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Baptiste Darracq

@baptistedarracq.bsky.social

Postdoc in the PGB lab at Institut Pasteur | integrons, bacterial immunity

6 Posts122 Follower223 Folgt
Xavier Charpentier@labxc.bsky.social · 4w ago

#microsky New preprint from the lab! Widespread immune systems protect bacteria against conjugative plasmids www.biorxiv.org/content/10.6... Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab. 🧵⬇️

Widespread immune systems protect bacteria against conjugative plasmids

Conjugative plasmids are a class of mobile genetic elements capable of efficient transfer between bacterial cells. Although they can introduce beneficial traits such as antibiotic resistance to recipi...

biorxiv.org

Institut Pasteur | 130 years of biomedical research@pasteur.fr · 2mo ago

Congrats @baptistedarracq.bsky.social & @marialopopolo.bsky.social two Pasteurians awarded the Academy of Sciences' "Major Advances in Biology" Prize for groundbreaking Science publications on bacterial defense & ancient leprosy. pubmed.ncbi.nlm.nih.gov/40339013/ pubmed.ncbi.nlm.nih.gov/40440428/

Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems - PubMed

Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...

pubmed.ncbi.nlm.nih.gov

BejaLabTechnion@bejalab.bsky.social · 2mo ago

Viral theft of light: A cyanophage protein dismantles cyanobacterial photosynthesis to accelerate infection www.cell.com/cell-host-mi...

Viral theft of light: A cyanophage protein dismantles cyanobacterial photosynthesis to accelerate infection

Auxiliary metabolic genes, acquired by cyanobacterial viruses (cyanophages) from their hosts, are thought to manipulate host metabolism during infection. A recent study by Nadel et al. performed in vi...

cell.com

Marie-Eve VAL@val-meve.bsky.social · 3mo ago

This one means a lot. Our paper, “Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome,” is out! doi.org/10.1038/s414...

Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome - Nature Communications

Bacterial genomes often include extrachromosomal replicons, ranging from small plasmids to chromosome-scale replicons. Here, Czarnecki et al. analyse more than 40,000 complete bacterial genomes and sh...

doi.org

Kenneth Loi@kenjmloi.bsky.social · 3mo ago

Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.

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Mart Krupovic@mkrupovic.bsky.social · 4mo ago

"The selfish ribosome" paper is now published in @plosbiology.org . Have a look! Many thanks to the editors and reviewers! doi.org/10.1371/jour...

The selfish ribosome

In this Essay, the evolution of life is construed as a ribosomal takeover, whereby the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensured the propagatio...

journals.plos.org

Mart Krupovic@mkrupovic.bsky.social · 5mo ago

With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268

Eduardo Rocha@epcrocha.bsky.social · 4mo ago

Our ms on re-sampling 4 years apart vibrio phage in natural environments is now out with some improvements. First, clearer evidence of cryptic population dynamics between phage and vibrio, presumably because of genetic diversity. www.nature.com/articles/s41...

Complex temporal dynamics of phage-bacteria populations in an animal-associated marine system - Nature Communications

It remains unclear how viral genomes remain relatively stable over time, given the rapid co-evolution seen within hosts. Here, authors explore complex marine phage-bacteria dynamics using over 1000 ph...

nature.com

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Pedro Dorado-Morales@doradomoralesp.bsky.social · 6mo ago

A short research stay in 2019 (back in the pre-COVID era) at José R. Penadés lab turned into the third chapter of my PhD and today it finally sees the light.

Targeted elimination of Staphylococcus aureus mastitis infections with synthetic phage-based CRISPR-Cas delivery systems - npj Biofilms and Microbiomes

npj Biofilms and Microbiomes - Targeted elimination of Staphylococcus aureus mastitis infections with synthetic phage-based CRISPR-Cas delivery systems

nature.com

Cascales Lab@cascaleslab.bsky.social · 8mo ago

Happy to share the last work of @jmartinkus.bsky.social, led by @dukasju.bsky.social Immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @currentbiology.bsky.social Kudos !! www.cell.com/current-biol...

