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Turk Lab

@benturklab.bsky.social

We study protein kinases and their substrates in the Department of Pharmacology at Yale School of Medicine

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Yale Pharmacology@yalepharm.bsky.social · 2mo ago

Join us in welcoming our next 2025–2026 Pharmacology Seminar Series speaker, Dr. Anne-Claude Gingras of the Lunenfeld-Tanenbaum Institute. She will be presenting her work at 12 pm on Thursday, May 28th in the Brady Auditorium.

Flyer for the Yale Pharmacology Seminar Series 2025–2026. This flyer indicates that Anne-Claude Gingras, PhD will be presenting her work at 12:00 pm on Thursday, May 28, 2026 in the Brady Auditorium. Dr. Gingras is Director of the Lunenfeld-Tanenbaum Research Institute, Vice President of Research at Sinai Health, and Professor of Molecular Genetics at the University of Toronto. The title of her talk is "When Kinases Fuse: Uncovering the Regulatory Logic of Oncogenic Kinase Signaling."
Nilsson lab@nilssonlab.bsky.social · 5mo ago

Happy to see our work on defining a dependency map of short linear motifs out. We use base editing screens to install more than 80000 mutations into SLiMs in more than 4000 proteins to determine their contribution to cell fitness. www.nature.com/articles/s41...

A proteome-wide dependency map of protein interaction motifs - Nature Structural & Molecular Biology

Ambjørn and Meeusen et al. functionally characterize all reported and a comprehensive set of predicted short linear motifs (SLiMs) using base-editing screens, identifying 450 reported and 264 predicte...

nature.com

Sharpe Lab@sharpe-lab.bsky.social · 7mo ago

Pervanadate is more than just a phosphatase inhibitor! Read our paper just published in #sciencesignaling showing that pervanadate oxidises and activates SRC kinase too. Link: tinyurl.com/5ype7e2s Thanks for the 'focus' by: @nshahlab.bsky.social tinyurl.com/54fcjds3 @babrahaminst.bsky.social

Pervanadate-induced oxidation relieves autoinhibition of the protein tyrosine kinase SRC

A widely used tyrosine phosphatase inhibitor also oxidizes and activates the tyrosine kinase SRC.

science.org

Thomas Arnesen@natmachinery.bsky.social · 7mo ago

Intricate regulation of Src kinases via N-terminal modifications and specific degradation pathways. A novel degradation pathway involving the CUL4A-DDB1-DCAF10 E3 ligase found by Kremer et al. Tanja Bange lab @andrea-musacchio.bsky.social @ispt-proteinterm.bsky.social www.nature.com/articles/s41...

CUL4A-DDB1-DCAF10 is an N-recognin for N-terminally acetylated Src kinases - Nature Communications

Cells depend on early protein modifications for proper function. Here, the authors show that when Src-family signaling kinases lack their typical myristoylation, an alternative acetylated start is det...

nature.com

Paola Laurino@paolalaurino.bsky.social · 10mo ago

we just posted our new work on #SRC #kinase led by the superb Prashant Jain 🤩 Inspired by nature, we discover that the length of the catalytic loop and the autophosphorylation site can be engineered to fine-tune downstream pathway activation. 🙏🏻 @oistedu.bsky.social www.biorxiv.org/content/10.1...

Minimal Perturbation of Activation Loop Dynamics Rewires Kinase Signaling

Enzymes are central to life, with their catalytic activity often shaped by the dynamic conformations of regulatory loops. In hub enzymes such as tyrosine kinases, the activation loop critically contro...

biorxiv.org

Neel Shah@nshahlab.bsky.social · last yr.

Excited to see this paper out in its final form, and huge congrats to first author Ziyuan (Jason) Jiang just a week before his thesis defense. This work has become an invaluable resource in our lab for SHP2 projects, and we hope it resonates with the whole field. www.nature.com/articles/s41...

Deep mutational scanning of the multi-domain phosphatase SHP2 reveals mechanisms of regulation and pathogenicity - Nature Communications

Comprehensive characterization of mutational effects in the human phosphatase SHP2 reveals mechanisms of intra- and inter-domain regulation, shedding light on the mechanisms of pathogenicity for hundr...

nature.com

Neel Shah@nshahlab.bsky.social · 2y ago

Excited to share our latest preprint on deep mutational scanning of the phosphatase SHP2!! This is actually a revamped version of one we posted this summer, but with lots of new analyses and figures! www.biorxiv.org/content/10.1...

Domain architecture diagram and crystallographic conformations of SHP2, showing arrangement of 2 non-catalytic domains and a phosphatase domain.
Helena Klara Jambor@helenajambor.bsky.social · last yr.

I gave in! After students asking for it, I now made a simple figure design checklist. To help all scientists w/o graphic skills create clear, accessible, and truthful charts! -> Out in @nature Cell Biology: rdcu.be/erwl4 #DataVisualization #PhD #SciComm Thx for review @bethcimini.bsky.social + 2

A checklist for designing and improving the visualization of scientific data

Nature Cell Biology - Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data...

rdcu.be

Alex Holehouse@alexholehouse.bsky.social · last yr.

Now published! Big congrats to first author @gginell.bsky.social We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions. www.science.org/doi/10.1126/...

Sequence-based prediction of intermolecular interactions driven by disordered regions

Intrinsically disordered regions (IDRs) in proteins play essential roles in cellular function. A growing body of work has shown that IDRs often interact with partners in a manner that does not depend ...

science.org

Alex Holehouse@alexholehouse.bsky.social · 2y ago

Excited to share new work from Garrett Ginell et al where we present an approach for predicting intermolecular interaction driven by disordered regions. We focus on how chemical complementarity can contribute to and even dictate intermolecular interactions www.biorxiv.org/content/10.1...

Evangelia Petsalaki@epetsalaki.bsky.social · last yr.

We present SELPHI 2.0 a machine learning model integrating >40 sequence, omics and structural features to predict kinase-substrate interactions between 420 kinases and 240K phosphosites and improve interpretation of global phosphoproteomics data www.sciencedirect.com/science/arti...

Data-driven extraction of human kinase-substrate relationships from omics datasets

Phosphorylation forms an important part of the signalling system that cells use for decision making and regulation of processes such as cell division …

sciencedirect.com

Itai Yanai@itaiyanai.bsky.social · last yr.

In today's episode of the Night Science Podcast we talk with Martin Schwartz from Yale about the importance of stupidity in science: while learning science makes you feel smart, true scientific discovery often involves feeling stupid, because it means venturing into the unknown.

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The Night Science Podcast@nightsciencepod.bsky.social · last yr.

New Night Science Podcast episode! Martin Schwartz from Yale talks with us about the importance of stupidity in scientific research, how the ego can obstruct creativity, and how resilience, self-discovery, and "passionate indifference" – are key in science. podcasts.apple.com/us/podcast/n...

Beth Popp Berman@epopppp.bsky.social · last yr.

Another way to put this: Musk and his twerps have exposed us to pandemics, broken science, stolen all your data, endangered the U.S. payments system, threatened air traffic control, and cut off HIV medication to 20m people in order to save ::checks notes:: 2/10th of a percent of the federal budget.

Bloomberg News@bloomberg.com · last yr.

DOGE says it has saved $55 billion in federal spending so far, but its website only accounts for $16.6 billion of that