-Barr Virus #EBV was linked to #MultipleSclerosis - now a plausible cause has been found, misidentification by longterm memory T-cells that pick on the wrong protein, ANO2, instead of the EBV-antigen. Massive inflection towards the elimination of MS!!! 🧪🧠Cell www.cell.com/cell/fulltex...
Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation. Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com
Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism
Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy ...
nature.com
Our latest review with @doctorpaf.bsky.social! We discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1. -Challenges for SARM1 inhibition for neuroprotection -Roles in non-neuronal cells -SARM1 activation for selective peripheral neuroablation dlvr.it/TNnCBh
In this review @Andrea-Loreto.bsky.social and I discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1 - Challenges for SARM1 therapeutic inhibition - SARM1 in non-neuronal cells - SARM1 activation for selective peripheral neuroablation. www.cell.com/trends/pharm...
Targeting SARM1: from inhibition for neuroprotection to activation for neuroablation
Sterile alpha and TIR motif-containing protein 1 (SARM1),is a central enzyme that drives programmed axon degeneration and has gathered significant interest as a therapeutic target. Despite preclinical...
cell.com
I’m excited to share that my PhD work is out in @jcb.org! Big thanks to my amazing mentor @stephgupton.bsky.social and inspiring collaborator @coronin.bsky.social!!!!
Journal of Cell Biology@jcb.org · 10mo agoHo, @stephgupton.bsky.social et al. find that coronin 1A mediates neuronal growth cone & filopodial dynamics, & its interaction with E3 ubiquitin ligase TRIM67 is required for morphological responses to the guidance cue netrin-1 rupress.org/jcb/article/... #Neuroscience #Cytoskeleton #Development
Happy to announce our preprint going live on BioRxiv! Interested in what’s happening to your fibroblasts’ transcriptomic phenotype once it’s in culture? Look no further! www.biorxiv.org/content/10.1... @denklab.bsky.social #fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal
Single-cell RNA sequencing clarifies dermal fibroblast subset representation in vitro and reveals variable persistence of keloid disease-associated features
In vitro models of scarring and fibrosis are essential to improve our understanding of disease mechanisms and ultimately develop much-needed effective therapeutic strategies. This is particularly true...
biorxiv.org
The long and newly updated story of lithium and its potential role for helping to prevent Alzheimer's disease erictopol.substack.com/p/lithium-an...
A huge thank you to the Eva and Bradbury Lab members, @wolfsonsparc.bsky.social, and all the GRC CNS Injury and Repair attendees. So much fun, so much science and all top quality. A poster prize for Zahra to top it off! New ideas, collaborations, connections. As a great conference should be!
*New paper alert* - extracellular tau blocks synaptic plasticity in vivo via its microtubule-binding domain, which can be rescued by our Gen2 tau antibodies - all the product of a great collaboration with Michael Rowan and colleagues at @tcddublin.bsky.social link.springer.com/article/10.1...
Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region - Acta Neuropathologica
Immunotherapies targeting extracellular tau share the premise that interrupting cell-to-cell spread of tau pathology in Alzheimer’s disease (AD) will slow dementia pathogenesis. Whether these interven...
link.springer.com
What an interesting paper, such a huge amount of work! Great to see it cover the different CNS and PNS axon types. And thank you for the thread: enjoyed following the story, showing how many people were involved, how long it took, and how it all came together. A phenomenal community effort!
Mike Fainzilber@mfainzilber.bsky.social · last yr.A 🧵 to walk those interested through this paper...
Researchers in the Reh Lab have produced the clearest evidence yet that AAV-delivered genes can stimulate regeneration in the mammalian retina. @tomreh.bsky.social Marina Pavlou. #retina #regeneration @uwmedicine.bsky.social shorturl.at/qVUKz
Regenerating Retinal Neurons using AAV Vectors / ISCRM
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shorturl.at
Our paper is finally out! Neuronal autophagy controls excitability via ryanodine receptor-mediated regulation of calcium-activated potassium channel function. www.pnas.org/doi/abs/10.1...