Poly-immunity arrays associated with Rhs toxins confer wide protection against competitors

Martinkus et al. show that Photorhabdus and Xenorhabdus species encode arrays of immunity genes whose protein products neutralize toxins secreted by competitors. These arrays, often linked to Xer pass...

cell.com

Kevin Debatisse@kdebatisse.bsky.social · 9mo ago

Our new paper is out in @narjournal.bsky.social We show that natural transformation enables bacteria to shuffle integron cassettes, boosting their phenotypic diversity. academic.oup.com/nar/article/... 1/5

Bacterial natural transformation drives cassette shuffling and simplifies recombination in chromosomal integrons

Abstract. Integrons act as biobanks of gene cassettes conferring functions crucial for bacterial defense, including protection against phages and antibioti

academic.oup.com

Paul Rainey@paulbrainey.bsky.social · 9mo ago

@prczhaoyansong.bsky.social’s deep dive into the dark matter of compost communities is now out 🎉 Genomic islands hijack jumbo phages—whose capsids enable transfer of large tracts of DNA—shedding new light on the scale & scope of phage-mediated gene flow 😎 www.pnas.org/doi/10.1073/...

Jumbo phage–mediated transduction of genomic islands | PNAS

Bacteria acquire new genes by horizontal gene transfer, typically mediated by mobile genetic elements (MGEs). While plasmids, bacteriophages, and c...

pnas.org

Sternberg Lab@sternberglab.bsky.social · 10mo ago

1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. www.biorxiv.org/content/10.1...

Antiviral reverse transcriptases reveal the evolutionary origin of telomerase

Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...

biorxiv.org

Frédérique Le Roux@fredoleroux.bsky.social · 10mo ago

Phages evolve fast, or do they? In oysters, some stay identical for years. With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements. Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...

Ecological constraints foster both extreme viral-host lineage stability and mobile element diversity in a marine community

Phages are typically viewed as very rapidly evolving biological entities. Little is known, however, about whether and how phages can establish long-term genetic stability. We addressed this eco-evolut...

biorxiv.org

Zeynep Baharoglu@zeynepbaharoglu.bsky.social · 11mo ago

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters

Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.

science.org

Céline Loot@celineloot.bsky.social · last yr.

At least 10% of the V. cholerae integron cassettes have novel antiphage activities (see below). Considering that there are 25,000 distinct cassettes of unknown function, integrons constitute an extraordinary and almost inexhaustible reservoir of antiphage functions!

Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems

Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...

science.org

Eduardo Rocha@epcrocha.bsky.social · last yr.

Our paper on how integrons are biobanks of novel minimal defense systems is now out www.science.org/doi/10.1126/... Two main conclusions on this excellent work led by @eloilittner.bsky.social @baptistedarracq.bsky.social 1/n

Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems

Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...

science.org

Eloi Littner@eloilittner.bsky.social · last yr.

Habemus paper! Our story on integron-encoded anti-phage defenses is now out in @science.org! 16 new systems, small versions of known ones, and a lot more in this highly-collaborative study. Many thanks to everyone involved, especially my supervisor @epcrocha.bsky.social bsky.app/profile/bapt...

Jose A Escudero@jaescudero.bsky.social · last yr.

Our paper is published back2back with one from @amazeld.bsky.social and @epcrocha.bsky.social labs where @baptistedarracq.bsky.social, @eloilittner.bsky.social and co. show that Sedentary Chromosomal Integrons are biobanks of phage defense systems. www.science.org/doi/10.1126/...

Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems

Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...

science.org

Baptiste Darracq@baptistedarracq.bsky.social · last yr.

White smoke, we have a new pope and also 16 new anti-phages systems in sedentary integrons (SCIs) ! In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones. www.science.org/doi/10.1126/...

Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems

Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...

science.org

Stephan Gruber@gruberlab.bsky.social · last yr.

Glad to share the work of @yli18smc.bsky.social and co on Lamassu, a bacterial defense system related to Rad50/Mre11 (RM). While RM carefully trims DNA ends for repair, Lamassu chops up the host chromosome. Our study reveals how it is regulated to minimize damage, activating only during infection.

Alt : Structure of the apo Lamassu protein complex. Schematic model of the active LmuA tetramer nuclease (top right). Lamassu icon (top left).