Neuronal autophagy controls excitability via ryanodine receptor–mediated regulation of calcium-activated potassium channel function | PNAS
Glutamate-mediated neuronal hyperexcitation plays a causative role in eliciting seizures and promoting epileptogenesis. Recent data suggest that al...
pnas.org
NeuroCure.bsky.social@neurocure.bsky.social · last yr.🧠✨ When the brain’s “clean-up” system (autophagy) fails, #neurons become overactive-linked to epilepsy. Blocking the BKCa potassium channel calms them down. New hope for #brain disease treatments! Collaboration across #Berlin institutes & NC researchers highlights the teamwork. tinyurl.com/47z72apy
A fantastic place to work with brilliant colleagues in a vibrant part of London! Wolfson SPaRC is hiring for Lecturer and above-level roles. Come and be part of the exciting work happening here. Amazing people, meaningful impact, and a location that’s hard to beat.
Wolfson SPaRC@wolfsonsparc.bsky.social · last yr.The Wolfson SPaRC (Sensory, Pain and Regeneration Centre) is recruiting! Two posts available at Lecturer, Senior Lecturer or Reader position. Take a look! @kingsioppn.bsky.social #TranslationalResearch #SpinalCordandBrainRepair #HearingLoss #ChronicPain #Migraine www.kcl.ac.uk/jobs/111846-...
Excellent story from the Woolf lab! www.nature.com/articles/s41...
Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration - Nature Communications
Therapeutic interventions for motor axon regeneration following peripheral nerve injury are currently unavailable. Here authors show local administration of a non-muscle myosin II inhibitor at the inj...
nature.com
Significant functional improvements in walking speed/endurance for people with spinal cord injury with combined 4-aminopyridine and paired associative stimulation. A great study by Dr. Monica Perez and an All Star group. #SCIrehab 🧪 #phySKYatry academic.oup.com/brain/advanc...
Combinatorial approaches increasing neuronal activity accelerate recovery after spinal cord injury
Chen et al. report that patients with spinal cord injury who received treatment with a combination of Hebbian stimulation to strengthen corticospinal synap
academic.oup.com
Excited to share the latest work from our lab: www.biorxiv.org/content/10.1...
Biphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafish
Fibrosis and persistent inflammation are interconnected processes that inhibit axon regeneration in the mammalian central nervous system (CNS). In zebrafish, by contrast, fibroblast-derived extracellu...
biorxiv.org
Our CNS regeneration work has now been published in @PNAS. It was a huge undertaking in collaboration with @Twiss @Benowitz @WardLab_Emory @KristyWelshhans @Marktuszynski @jenniferDulin @ArthurEnglish @JohnHolule labs. Thank you all, and @MerkinPnnrCtr, for funding. www.pnas.org/doi/10.1073/...
Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration | PNAS
Depletion or inhibition of core stress granule proteins, G3BP1 in mammals and TIAR-2 in Caenorhabditis elegans, increases the growth of spontaneous...
pnas.org
An exciting paper demonstrating a complex integrin trafficking mechanism with potential implications for the machinery regulating axon growth and regeneration. Intriguing!
Alison Forrester@aforrester.bsky.social · last yr.I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday
Masalmeh, RHA, et al. FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation. bioRxiv posted 20 February 2025 doi:10.1101/2024.12.11.627900. www.biorxiv.org/content/10.1...
FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation
Glycolysis and the TCA cycle are reprogrammed in cancer cells to meet bioenergetic and biosynthetic demands, including by engagement with the extracellular matrix (ECM). We show that focal adhesion ki...
biorxiv.org
I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social www.nature.com/articles/s41...
Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain - Nature Methods
A first-in-class fluorescence lifetime-based FRET sensor for phosphatase and tensin homolog (PTEN) enables the dynamic monitoring of PTEN activity in cultured cells and in vivo with high spatiotempora...
nature.com
Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?! doi.org/10.1016/j.cu...
ICYMI our latest paper is now out officially in print (is there still such thing?). And since Dev Cell @cellpress.bsky.social did not select our submission for cover, I post it here. A really cool illustration from my son Zack. www.cell.com/developmenta...
Aged motor neurons display an impaired response to muscle BDNF, consistent with downregulation of TrkB at the neuromuscular junction.
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex...
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
cell.com
